Mackelprang, Rachel - California State University, Northridge

研究领域

Exobiology We study permafrost as a model for exobiology. Exobiology is the study of the orgin, evolution, and distribution of life in the universe. Many of the planets, moons, comets, and asteroids in our solar system are cryogenic. If life is found beyond Earth there is a strong possibility it will be in a cryogenic system. By understanding how life adapts to the stresses associated with frozen conditions over geological time, we will gain insight into how life elsewhere in the universe, if it exists, adapts and survives. Climate Change Permafrost soils contain approximately 25-50% of the total global soil carbon pool, nearly double the atmospheric carbon reservoir. The carbon is largely protected from microbial decomposition by frozen conditions, but climate change is threating to induce large-scale permafrost thaw exposing it to degradation. The resulting production of globally significant quantities greenhouse gasses (GHGs)—including CO2, CH4, and N2O—produce a positive feedback loop amplifying the effects of global warming. We seek to determine how microbial communities respond to permafrost thaw and to link microbial processes to carbon transformation and greenhouse gas emissions. Other Topics Other ongoing research in the lab includes antibiotic resistance in microbial communities, agriculturally relevant prairie soils in the midwestern United States, and rhizosphere communities in different grape vine varieties.

近期论文

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Mackelprang R, Jacobsen CS, Jansson JK, Tas N. Permafrost meta-omics and climate change. Annual Reviews of Earth and Planetary Sciences. Accepted for publication Hultman J, Waldrop MP, Mackelprang R, et al. Multi-omics of permafrost, active layer, and thermokarst bog soil microbiomes. Nature 2015; 521:208-212 Prestat E, David MM, Hultman J, Tas N, Lamendella R, Dvornik J, Mackelprang R, et al. FOAM (Functional Ontology Assignments for Metagenomes): a Hidden Markov Model (HMM) database with environmental focus. Nucleic Acids Research 2014: doi: 10.1093/nar/gku702 Juarez M, Reyes M, Coleman T, Rotenstein L, Sao S, Martinez D, Jones M, Mackelprang R, De Bellard ME. Characterization of the trunk neural crest in the bamboo shark, Chiloscyllium punctatum. J Comp Neurol 2013; 521: 3303-20 Mackelprang R, Waldrop MP, DeAngelis KM, Chavarria K, Blazewicz SJ, Rubin EM, Jansson JK. Metagenomic analysis of a permafrost microbial community reveals a rapid response to thaw. Nature 2011; 480:368-371 Graham DE, Wallenstein MD, Vishnivetskaya TA, Waldrop MP, Phelps TJ, Pfiffner SM, Onstott TC, Whyte LG, Rivkina E, Gilichinsky DA, Elias DA, Mackelprang R, VerBerkmoes NC, Hettich RL, Wagner DW, Wullschleger SD, Jansson JK. Microbes in the thawing permafrost: The unknown variable in the climate change equation. ISME Journal 2012; 6:709-712 Mason OU, Hazen TC, Borglin S, Chain P, Dubinsky EA, Fortney J, Han J, Holman H-YN, Hultman J, Lamendella R, Mackelprang R, Tom LM, Tringe SG, Woyke T, Zhou J, Rubin EM, Jansson JK. Metagenome, metatranscriptome and single-cell sequencing reveal microbial response to Deepwater Horizon oil spill. ISME Journal 2012; 6:1715-1727 Gilbert JA, Meyer F, Antonopoulos D, Balaji P, Brown CT, Brown CT, Desai N, Eisen JA, Evers D, Field D, Feng W, Huson D, Jansson J, Knight R, Knight J, Kolker E, Konstantindis K, Kostka J, Kyrpides N, Mackelprang R, McHardy A, Quince C, Raes J, Sczyrba A, Shade A, Stevens R. Meeting report: the terabase metagenomics workshop and the vision of an Earth microbiome project. Stand Genomic Sci. 2010; 3:243-248 Mackelprang R, Rubin E. New tricks with old bones. Science 2008; 321:211-212 Mackelprang R, Livingston RJ, Eberle MA, Carlson CS, Yi Q, Akay JM, Nickerson DA. Sequence diversity, natural selection and linkage disequilibrium in the human T cell receptor alpha/delta locus. Hum Genet 2006; 119:255-266 Yvert G, Brem RB, Whittle JW, Akey JM, Foss E, Smith EN, Mackelprang R, Kruglyak L. Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nat Genet 2003; 35:57-64 Mackelprang R, Carlson CS, Subrahmanyan L, Livingston RJ, Eberle MA, Nickerson DA. Sequence variation in the human T-cell receptor loci. Immunol Rev 2002; 190:26-39 Mackelprang R, Dearing MD, St Jeor S. High prevalence of Sin Nombre virus in rodent populations, central Utah: a consequence of human disturbance? Emerg Infect Dis 2001; 7:480-482.