Melikyan, Gagik - California State University, Northridge - Department of Chemistry and Biochemistry

个人简介

Ph.D., Institute of Elementorganic Compounds, Moscow, 1977 D.Sc., Institute of Organic Chemistry, Yerevan, 1990 Alexander von Humboldt Fellow, University of Erlangen-Nurnberg, 1990-1992 Adjunct Professor of Chemistry, University of Oklahoma, 1993-1995

研究领域

Organic / Organometallic / Medicinal Chemistry Radical and ionic reactions of transition metal-complexed unsaturated compounds; new synthetic methodologies in organic and organometallic chemistries; computational, spectroscopic, and structural analyses of transition metal-stabilized carbocations; novel therapeutic agents for breast cancer treatment; enzymatic chemistry; aromatase metabolism; non-steroidal hormones; food chemistry; antioxidants; supplements; cosmetics; environmental chemistry.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

"Acquiring a Prognostic Power in Co2(CO)6-Mediated, Cobaltocene-Induced Radical Dimerizations of Propargyl Triflates" Melikyan, G.G.; Davis, R.; Anker, B.; Meron, D.; Duncan, K. Organometallics (2016) 35, 4060-4070. "Acquiring and exploiting persistency of propargyl radicals: Novel paradigms" Melikyan, G.G.; Davis, R.; Cappuccino, S. Organometallics (2016) 35, 2854-2867. "Radical Reactions of 1,4-Alkadiynes: Metal Coordination as an Effective Tool for Controlling the Regio- and Stereoselectivity of the C-C Bond Formation" Melikyan, G.G.; Anker, B. Organometallics (2015) 34, 4194-4197. "Propargyl Radical Chemistry: Renaissance Instigated by Metal Coordination" Melikyan, G.G. Accounts of Chemical Research (2015) 48, 1065-1079. "Assembling Contiguous Quaternary Carbons Atoms: Regio- and Stereoselective Rearrangements in Cobalt-Directed Radical Reactions of 1,4-Enynes" Melikyan, G. G.; Hughes, R.; Rivas, B.; Duncan, K.; Sahakyan, N. Organometallics (2015) 34, 242-253. "Radical Reactions of the Cobalt-Complexed Propargyl Acetals: Inter- and Intramolecular Variants" Melikyan, G. G.; Voorhees, E.; Sepanian, R. Organometallics (2014) 33, 69-83. "Impact of Reducing Agent, Temperature, and Substrate Topology on Diastereoselectivity of the Intermolecular Coupling Reactions, or How “Free” Are Cobalt-Complexed Propargyl Radicals?" Melikyan, G. G.; Carlson, L.; Sahakyan, N.; Floruti, A.; Garrison, M. Dalton Transactions (2013) 42, 14801–14812. "Cobaltocene-Induced Low-Temperature Radical Coupling Reactions in a Cobalt-Alkyne Series." Melikyan, G. G.; Rivas, B.; Harutyunyan, S.; Carlson, L.; Sepanian R. Organometallics (2012) 31, 1653-1663. "1,3-Steric Induction in Intermolecular Radical Reactions Mediated by a Co2(CO)6-Metal Core." Melikyan, G. G.; Spencer, R.; Rowe, A. Organometallics (2010) 29, 3556-3562. "Inter- and Intramolecular Isocarbon Couplings of Cobalt-Complexed Propargyl Radicals: Challenging the Consensus." Melikyan, G. G.; Spencer, R. Tetrahedron (2010) 66, 5321-5328. "Carbon Tether Rigidity as a Stereochemical Tool Directing Intramolecular Radical Cyclizations." Melikyan, G. G.; Vorhees, E.; Wild, C.; Spencer, R.; Molnar, J. Tetrahedron Letters (2010) 51, 2287-2290. "Stereoselective Synthesis of meso-1,5-Cyclodecadiynes." Melikyan, G. G.; Spencer, R.; Abedi, E. J. Org. Chem. (2009) 74, 8541-8546. "Cobalt-Complexed Propargyl Cations: Generation under Neutral Conditions and Spontaneous, High-Temperature Conversion to Propargyl Radicals. " Melikyan, G. G.; Sepanian, R.; Spencer, R.; Rowe, A.; Toure, P.Organometallics (2009) 28, 5541-5549. "High-Temperature Reaction of a Co2(CO)6-Complexed Propargyl Cation. " Melikyan, G. G.; Mikailian, B.; Sepanian, R.; Toure, P. J. Organomet. Chem. (2009) 694, 785-794. "Intramolecular Radical Cyclizations of Co2(CO)6-Complexed Propargyl Radicals: Synthesis of d,l- and meso-1,5-Cyclodecadiynes." Melikyan, G. G.; Wild, C.; Toure, P. Organometallics (2008) 27, 1569-1581. "Cross-Coupling of Cobalt-Complexed Propargyl Radicals: Metal Core- and alpha- and gamma-Aryl-Induced Chemo- and Diastereoselectivity." Melikyan, G. G.; Floruti, A.; Devletyan, L.; Toure, P.; Dean, N.; Carlson, L. Organometallics (2007) 26(13), 3173-3182. "Tetrahydrofuran-Mediated Stereoselective Radical C-C Bond Formation in Dicobalthexacarbonyl-Propargyl Complexes." Melikyan, G. G.; Villena, F.; Floruti, A.; Sepanian, S.; Sarkissian, H.; Rowe, A.; Toure, P.; Mehta, D.; Christian, N.; Myer, S.; Miller, D.; Scanlon, S.; Porazik, M.; Gruselle, M. Organometallics (2006) 25, 4680-4690. Invited review: Gagik Melikyan. Ligand-Based Organometallic Radical Chemistry: An Emerging Interdisciplinary Field in: Frontiers in Organometallic Chemistry. Ed. M. A. Cato, Nova Science Publishers, 2006, Ch. 7, 155-190. "Spontaneous Generation and Stereoselective Coupling of Co2(CO)6-Complexed Propargyl Radicals," Melikyan, G. G.; Villena, F.; Sepanian, S.; Pulido, M.; Sarkissian, H.; Floruti, A. Organic Letters (2003) 5, 3395-3397. "Tetrahydrofuran - Mediated Radical Processes: Stereoselective Synthesis of dl-Hexestrol," Melikyan, G. G.; Sepanian, S.; Riahi, B.; Villena, F.; Jerome, J.; Ahrens, B.; McClain, R.; Matchett, J.; Scanlon, S.; Abrenica, E.; Paulsen, K.; Hardcastle, K. I. J. Organomet. Chem. (2003) 683(2), 324-330. "Thymidine 3',5'-Diphosphoric Acid Derived Cations and Radicals: Ab Initio Study," Toure, P.; Villena, F. and Melikyan, G. G. Organic Letters (2002) 4, 3989-3992. "Interaction of Propargyl Cation with Tetrahydrofuran: Thermodynamics, Kinetics, and Biological Relevance," Toure, P.; Myer, S. and Melikyan, G. G. J. Phys. Chem. A (2001) 105, 4579-4584. "Hydroalumination-Brominolysis of Vinylacetylenic Alcohols: A Novel Entry to E - and Z - Bromodienols, and Bromoallenols," Gharibian, H.; Palikyan, G.; Badanyan, Sh.H.; Paulsen, K. and Melikyan, G. G. Helv. Chim. Acta. (2000) 83, 3291-3294. "Manganese(II)/(III) Glycolates: Preparation, X-Ray Crystallographic Study, and Application in Radical Cycloaddition Reactions," Melikyan, G. G.; Amiryan, F.; Visi, M.; Hardcastle, K. I. and Bales, B. L. Inorg. Chim. Acta (2000) 308, 45-50. "Reduction of Metal-Stabilized Alpha-CF3-Carbenium Ion Complexes under Mild Conditions: Synthesis, Structures, and Reactivity.," Gruselle, M., Malezieux, B., Andres, R., Amouri, H., Vaissermann, J. and Melikyan, G. G., Eur. J. Org. Chem. (2000), 359-368.