研究领域

Structure-Function Biochemistry

Receptor Sciences: Receptor chemistry of novel compounds that bind to the intracellular organella membrane receptors keyword : Receptor; Nuclear receptor; Endocrine disruptors; Drug side effects 2013.01. Receptor Sciences: Molecular mechanisms of nuclear receptor activation keyword : Receptor; Nuclear receptor; Bisphenol A; Constitutive activity; Endocrine disruptors; Low-dose effects 2000.09. Molecular Mechanisms of Functional Conformation Changes in Proteins keyword : membrane proteins; prion protein; metal ions; sensing of conformation changes 2003.04.

近期论文

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M. Shimohigashi, K. Kaibe, E. Nishi, T. Sawada, Yasuyuki Shimohigashi,An in vivo multi-generation propagation assay for endocrine disrupting chemicals in the fruit fly Drosophila melanogaster: Reproductive functions disrupted by 4-nonylphenol,Fukuoka University Science Report,Vol.43,No.2,pp.257-263,2013.10. Ayami Matsushima, R. Kerrianne, Yasuyuki Shimohigashi, I.A. Meinertzhagen,An endocrine disruptor, bisphenol A, affects development in the protochordate Ciona intestinalis: Hatching rates and swimming behavior alter in a dose-dependent manner,Environmental Pollution,Vol.173,pp.257-263,2013.01. Yasuyuki Shimohigashi, LIU XIAOHUI, Ayami Matsushima, Masayuki Nakamura, Takeru Nose,Fine spatial assembly for construction of the phenol-binding pocket to capture bisphenol A in the human nuclear receptor ERRγ,Journal of Biochemistry,Vol.151,No.4,pp.403-415,2012.03. A. Matsushima, H. Nishimura, S. Inamine, S. Uemura, and Y. Shimohigashi,Capturing of the free cysteine residue in the lgand binding site by affinity labeling of the ORL1 nociceptin receptor,Bioorganic & Medicinal Chemistry,Vol.19,pp.7597–7602,2011.06. M. Sumiyoshi, S. Sato, Y. Takeda, K. Sumida, K. Koga, T. Itoh, H. Nakagawa, Y. Shimohigashi, and M. Shimohigashi,A Circadian Neuropeptide PDF in the Honeybee, Apis mellifera: cDNA Cloning and Expression of mRNA,Zoological Science,Vol.228,No.12,pp.897-909,2011.06. Matsushima, A., Liu, X., Okada, H., Shimohigashi, M., and Shimohigashi, Y.,Bisphenol AF is a Full Agonist for the Estrogen Receptor ERα, but a Highly Specific Antagonist for ERβ.,Environ. Health Perspect.,118, 1267-1272 ,2010.09. Liu, X., Matsushima, A., Okada, H., and Shimohigashi, Y.,Distinction of the binding modes for human nuclear receptor ERRγ between bisphenol A and 4-hydroxytamoxifen.,J. Biochem.,148, 247-254,2010.07. D. Asai, T. Tokunaga, K. Kondo, T. Kawaguchi, S. Takayanagi, T. Shinmyozu, M. Nakai, Y. Yakabe, and Y. Shimohigashi.,Direct measure of fluorescence intensity for efficient receptor-binding assay: Conjugates of ethinylcarboxyestradiol and 5(and 6)-carboxyfluorescein via α,ω-diaminoalkanes as a tracer for estrogen receptor.,Journal of Biochemistry,143, 781–792,2008.10. A. Matsushima, T. Teramoto, H. Okada, X. Liu, T. Tokunaga, Y. Kakuta, Y. Shimohigashi.,ERRγ tethers strongly bisphenol A and 4-α-cumylphenol in an induced-fit manner.,Biochemical and Biophysical Research Communications,373, 408–413,2008.08. K. Okada, K. Isozaki, J. Li , A. Matsushima, T. Nose, T. Costa, and Y. Shimohigashi,Synergistic effect of basic residues at positions 14–15 of nociceptin on binding affinity and receptor activation,Bioorgnic Medicinal Chemistry,16, 9261–9267,2008.07. S. Yokotani, T. Nose, Y. Horiuchi, A. Matsushima, and Y. Shimohigashi,Radar chart deviation analysis of prion protein amino acid composition defines characteristic structural abnormalities of the N-terminal octapeptide tandem repeat.,Protein and Peptide Letters ,15, 949-955,2008.05. Nose T., Shimohigashi, Y.,A docking modelling rationally predicts strong binding of bisphenol A to estrogen-related receptor gamma,Protein and Peptide Letters ,15, 3, 290-296,2008.03. Matsushima, A., Shimohigashi, Y.,A strategy to explore the target receptor of endocrine disruptors: Estrogen-related receptor γ (ERRγ) as a genuine acceptor of bisphenol A,Alternatives to Animal Testing and Experimentation Journal,14, special issue, 495-497,2008.02. Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T., and Shimohigashi, Y,Design Synthesis of Highly Potent Antagonist of ORL1 Nociceptin Receptor,Bioorganic and Medicinal Chemistry ,16, 2635-2664,2008.01. Okada, H., Tokunaga, T., Lui, X., Takayanagi, S., Matsushima, A., and Shimohigashi, Y,Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptor γ (ERRγ),Environmental Health Perspectives ,116, 32-38,2008.01. Liu, X., Matsushima, A., Okada, H., Tokunaga, T., Isozaki, K., and Shimohigashi, Y.,Receptor binding characteristics of endocrine disruptor bisphenol A: Chief and corroborative hydrogen bonds of bisphenol A phenol-hydroxyl group with Arg316 and Glu275 residues in the human nuclear receptor of estrogen-related receptor γ (ERRγ),FEBS Journal ,274, 6340-6351,2007.09. Matsushima, A., Kakuta, Y., Teramoto, T., Koshiba, T., Liu, X., Okada, H., Tokunaga, T., Kawabata, S., Kimura, M., and Shimohigashi, Y.,Structural Evidence for Endocrine Disruptor Bisphenol A Binding to Human Nuclear Receptor ERR-gamma,Journal of Biochemistry,142, 517-524,2007.07. Matsushima, A., Takano, K., Yoshida, T., Takeda, Y., Yokotani, S., Shimohigashi, Y., and Shimohigashi, M.,Double-labeled in situ Hybridization Reveals the Lack of Co-localization of mRNAs for the Circadian Neuropeptide PDF and FMRFamide in Brains of the Flies Musca domestica and Drosophila melanogaster,Journal of Biochemistry,141, 867-877,2007.05. Honda, T., Matsushima A., Sumida K., Chuman Y., Sakaguchi K., Onoue H., Meinertzhagen I.A., Shimohigashi Y., and Shimohigashi, M.,Structural isoforms of the circadian neuropeptide PDF expressed in the optic lobes of the cricket Gryllus bimaculatus: Immunocytochemical evidence from specific monoclonal antibodies,Journal of Comparative Neurology,499, 404-421,2006.11. Takayanagi, S., Tokunaga, T., Liu, X., Okada, H., Matsushima, A., and Shimohigashi, Y.,Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor γ (ERRγ) with high cinstitutive activity,Toxicology Letters,195, 95-105,2006.10.