研究领域

Biochemistry

Biosynthesis of local steroid hormones and their functions keyword : steroids, endocrine, paracrine, cytochrome P450 2000.05. Functional Analysis for Cytochrome b5 and related heme prot keyword : Cytochrome b5, Outer mitochondrimal membrane 2002.04. Degradation Mechanism of Mitochondrial Proteins. keyword : proteolysis, heme synthesis, degrdation of mitochondrial proteins 2000.04.

近期论文

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Tadashi Ogishima, Andrea Vecchiola, Carlos F Lagos, Cristóbal A Fuentes, Fidel Allende, Carmen Campino, Carolina Valdivia, Alejandra Tapia-Castillo, Kuniaki Mukai, Gareth Owen, Sandra Solari, Cristian A Carvajal, Carlos E Fardella,Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro,Reproductive Biology and Endocrinology,Vol.76,2013, 11:76,2013.08. Tadashi Ogishima, Higuchi, A, Inoue, H, Kawakita, T, Tsubota, K,Selenium Compound Protects Corneal Epithelium against Oxidative Stress ,PLoS ONE,Vol.7,No.9,2012.09. Tadashi Ogishima, Anders Höög, A, Mukai, K, Lu, M., Thorén, M, Hamberger, B,Immunohistochemistry improves histopathologic diagnosis in primary aldosteronism,J Clin Pathol.,66, 351-354,2013.01. Nishimoto,K., Nakagawa, K., Li, D., Kosaka, T., Oya, M., Mikami, S., Shibata, H., Itoh, H., Mitani, F., Yamazaki, T., Ogishima , T., Suematsu, M., & Mukai, M ,Adrenocortical Zonation in Humans under Normal and Pathologic Conditions.,J. Clin. Endocrinol. Metab,Vol.95,pp.2296 - 2305,2010.08. Tadashi Ogishima,VARIEGATED ZONATION IN HUMAN ADRENAL CORTEX,2010.05. Ogishima, T., Mitani, F., & Suematsu, M. ,Cytochrome P-45017alpha in beta-cells of Rat Pancreas and its Local Steroidogenesis. . ,J. Steroid Biochem. Mol. Biol. ,110, in press ,2008.07. Yoshino, K., Munakata, H., Kuge, O., Ito, A., & Ogishima, T. ,Heme-regulated Degradation of delta-Aminolevulinate Synthase 1 in Rat Liver Mitochondria. ,J. Biochem,142, 453-467,2007.09. Nishino, T., Kitano, K., Kojima, K., Ogishima, T., Ito, A., and Kitada, S. ,Spatial orientation of mitochondrial processing peptidase and a preproteinrevealed by fluorescencer esonance energy transfer.,J. Biochem.,2007.06. Taketoh, J., Mutoh, J., Takeda, T., Ogishima, T., Takeda, S., Ishii, Y., Ishida, T., & Yamada, H. ,Suppression of fetal testicular cytochrome P45017 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanis involving an initial effect on gonadotropin synthesis in the pituitary.,Life Sci.,80, 1259-1267,2007.02. Kitada, S., Uchiyama, T., Funatsu, T., Kitada, Y., Ogishima, T., & Ito, A.,A Protein from a Parasitic Microorganism Rickettsiae can Cleave the Signal Sequences of Proteins Targeting Mitochondria.,J. Bacteriol.,189, 844-850,2007.02. Fumiko Mitani, Tadashi Ogishima, Kuniaki Mukai and Makoto Suematsu,Ascorbate Stimulates Monooxygenase-dependent Steroidogenesis in Adrenal Zona Glomerulosa.,Biochem. Biophys. Res. Commun.,Vol.338,No.1,338, Issue 1,2005.12. Ogishima, T., Kinoshita, J., Mitani, F., Suematsu, M., & Ito, A.,Identification of Outer Mitochondrial Membrane Cytochrome b5 as a Modulator for Androgen Synthesis in Leydig Cells.,Journal of Biological Chemistry,Vol.278,No.23,278, 21202-21211, 2003,2003.07. Kojima, K., Yamazaki, E., Kitada, S., Ogishima, T., & Ito, A.,Recognition of Mitochondrial Protein Precursor Lacking Arginine at Position -2 by Mitochondrial Processing Peptidase.,Journal of Biochemistry,Vol.130,No.4,130, 497-502, 2001,2001.03. Kojima, K., Kitada, S., Ogishima, T., & Ito, A.:,A Proposed Common Structure of Substrates Bound to Mitochondrial Processing Peptidase.,Journal of Biological Chemistry,Vol.276,No.3,276, 2115-2121, 2001,2001.07. Nagao,Y., Kitada, S., Kojima, K., Toh, H., Kuhara, S., Ogishima, T., & Ito, A.,Possible Function of Glycine-rich Region in Mitochondrial Processing Peptidase a-subunit.,Journal of Biological Chemistry,275, 34552-34556, 2000,2000.10. Moriwaki, K., Ogishima,T., & Ito, A.,Analysis of Recognition Elements for Mitochondrial Processing Peptidase Using Artificial Amino Acids.,Journal of Biochemistry,Vol.126,No.5,276, 874-878,1999,1999.05. Shimokata, K., Kitada, S., Ogishima, T., & Ito, A.,Role of a-Subunit of Mitochondrial Processing Peptidase in Substrate Recognition.,Journal of Biological Chemistry,Vol.273,No.39,273, 25158-25163, 1998,1998.08. Kojima, K., Kitada, S., Shimokata, K., Ogishima, T., & Ito, A.,Cooperative Formation of a Substrate-Binding Pocket by a-and b-subunits of Mitochondrial Processing Peptidase.,英語,Vol.273,No.49,273, 32542-32546, 1998,1998.08. Kitada, S., Shimokata, K., Ogishima, T., & Ito, A.,Glutamate Residues Required for Substrate Binding and Cleavage Activity in Mitochondrial Processing Peptidase.,Journal of Biological Chemistry,Vol.273,No.49,273, 32547-32553, 1998,1998.10. Ogishima, T., Niidome, T., Shimokata, K., Kitada, S., & Ito, A.:,Analysis of Elements in the Substrate Required for Processing by Mitochondrial Processing Peptidase.,J. Biol. Chem.,Vol.270,No.51,270, 30322-30326,1995.09.