研究领域

Biochemistry

The Study on nociceptin receptor antagonist keyword : nociceptin, antagonist, agonist 2010.04. Studies on the mechanism in gene expression of nuclear receptors and the chemical risk assessments keyword : nuclear receptor, bisphenol A 2005.04.

近期论文

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Ayami Matsushima, Hirokazu Nishimura, Shogo Inamine, Yasuyuki Shimohigashi,Identification of affinity binding site of Cys(Npys)-elongated RYYRIK peptide antagonist by means of Cys→Ala mutated ORL1 nociceptin receptors.,Peptide Science 2012,pp.115-118,2013.03. Ayami Matsushima, Kerrianne Ryan, Yasuyuki Shimohigashi, Ian A. Meinertzhagen,An endocrine disruptor, bisphenol A, affects development in the protochordate Ciona intestinalis,Environ. Pollut.,Vol.173,2013.02. Liu X, Matsushima A, Nakamura M, Costa T, Nose T, Shimohigashi Y,Fine spatial assembly for construction of the phenol-binding pocket to capture bisphenol A in the human nuclear receptor estrogen-related receptor γ.,J. Biochem. ,Vol.151,No.4,pp.403-415,2012.04. Matsushima, A., Nishimura, H., Inamine, S., Uemura, S., Shimohigashi, Y.,Capturing of the free cysteine residue in the ligand-binding site by affinity labeling of the ORL1 nociceptin receptor.,Bioorg. Med. Chem.,Vol.19,pp.7597–7602,2011.09. Liu, X., Matsushima, A., Okada, H., and Shimohigashi, Y.,Distinction of the binding modes for human nuclear receptor ERRγ between bisphenol A and 4-hydroxytamoxifen,J. Biochem,Vol.148,pp.247–254,2010.05. Matsushima, A., Liu, X., Okada, H., Shimohigashi, M., and Shimohigashi, Y,Bisphenol AF is a Full Agonist for the Estrogen Receptor ERα, but a Highly Specific Antagonist for ERβ.,Environ. Health Perspect.,2010.04. Liu, X., Matsushima, A., Okada, H., and Shimohigashi, Y.,Functional role of the C-terminal Helix 12 peptide in the receptor activation mechanism of estrogen-related receptor γ (ERRγ).,Peptide Science 2009,435–436,2010.03. Sato, K., Horiuchi, Y., Matsushima, A., and shimohigashi, Y.,The preparation and purification of prion protein N-terminal domain with fluctuations in the number of octapeptide repeat,Peptide Science 2009,433–434 ,2010.03. Li, J., Isozaki, K., Matsushima, A., Nose, T., Costa, T., and Shimoohigashi, Y.,Structure-function analysis of nociceptin receptor ORL1 by the site-directed mutagenesis,Peptide Science 2009,219–220,2010.03. Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.,Placenta expressing the greatest quantity of bisphenol A receptor ERRγ among the human reproductive tissues: predominant expression of type-1 ERRγ isoform,J. Biochem., ,146, 113-122,2009.10. Matsushima, A., Okada, H., Liu, X., Tokunaga, T., Teramoto, T., Kakuta, Y., Shimohigashi, Y.,Induced-fit type ligand binding guided by free-rotatory Leu residue present in the 7th α-helix peptide in the estrogen-related receptor γ (ERRγ),Peptide Science 2008,521-522,2009.03. Yokotani, S., Nose, T., Horiuchi, Y., Matsushima, A., and Shimohigashi, Y.,Radar chart deviation analysis of prion protein amino acid composition defines characteristic structural abnormalities of the N-terminal octapeptide tandem repeat.,Protein Peptide Sci.,15, 949-955 (2008),2008.08. Matsushima. A., Teramoto, T., Okada, H., Liu, X., Tokunaga, T., Kakuta, Y., and Shimohigashi, Y.,ERRγ tethers strongly bisphenol A and 4-α-cumylphenol in an induced-fit manner., Biochem. Biophys. Res. Commun.,373, 408-413 (2008),2008.12. Hattori, E., Yokotani, S., Horiuchi, Y., Matsushima, A., and Shimohigashi, Y.,The Effect of Amino Acid Substitution on Oligomerization of Octapeptide Repeat Structure in Prion Protein. ,Peptide Science 2007,239-242 (2008),2008.01. Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M., and Shimohigashi, Y.,Structural Requirement of Housefly FMRFamide Peptides in Its Receptor Activation.,Peptide Science 2007,313-314 (2008),2008.01. Takeda, Y., Koga, K., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.,The Output Mechanism of Circadian Pacemaker Neuropeptide PDF in the Regulation of Bimodal Locomotor Distribution,Peptide Science 2007,65-68 (2008),2008.01. Li, J. Isozaki, K., Matsushima, A., Nose, T., Costa, T., and Shimohigashi, Y.,Optimization of the N-Terminal Group of Ac-RYYRIK-NH2 as ORL1 Receptor Antagonist,Peptide Science 2007,257-260 (2008),2008.01. Li, J. Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T., and Shimohigashi, Y.,Design Synthesis of Highly Potent Antagonist of ORL1 Nociceptin Receptor.,Bioorg. Med. Chem.,16, 2635-2664 (2008),2008.01. Okada, H., Tokunaga, T., Lui, X., Takayanagi, S., Matsushima, A., and Shimohigashi, Y.,Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptor γ (ERRγ).,Environ. Health Perspect.,116, 32-38 (2008),2008.01. Liu, X., Matsushima, A., Okada, H., Tokunaga, T., Isozaki, K., and Shimohigashi, Y.,Receptor binding characteristics of endocrine disruptor bisphenol A: Chief and corroborative hydrogen bonds of bisphenol A phenol-hydroxyl group with Arg316 and Glu275 residues in the human nuclear receptor of estrogen-related receptor γ ,FEBS J.,274, 6340-6351 (2007),2007.10.