Fischhaber, Paula - California State University, Northridge - Department of Chemistry and Biochemistry

个人简介

B.A. Biochemistry, University of Colorado, Boulder Ph.D., University of Washington, Seattle University of Texas Southwestern Medical Center at Dallas

研究领域

Dr. Fischhaber's group is investigating the protein biochemistry of DNA repair in S. cerevisiae (baker’s yeast). In human beings, failure to repair covalent modifications to DNA (DNA damage) by the biologic repair pathways results in genetic mutations and cancer, particularly skin cancer. DNA damage is ubiquitous in living cells and much of it is unavoidable, so DNA repair pathways are crucial for survival. We use a variety of in vitro biochemical techniques as well as fluorescence microscopy to establish the temporal and spatial relationships among key proteins participating in DNA repair. The ultimate goal is to understand precisely how cells direct themselves toward the most appropriate DNA repair pathway to avoid burdensome levels of mutations that could otherwise give rise to cancer.

近期论文

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“Saw1 localizes to repair sites but is not required for recruitment of Rad10 to repair intermediates bearing short non-homologous 3' flaps during single-strand annealing in S. cerevisiae”, Mardirosian, M., Nalbandyan, L., Miller, A. D., Phan, C., Kelson, E. P. and Fischhaber, P. L. Mol. Cell. Biochem. (2016) 412(1), 131-139. "Rad7 E3 ubiquitin ligase attenuates polyubiquitylation of Rpn10 and Dsk2 following DNA damage in Saccharomyces cerevisiae". Benoun, J.M., Cortez, D.L., Valencia, A., Moore, D.M., Granda, A., Kelson, E.P. and Fischhaber, P.L. Adv. Biol. Chem. (2015), 5, 239-254. “FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress”, Yang, Y., Liu, Z., Wang, F., Temviriyanukul, P., Ma, X., Tu, Y., Lv, L., Lin, Y.F., Huang, M., Zhang, T., Pei, H., Chen, B.P,. Jansen, J.G., de Wind, N., Fischhaber, P.L., Friedberg E.C., Tang, T.S., Guo, C. NAR (2015), 43(17), 8325-39. “Toward Therapeutic Targets for SCA3: Insight into the Role of Machado–Joseph Disease Protein Ataxin-3 in Misfolded Proteins Clearance” Li, X., Liu, H., Fischhaber, P. L., Tang, T.S. Progress in Neurobiology (2015), 132, 34-58. “Epigenetic Modifications as Novel Therapeutic Targets for Huntington’s Disease”, Wang, F., Fischhaber, P.L., Guo, C. and Tang, T. Epigenomics (2014), 6(3), 287-297. "SAW1 is Required for SDSA Double-Strand Break Repair in S. cerevisiae". Diamante, G., Phan, C., Celis, A.S., Krueger, J., Kelson, E.P. and Fischhaber, P.L. Biochem. Biophys. Res. Commun. (2014), 445, 602-607. "Rad51 ATP binding but not hydrolysis is required to recruit Rad10 in synthesis-dependent strand annealing sites in S. cerevisiae". Karlin, J. and Fischhaber, P.L. Adv. Biol. Chem. (2013), 3, 295-303. "Rad10-YFP focus induction in response to UV depends on RAD14 in yeast". Mardiros, A., Benoun, J.M., Haughton, R., Baxter, K., Kelson, E.P. and Fischhaber, P.L. Acta Histochem. (2011), 113, 409-415. "Rad10 exhibits lesion-dependent genetic requirements for recruitment to DNA double-strand breaks in Saccharomyces cerevisiae". Moore, D. M., Karlin, J., González-Barrera, S., Mardiros, A., Lisby, M., Doughty, A., Gilley, J., Rothstein, R., Friedberg, E.C. and Fischhaber, P.L. Nucleic Acids Res. (2009) 37(19), 6429-6438. "DNA polymerases for translesion DNA synthesis: enzyme purification and mouse models for studying their function". Fischhaber, P. L., McDaniel, L. D. and Friedberg, E. C., Methods Enzymol. (2006) 408, pp. 355-378. "How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?" Fischhaber, P. L. and Friedberg, E. C. DNA Repair (Amst). (2005) 4(2), 279-83. "DNA repair in yeast". Friedberg, E. C., Fischhaber, P. L. Encyclopedia of Molecular Cell Biology and Molecular Medicine 2nd Ed. Meyers, R. A., Editor (2004) 3, 427-447. "Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis". Guo, C., Fischhaber, P. L., Luk-Paszyc, M., Masuda, Y., Zhou, J., Kamiya, K., Kisker, C. and Friedberg, E. C. EMBO Journal (2003) 22(24), 6621-6630. "TB or not TB: How Mycobacterium tuberculosis may evade drug treatment". Friedberg, E. C. and Fischhaber, P. L. Cell (2003) 113, 139-140. "DNA replication fidelity". Friedberg, E. C. and Fischhaber, P. L. Nature Encyclopedia of the Human Genome (2003), 2, 167-171. "Human polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides". Fischhaber, P. L., Gerlach, V. L., Feaver, W. J., Hatahet, Z., Wallace, S. S. and Friedberg, E. C. J. Biol. Chem. (2002), 277(40), 37604-37611. "Error-prone DNA polymerases: novel structures and the benefits of infidelity". Friedberg, E. C., Fischhaber, P. L. and Kisker, C. L. Cell (2001) 107, 9-12. "Purification and characterization of Pol kappa, a DNA polymerase encoded by the human DINB1 gene". Gerlach, V. L., Feaver, W. J., Fischhaber, P. L. and Friedberg, E. C. J. Biol. Chem. (2001) 276(1), 92-98.