研究领域

lipid biochemistry, cell biology, yeast genetics

Metabolism and physiological function of membrane sphingolipids keyword : sphingolipid, metabolism, membrane 2011.08～2011.08.

近期论文

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Morimoto Y, Tani M,Synthesis of mannosylinositol phosphorylceramides is involved in maintenance of cell integrity of yeast Saccharomyces cerevisiae,Mol Microbiol,Vol.in press,2014.12. Toume M, Tani M,Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast Saccharomyces cerevisiae.,FEMS Microbiol Lett.,2014.07. Uemura S, Shishido F, Tani M, Mochizuki T, Abe F, Inokuchi J,Loss of hydroxyl groups from the ceramide moiety can modify the lateral diffusion of membrane proteins in Saccharomyces cerevisiae.,J Lipd Res,Vol.55,2014.05. Motohiro Tani, Osamu Kuge,Involvement of Sac1 phosphoinositide phosphatase in metabolism of phosphatidylserine in the yeast Saccharomyces cerevisiae. ,Yeast,2014.02. Tani Motohiro, Osamu Kuge,Involvement of complex sphingolipids and phosphatidylserine in endosomal trafficking in yeast Saccharomyces cerevisiae.,Mol Microbiol.,Vol.86,No.5,2012.10. Nakase M, Tani M, and Takegawa K. ,Expression of budding yeast IPT1 produces mannosyldiinositolphosphorylceramide in fission yeast and inhibits cell growth. ,Microbiology,2012.02. Nakagawa T, Tani M, Sueyoshi N, and Ito M,The mucin box and signal/anchor sequence of rat neutral ceramidase recruit bacterial sphingomyelinase to the plasma membrane.,Biosci Biotechnol Biochem.,Vol.75,No.5,2011.05. Kuroda T, Tani M, Moriguchi A, Tokunaga S, Higuchi T, Kitada S, and Kuge O. ,FMP30 is required for the maintenance of a normal cardiolipin level and mitochondrial morphology in the absence of mitochondrial phosphatidylethanolamine synthesis.,Mol. Microbiol.,Vol.80,No.1,pp.248-265,2011.02. Tani M, and Kuge O,Requirement of a specific group of sphingolipid-metabolizing enzyme for growth of yeast Saccharomyces cerevisiae under impaired metabolism of glycerophospholipids.,Mol. Microbiol.,Vol.78,No.2,pp.395-413,2010.08. Tani M, and Kuge O,Defect of synthesis of very long-chain fatty acids confers resistance to growth inhibition by inositol phosphorylceramide synthase repression in yeast Saccharomyces cerevisiae.,J. Biochem.,Vol.148,No.5,pp.565-571,2010.08. Nakase M, Tani M, Morita T, Kitamoto-K H, Kashiwazaki J, Nakamura T, Hosomi A, Tanaka N, and Takegawa K.,Mannosylinositol phosphorylceramide is a major sphingolipid component and is required for proper localization of plasma membrane proteins in Schizosaccharomyces pombe.,J. Cell Sci.,Vol.123,pp.1578-1587,2010.04. Inoue T, Okino N, Kakuta Y, Hijikata A, Okano H, M. Goda H, Tani M, Sueyoshi N, Kambayashi K, Matsumura H, Kai Y, and Ito M.,Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase.,J. Biol. Chem.,Vol.284,pp.9566-9577,2009.04. Tani M, and Kuge O,Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail, which is involved in its localization in plasma membranes. ,Biochem Biophys Res Commun.,Vol.381,No.3,pp.328-332,2009.02. Hayashi Y, Okino N, Kakuta Y, Shikanai T, Tani M, Narimatsu H, and Ito M. ,Klotho-related protein is a novel cytosolic neutral β–glycosylceramidase. ,J. Biol. Chem.,Vol.282,pp.30889-30900,2007.10. Ito K, Anada Y, Tani M, Ikeda M, Sano T, Kihara A, and Igarashi Y.,Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes. ,Biochem Biophys Res Commun.,Vol.357,pp.212-217,2007.05. Tani M, and Hannun YA.,Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues: Role of palmitoylation in subcellular localization. ,J. Biol. Chem.,Vol.282,No.13,pp.10047-10056,2007.03. Tani M, and Hannun YA.,Analysis of membrane topology of neutral sphingomyelinase 2.,FEBS lett.,Vol.581,pp.1323-1328,2007.04. Tani M, Kihara A, and Igarashi Y.,Rescue of cell growth by sphingosine with disruption of lipid microdomain formation of Saccharomyces cerevisiae deficient in sphingolipid biosynthesis.,Biochem. J.,Vol.394,No.1,pp.237-242,2006.02. Tani M, Sano T, Ito M, and Igarashi Y.,Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. ,J. Lipid Res.,Vol.46,No.11,pp.2458-2467,2005.08. Tani M, Okino N, Sueyoshi N, and Ito M.,Conserved amino acid residues in the COOH-terminal tail are indispensable for the correct folding and localization, and enzyme activity of neutral ceramidase. ,J. Biol. Chem.,Vol.279,No.28,2004.05.