Stein , Mary-Pat - California State University, Northridge

研究领域

My research focuses on the molecular mechanisms of intracellular trafficking with particular emphasis on the ability of pathogens to alter normal cellular trafficking events to evade clearance by the host. Legionella pneumophila, the causative agent of Legionnaire’s disease, is a gram-negative bacterium that lives in fresh water amoeba and which can also invade human macrophages in the lung. L. pneumophila inhibits normal intracellular transport to lysosomes where the bacteria would be destroyed and then recruits host cell ER-derived vesicles to its vacuolar membrane. Both of these processes are dependent on the expression of a functional type IV secretion apparatus called the Dot/Icm system. This apparatus allows Legionella to inject bacterial effector proteins in the host cell cytosol. Remodeling of the L. pneumophila-containing vacuole creates an intracellular environment permissive for bacterial growth. My laboratory is currently working on identifying the L. pneumophila proteins responsible for the recruitment and fusion of host cell vesicles to the vacuolar membrane.

近期论文

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Thyagarajan, K., and M.-P. Stein, 2008. Rab 35. UCSD-Nature Molecule Pages, Rab35 Molecule Page. Cao, C., Laporte, J., Backer, J.M., Wandinger-Ness. A., and M.-P. Stein. 2007. Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes. Traffic, 8:1052-1067. [pdf] Bang, R., Marnell, L., Mold, C., Stein, M.-P., DuClos, K.T., Chivington-Buck, C., and T.W. DuClos, 2005. Analysis of binding sites in human C-reactive protein for FcgRI, FcgRIIA and C1q by site-directed mutagenesis. J. Biol. Chem., 280:25095-25102. [pdf] Leslie, K.K., Stein, M.-P., Kumar, N.S., Dai, D., Stephens, J., Wandinger-Ness, A., Glueck, D.H. 2005. Progesterone receptor isoform identification and subcellular localization in endometrial cancer. Gyn. Onc. 96:32-41. [pdf] Kagen, J.C., Stein, M.-P., Pypaert, M., and C.R. Roy. 2004. Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle. J. Exp. Med. 199:1201-1211. [pdf] Stein, M.-P., Feng, Y., Cooper, K.L., and A.Wandinger-Ness. 2003. Human VPS34 and p150 are rab7 interacting partners. Traffic 4:754-771. [pdf] Stein, M.-P., Edberg, J.C., Kimberly, R.P., Mangan, E.K., Bharadwaj, D., Mold, C., and T.W. Du Clos. 2000. C-reactive protein binding to FcgRIIa on human monocytes and neutrophils is allele specific. J. Clin. Invest.105:369-376. [pdf] Stein, M.-P., Mold, C., and T.W. Du Clos. 2000. C-reactive protein binding to murine leukocytes requires Fcg receptors. J. Immunol. 164:1514-1520. [pdf] Bharadwaj, D., Stein, M.-P., Volzer, M., Mold, C., and T.W. Du Clos. 1999. The major receptor for C-reactive protein on leukocytes is Fc receptor II. J. Exp. Med. 190:585-590. [pdf] Worsham, P.L., Stein, M.-P., and S.L. Welkos. 1995. Construction of defined F1 negative mutants of virulent Yersinia pestis. Contr. Micro. Immunol. 13:325-328. Novak, J.M., Stein, M.-P., Little, S.F., Leppla, S.H., and A.M. Friedlander. 1992. Functional characterization of protease-treated Bacillus anthracis protective antigen. J. Biol. Chem. 267:17186-17193.