McReynolds, Katherine - California State University, Sacramento

个人简介

B.S. Biochemistry Cal Poly SLO, 1994 M.A. Chemistry University of Arizona 1996 Ph.D. Chemistry University of Arizona 1999 Postdoc Univ. California, Davis 1999-2001

研究领域

My research is focused on the development of novel branched sugar-based polymers, known as glycodendrimers, as potential therapeutic agents. Much of the current work in the lab is devoted to the synthesis and chemical characterization of the dendrimers and glycodendrimers. This process involves using several chemical techniques such as TLC, chromatography (flash, size exclusion, ion exchange, HPLC), NMR and interpretation of mass spectral data. In addition to these techniques, additional work is currently underway to investigate the biological properties of the glycodendrimers using ELISA (enzyme-linked immunosorbent assay). Once biologically active compounds have been identified, further testing of the compounds will be conducted and will include cell culture toxicity assays and live pathogen assays.

近期论文

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^Clayton, R.McReynolds, K.D.Synthesis of Sialic Acid-PAMAM Glycodendrimers without the Use of Protecting Groups.Manuscript in preparation. ^Watterson, M.McReynolds, K.D.Synthesis of Novel Glucosamine-Based Glycodendrimers. Manuscript in preparation. *Patane, J.; *Trapani, V.; *Villavert, J.McReynolds, K.D.Preparative Production of Colominic Acid Oligomers via a Facile Microwave Hydrolysis.Carb. Res.2009,344, 820-824. McReynolds, K.D.; Gervay-Hague, J. Chemotherapeutic Interventions Targeting HIV Interactions with Host-Associated Carbohydrates.Chem. Rev.,2007,107(5), 1533-1552. McReynolds, K.D.Glycobiology: How to Sugar-Coat an Undergraduate Advanced Biochemistry Lab.Biochem. Mol. Biol. Educ. 2006,34(5), 369-377. Conboy, J.C.McReynolds, K.D.; Gervay-Hague, J.; Saavedra, S.S. Quantitative Measurements of Recombinant HIV Surface Glycoprotein Gp120 Binding to Several Glycosphingolipids Expressed in Planar Supported Lipid Bilayers.J. Am. Chem. Soc.,2002,124(6), 968-977. McReynolds, K.D.; Bhat, A.; Conboy, J.C.; Saavedra, S.S.; Gervay-Hague, J. Non-natural Glycosphingolipids and Structurally Simpler Analogs Bind HIV-1 Recombinant Gp120.Bioorg. Med. Chem.2002,10(3), 625-637. K.D. McReynolds; How Sweet It Is: Perspectives on the Importance of Carbohydrates in Biochemistry, Medicine and the Mainstream, Award address for receipt of the CSUS President’s Award for Research and Creative Activity, October 27, 2010. K.D. McReynolds; Studies Directed Towards the Synthesis of Novel Glycodendrimers as Potential Therapeutic Agents, Invited talk at the Rocky Mountain Regional American Chemical Society Meeting, October 2006. K.D. McReynolds; Glycodendrimers as Novel Anti-Viral Agents, Invited seminar at The University of the Pacific, Stockton, CA, November 2005. K.D. McReynolds; (no title submitted).Invited speaker/participant at the NSF Workshop on Physical Organic Chemistry, Bodega Bay, CA, August 2005. K.D. McReynolds; The Study of Glycobiology in an Undergraduate Advanced Biochemistry Laboratory.Presented at the 229th American Chemical Society National Meeting, CHED 258, San Diego, CA, March 2005. K.D. McReynolds; Incorporation of Carbohydrates into an Advanced Biochemistry Laboratory.Presented at the 39th Annual American Chemical Society Western Regional Meeting, Sacramento, CA, October 27-30th 2004. S. Lindgren, Ballard, R., M. McCarthy-Hintz, L. Roberts, N. Ewing, D. Bell,K. McReynoldsDevelopment of a Molecular Biology Interdisciplinary Group at CSU Sacramento. Presented at the 15th Annual CSU Biotechnology Symposium, Pomona, CA, January 2003.