个人简介

2008–present Professor, Carnegie Mellon University 1999–2008 Associate Professor, Carnegie Mellon University 1994–1999 Assistant Professor, Carnegie Mellon University 1993–1994 Assistant Research Professor, University of Minnesota 1988 Ph.D., University of Illinois

研究领域

Bioinorganic/Biophysical

Metalloproteins are essential for the basic processes of life, including DNA synthesis, metabolism, photosynthesis, detoxification, and the chemical transformations of nitrogen, oxygen, and carbon molecules required for life. Many diseases are due to metal imbalances or inactivity of critical metalloenzymes. Metalloenzymes are nature’s amazing catalytic centers, transforming the most stable chemical bonds in nature, and thus are important factors for health, agriculture, and the environment. Our focus is an atomic level understanding of catalytic function. We achieved this through isolation and spectroscopic characterization of intermediates of reaction cycles of enzymes and biomimetic complexes. The metals of interest are probed with a combination of EPR, ENDOR, Mössbauer spectroscopies, or SQUID magnetization. We have developed new spectroscopic instrumentation, computer simulation software, and quantitative methodologies specifically suited to probe metalloproteins and metal complexes. Some of the complexes under study are: Dioxygenases, important the in production of an essential metabolite (NAD) and in aromatic ring-opening reactions in nature. The b6f complex of oxygenic photosynthesis, important in the generation of an electrochemical gradient to drive chemical processes. Multi-heme enzymes important in the metabolic processing of N-containing compounds in nature. Biomimetic complexes related to O2 activation.

近期论文

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M. Zhu, C.M. Aikens, M.P. Hendrich, R. Gupta, H. Qian, G.C. Schatz, R. Jin. "Reversible Switching of Magnetism in Thiolate-Protected Au25 Superatoms." J. AM. CHEM. SOC. 2009, 131, 2490-2492. W.A. Gunderson, A.I. Zatsman, J.P. Emerson, E.R. Farquhar, L. Que, J.D. Lipscomb, M.P. Hendrich. "Electron Paramagnetic Resonance Detection of Intermediates in the Enzymatic Cycle of an Extradiol Dioxygenase." J. AM. CHEM. SOC. 2008, 130, 14465-14467. R. Miao, M. Martinho, J.G. Morales, H. Kim, E.A. Ellis, R. Lill, M.P. Hendrich, E. Munck, P.A. Lindahl. "EPR and Mossbauer Spectroscopy of Intact Mitochondria Isolated from Yah1p-Depleted Saccharomyces cerevisiae." Biochemistry 2008, 47, 9888-9899. R.L. Shook, W.A. Gunderson, J. Greaves, J.W. Ziller, M.P. Hendrich, A.S. Borovik. "A Monomeric MnIII-Peroxo Complex Derived Directly from Dioxygen." J. AM. CHEM. SOC. 2008, 130, 8888-8889. H.J. Kim, A. Zatsman, A.K. Upadhyay, M. Whittaker, D. Bergmann, M.P. Hendrich, A.B. Hooper. "Membrane Tetraheme Cytochrome cm552 of the Ammonia-Oxidizing Nitrosomonas europaea: A Ubiquinone Reductase." Biochemistry 2008, 47, 6539-6551. B.N. Hudder, J.G. Morales, A. Stubna, E. Munck, M.P. Hendrich,and P.A. Lindahl. "Electron paramagnetic resonance and Moessbauer spectroscopy of intact mitochondria from respiring Saccharomyces cerevisiae." Journal of Biological Inoranic Chemistry 2007, 12, 1029-1023. A.I. Zatsman, H. Zhang, W.A. Gunderson, W.A. Cramer, and M.P. Hendrich "Heme-heme interactions in the cytochrome b6f complex: EPR spectroscopy and correlation with structure" J. AM. CHEM. SOC. 2006, 128, 14246-14247. M.P. Hendrich, W. Gunderson, R.K. Behan, M.T. Green, M.P. Mehn, T.A. Betley, C.C. Lu, and J.C. Peters "Nitrogen Fixation Special Feature: On the feasibility of N2 fixation via a single-site FeI/FeIV cycle: Spectroscopic studies of FeI(N2)FeI, FeIVN, and related species" PNAS 2006, 103, 17107-17112. M.V. Golynskiy, W.A. Gunderson, M.P. Hendrich, and S.M. Cohen "Metal Binding Studies and EPR Spectroscopy of the Manganese Transport Regulator MntR" Biochemistry 2006, 45, 15359-15372. P.J. Zinn, D.R. Powell, V.W. Day, M.P. Hendrich, T.N. Sorrell, A. S. Borovik "Pyrazolate-Bridging Dinucleating Ligands Containing Hydrogen-Bond Donors: Synthesis and Structure of Their Cobalt Analogues" Inorganic Chemistry 2006, 45, 3484-3486. R.M. Franzini, R.M. Watson, G.K. Patra, R.M. Breece, D.L. Tierney, M.P. Hendrich, C. Achim "Metal Binding to Bipyridine-Modified PNA Duplexes" Inorganic Chemistry 2006, 45, 9798-9811. T.H. Parsell, R.K. Behan, M.T. Green, M.P. Hendrich, and A.S. Borovik "Preparation and Properties of a Monomeric MnIV-Oxo Complex" J. AM. CHEM. SOC. 2006, 128, 8728-8729. A.M. Tyryshkin, R.K. Watt, S.V. Baranov, J. Dasgupta, M.P. Hendrich, and G.C. Dismukes "Spectroscopic Evidence for Ca2+ Involvement in the Assembly of the Mn4Ca Cluster in the Photosynthetic Water-Oxidizing Complex." Biochemistry. 2006, 45, 12876-12889. A.K. Upadhyay, A.B. Hooper, and M.P. Hendrich "NO reductase activity of the tetraheme cytochrome c554 of Nitrosomonas europaea." J. AM. CHEM. SOC. 2006, 128, 4330-4337. A.K. Boudalis, Y. Sanakis, F. Dahan, M.P. Hendrich, and J. Tuchagues "An Octanuclear Complex Containing the {Fe3O}7+ Metal Core: Structural, Magnetic, Mossbauer, and Electron Paramagnetic Resonance Studies" Inorganic Chemistry 2006, 45, 443-453. B.S. Pierce and M.P. Hendrich "Local and Global Effects of Metal Binding within the Small Subunit of Ribonucleotide Reductase" J. AM. CHEM. SOC. 2005, 127, 3613-3623. A. B. Hooper, D. Arciero, D. Bergmann, M. P. Hendrich, “The Oxidation of Ammonia as an Energy Source in Bacteria.” in “Respiration in Archaea and Bacteria,” D. Zannoni, ed., Vol. 16, pp.121-147, 2005, Advances in Photosynthesis and Respiration, ed. Govindjee, Ed., Springer, Dordrecht, the Netherlands. C.E. MacBeth, R. Gupta, K.R. Mitchell-Koch, V.G. Young, G.H. Lushington, W.H. Thompson,M.P. Hendrich, and A. S. Borovik "Utilization of Hydrogen Bonds To Stabilize M-O(H) Units: Synthesis and Properties of Monomeric Iron and Manganese Complexes with Terminal Oxo and Hydroxo Ligands" J. AM. CHEM. SOC. 2004, 126, 2556-2567. A.P. Golombek and M.P. Hendrich "Quantitative Anaylsis of Dinuclear Mn(II) EPR Spectra" J. Magn. Reson. 2003, 165, 33-48. B. S. Pierce, T. E. Elgren, M. P. Hendrich, “Mechanistic Implications for the Formation of the Diiron Cluster in Ribonucleotide Reductase Provided by Quantitative EPR Spectroscopy” J. Am. Chem. Soc. 2003; 125, 8748-8759.