个人简介

Ph.D., Devlopmental Genetics University of Essex, UK B.S., Biology University of California, Irvine 1987-Present Professor Department of Biology California State University, San Bernardino 2004-2006 Director, MS Program in Biotechnology and Bioinformatics California State University, Channel Islands 1981-1987 Research Scientist City of Hope Medical Center

研究领域

Genetic and developmental analysis of tumorous head, a third chromosome homeotic mutant of Drosophila melanogaster. Development of an EMS screen for the third chromosome which produced a tumorous head allele. Development of an in vitro assay to identify teratogens utilizing Drosophila embryonic cells. Neuronal and muscle development during Drosophila embryogenesis. Use of amniotic fluid and chorionic villi cells to assess environmentally induced heat shock proteins in the fetus. Induction of heat shock proteins and their role in abnormal development. Assessing effect of Electro-magnetic fields (EMF) on Drosophila embryonic development. Investigating the possible connection between telomerase activity and programmed cell death after exposure to EMF. Utilization of P-mediated transformed Drosophila to investigate promoter control and expression of heat shock proteins. Identification of possible relationship between altered programmed cell death pattern in embryos, heat shock protein induction after teratogen-exposure.

I am by education and training a developmental geneticist. I have been very much interested in identifying how early development is governed by the interplay of genes and the environment. My organism of choice has always been Drosophila melanogaster. Currently I am employing a Drosophila model of Alzheimer’s Disease to investigate the interactions between aging and Alzheimer’s and how dietary interventions might ameliorate the disease phenotype. Studies are also underway to identify the role that mating plays in delaying the aging process in Drosophila melanogaster. Another current area of research is identifying and establishing ovarian and malpighian tubule derived stem cells so that they can be utilized to identify trophic factors and cell cell interactions that drive determination and differentiation.

近期论文

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Bournias-Vardiabasis, N., Pifer, S 2003. Gender Verification: Determination of the Status Quo. IDISEEP Proceedings. Bournias-Vardiabasis, N., Nguyen, P., and Phillips, J. L 2002. Exposure of Drosophila Embryonic Cells to a 60Hz Sinusoidal Magnetic Field: Effect on Teratogenesis and Heat Shock Protein 70 Expression. Alternatives in Animal Testing. Vol 3. Bournias-Vardiabasis, N., Huh, K. W., Hopkins, K., and Chun, T-W. 1998. Induction of low molecular weight heat shock proteins on Drosophila and human embryonic lineage cells after teratogens exposure. In Salem and Katz's "Advances in Animal Alternatives for Safety and Efficacy Testing" . Koundakjian, E. J., Bournias-Vardiabasis, N., Haggren, W., Adey, W. R., and Phillips, J. L. 1996. Exposure of Drosophila melanogaster embryonic cell cultures to 60 Hz sinusoidal magnetic fields: Expression of heat shock proteins 23 and 27. In Vitro Toxicology 3:281-289. Bournias-Vardiabasis, N., Nguyen, P., and Phillips, J. L. 1995. Exposure of Drosophila cells to a 60 Hz sinusoidal magnetic field: Effect on teratogenesis and heat shock protein 70 expressions. Alternative Methods in Toxicology 11:153:159. Nguyen, P., Bournias-Vardiabasis, N., Haggren, W., Adey, W. R. and Phillips, J. L.. 1995. Exposure of Drosophila melanogaster Embryonic Cell Cultures of 60 Hz Sinusoidal Magnetic Fields: Assessment of Potential Teratogenic Effects. Teratology 51:273-277. Bournias-Vardiabasis, N. 1994. Teratogen detection assay using fruit fly embryos. Humane Innovations and Alternatives. 8:630-634. Bournias-Vardiabasis, N., Hopkins, K., Teigen, J., and Chun, T W., 1993. Induction of low molecular weight heat shock proteins in Drosophila: contributors to normal development or to teratogenesis? Europ. Dros Res. Conf. 13:113. Bournias-Vardiabasis, N., Nugyen, P., Haggren, W., Adey, W. R., and Phillips, J. L. 1993. Teratogenic response of Drosophila embryonic cells to 60 Hz magnetic field exposure with and without chemical teratogens. Europ. Dros. Res. Conf. 13. Bournias-Vardiabasis, N., Hopkins, K., and Wang, B. 1993. Evaluating teratogen exposure utilizing cDNA. Alternative Methods in Toxicology 9:226. Bournias-Vardiabasis, N. Flores, J. and Buzin, C. 1990. Differential expression of heat shock proteins in Drosophila embryonic cells following metal ion exposure. Experimental Cell Research 189:177-182. Bournias-Vardiabasis, N. 1990. Drosophila melanogaster embryo cultures: An in vitro teratogen assay. ATLA 18:291-300. Bournias-Vardiabasis, N., Ananthan-Nair, J., and Voellmy, R. 1990. Detection of teratogens by utilization of -galactosidase reporter gene technology. Teratology 41:539. Bournias-Vardiabasis, N. 1990. Drosophila melanogaster embryo cultures: an in vitro teratogen assay. ATLA, 18:291-300. Bournias-Vardiabasis, N., C. Buzin, and J. Flores. Differential expression of heat shock proteins in Drosophila embryonic cells following metal ion exposure. Experimental Cell Research, 189:177-182. Bournias-Vardiabasis, N. 1987. Altered differentiation and induction of heat shock proteins in Drosophila embryonic cells associated with teratogen treatment. Banbury Reports 26: 3-16. Salvaterra, P. M., N. Bournias-Vardiabasis, T. Nair, G. Hou and C. Lieu. 1987. In vitro neuronal differentiation of Drosophila embryo cells. J. Neurosci. 7: 10-22. Bournias-Vardiabasis, N. and J. C. Flores. 1986. Response of Drosophila melanogaster embryonic cells to tumor promoters: Carcinogens as teratogens. Toxicology and Applied Pharmacology, 85: 196-206. Bournias-Vardiabasis, N. and C. Buzin. 1986. Developmental effects of chemicals and the heat shock responses in Drosophila cells. Teratogenesis, Carcinogenesis and Mutagenesis 6: 523-536.