个人简介

2007–present Associate Professor of Chemistry, Carnegie Mellon University 2001–2006 Assistant Professor of Chemistry, Carnegie Mellon University 1999–2001 Postdoctoral Fellow, The Scripps Research Institute 1998–1999 Postdoctoral Fellow, UC Berkeley 1994–1998 Ph.D. in Chemistry, Georgia Institute of Technology 1990–1994 B.S. in Chemical Engineering, Georgia Institute of Technology

研究领域

Bioorganic & Chemical Biology/Materials & Nanoscience/Sensors/Probes & Imaging

Our research program for the past seven years has been focused on the design and development of molecular tools and reagents to regulate gene expression and probe protein localization and dynamics in human somatic and embryonic stem (ES) cells. We are particularly interested in dissecting the genetic blueprint of human ESC and addressing fundamental questions pertaining to the cellular origins of cancer. More recently, we have expanded our research program into other areas including protein design, tissue engineering and molecular self-assembly—taking advantage of the strength of the department, which is interdisciplinary research, combined with our ability to synthesize molecules that integrate all three features of the natural biopolymers: nucleic acids, proteins, and carbohydrates.

近期论文

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Srinivas Rapireddy, Linda Nhon, Robert E. Meehan, Jonathan Franks, Donna Beer Stolz, Dat Tran, Michael E. Selsted, Danith H. Ly RTD-1 mimic containing γPNA scaffold exhibits broad-spectrum antibacterial activities. J. Am. Chem. Soc. 2012, 134, 4041 Alon Singer, Srinivas Rapireddy, Danith H. Ly, Amit Meller Electronic barcoding of a viral genet at the single-molecule level. Nano Lett. 2012, 12, 1722 Emil Wierzbinski, Arnie de Leon, Xing Lin, Alexander Balaeff, Kathryn L. Davis, Srinivas Rapireddy, Ravindra Venkatramani, Shahar Keinan, Danith H. Ly, Marcela Madrid, David N. Beratan, Catalina Achim, David H. Waldeck Effect of backbone flexibility on charge transfer rates in peptide nucleic acid duplexes Raman Bahal, Bichismita Sahu, Srinivas Rapireddy, Chong-Min Lee, and Danith H. Ly Sequence-Unrestricted, WatsonˆCrick Recognition of Double Helical B-DNA by (R)-MiniPEG-gammaPNAs. Chembiochem, 2012, 13, 56 ˆ 60. Bichismita Sahu, Iulia Sacui, Srinivas Rapireddy, Kimberly J. Zanotti, Raman Bahal, Bruce A. Armitage, and Danith H. Ly "Synthesis and Characterization of Conformationally Preorganized, (R)-Diethylene Glycol-Containing γ-Peptide Nucleic Acids with Superior Hybridization Properties and Water Solubility" J. Org. Chem. (ASAP articles) Srinivas Rapireddy, Raman Bahal, and Danith H. Ly, "Strand Invasion of Mixed-Sequence, Double-Helical B-DNA by γ-Peptide Nucleic Acids Containing G-Clamp Nucleobases under Physiological Conditions" Biochemistry 2011, 50, 3913–3918 Joanne I. Yeh, Boris Shivachev, Srinivas Rapireddy, Matthew J. Crawford, Roberto R. Gil, Shoucheng Du, Marcela Madrid, and Danith H. Ly "Crystal Structure of Chiral γPNA with Complementary DNA Strand: Insights into the Stability and Specificity of Recognition and Conformational Preorganization" J. Am. Chem. Soc., 2010, 132, 10717–10727. Lusvarghi, S., Murphy, C,T., Roy, S., Tanious, F,A., Sacui, I., Wilson, W,D., Ly, D. H. Armitage . B,A. “Loop and Backbone Modifications of Peptide Nucleic Acid Improve G-Quadruplex Binding Selectivity” J. Am. Chem. Soc., 2009, 131 (51), pp 18415–18424 He, G., Rapireddy, S., Bahal, R., Sahu, B., and Ly, D. H. “Strand Invasion of Extended, Mixed-Sequence B-DNA by γPNAs” J. Am. Chem. Soc. 2009, 131, 12088–12090. Sahu, B., Chenna, V., Lathrop, K.L., Thomas, S.M., Zon, G., Livak, K, J., Ly, D. H. “Synthesis of Conformationally Preorganized and Cell-Permeable Guanidine-Based γ-Peptide Nucleic Acids (γGPNAs)” J. Org. Chem., 2009, 74, 1509–1516. Wu, Z., Lanni, E., Chen, W., Bier, M,E., Ly, D. H. Jin, R. “High Yield, Large Scale Synthesis of Thiolate-Protected Ag7 Clusters” J. Am. Chem. Soc., 2009, 131, 16672–16674. Chenna, V., Rapireddy, S., Sahu, B., Ausin, C., Pedroso, E., Ly, D. H. “A Simple Cytosine to G-Clamp Nucleobase Substitution Enables Chiral -PNAs to Invade Mixed-Sequence Double-Helical B-form DNA” ChemBioChem., 2008, 9, 2388–2391. Rapireddy, S., He, G., Roy, S., Armitage . B,A. Ly, D. H. “Strand Invasion of Mixed-Sequence B- DNA by Acridine-Linked, γ-Peptide Nucleic Acid (γ-PNA)” J. Am. Chem. Soc., 2007,129, 15596–15600. Zhou, P., Dragulescu-Andrasi, A., Bhattacharya, B., Hyldig-Nielsen, J. J., Ly, D. H. “Synthesis of cell-permeable peptide nucleic acid monomers and oligomers, and characterization of their hybridization and uptake properties”. Bioorg. Med. Chem. Lett. 2006, 16, 4931–4935. Dragulescu-Andrasi, A., Rapireddy, S., Frezza, B. M., Gayathri, C., Gil, R. R., Ly, D. H. “A simple γ-backbone modification preorganizes peptide nucleic acid into a helical structure.” J. Am. Chem. Soc. 2006, 128, 10258–10267. Dragulescu-Andrasi, A., Rapireddy, S., He, G., Bhattacharya, B., Hyldig-Nielsen, J. J., Zon, G., Ly, D. H. “Cell-permeable peptide nucleic acid designed to bind to the 5’-untranslated region of E-cadherin transcript induces potent and sequence-specific antisense effects”. J. Am. Chem. Soc. 2006, 128, 16104–16112. Dragulescu-Andrasi, A., Zhou, P., He, G., Ly, D. H. “Cell-Permeable GPNA Containing Appropriate Backbone Stereochemistry and Spacing Binds Sequence-Specifically to RNA” Chem. Comm. 2005, 244–246. Lagerholm, C. B., Wang, M., Ernst, L. A., Ly, D. H. Bruchez, M. P., Waggoner, A. S. “Multicolor Coding of Cells with Cationic Peptide Coated Quantum Dots” Nano Lett. 2004, 4, 2019–2022. Zhou, P., Wang, M., Du, L., Fisher, G., Waggoner, A., Ly, D. H. “Novel Binding and Efficient Cellular Uptake of Guanidine-Based Peptide Nucleic Acid (GPNA)” J. Am. Chem. Soc. 2003, 125, 6878–6879. Simbulan-Rosenthal, C.M., Ly, D.H., Rosenthal, D.S., Konopka, G., Luo, R-B., Wang, Z-Q., Schultz, P.G., Smulson, M.E. “Misregulation of Gene Expression in Primary Fibroblasts Lacking Poly(ADP-ribose) Polymerase” Proc. Nat. Acad. Sci. 2000, 97, 11274–11279.