Loza-Coll, Mariano A - California State University, Northridge

研究领域

The Loza-Coll Lab is broadly interested in the genetic mechanisms that control fate decisions in stem cells, under normal conditions or following diverse forms of physiological stress. In order to tackle this overarching “Big Picture” biological question, we work on several specific projects: Gut stem cells Testis stem cells Genetic Networks and Bioinformatics Stem Cells and Stress But these projects are constantly evolving, based on new discoveries in the field, our own findings and, most importantly, new questions or approaches that our students may bring to the lab. So, if you have an idea for a project that you would like to discuss, speak up – we’ll listen.

近期论文

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Loza-Coll M.A., Jones D.L. Simultaneous control of stemness and differentiation by the transcription factor Escargot in adult stem cells: How can we tease them apart? Fly (Austin). 2016 Apr 2;10(2):53-9. Loza-Coll MA, Southall TD, Sandall SL, Brand AH and Jones DL. Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot. EMBO J. 2014 Dec 17;33(24):2983-96 Korzelius J, Naumann SK, Loza-Coll MA, Chan JS, Dutta D, Oberheim J, Gläßer C, Southall TD, Brand AH, Jones DL, Edgar BA. (2014) Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells. EMBO J. 2014 Dec 17;33(24):2967-82. Voog J, Sandall SL, Hime GR, Resende LP, Loza-Coll M, Aslanian A, Yates JR III, Hunter T, Fuller MT, Jones DL. Escargot restricts niche cell to stem cell conversion in the Drosophila testis. Cell Rep. 2014 May 8;7(3):722-34. Solek CM, Oliveri P, Loza-Coll M, Schrankel CS, Ho EC, Wang G, Rast JP. An ancient role for Gata-1/2/3 and Scl transcription factor homologs in the development of immunocytes. Dev Biol. 2013 Oct 1;382(1):280-92. Toledano H, D’Alterio C, Loza-Coll M & D Leanne Jones (2012). Dual fluorescence detection of protein and RNA in Drosophila tissues. Nature Protocols 2012 Oct; 7(10):1808-17. Rast JP, Smith LC, Loza-Coll M, Hibino T, Litman GW (2006). Genomic insights into the immune system of the sea urchin. Science. Nov 10;314(5801):952-6. Sea Urchin Genome Sequencing Consortium (2006). The genome of the sea urchin Strongylocentrotus purpuratus. Science. Nov 10;314(5801):941-52. Hibino T*, Loza-Coll M*, Messier C, Majeske AJ, Cohen AH, Terwilliger DP, Buckley KM, Brockton V, Nair SV, Berney K, Fugmann SD, Anderson MK, Pancer Z, Cameron RA, Smith LC, Rast JP (2006). The immune gene repertoire encoded in the purple sea urchin genome. Dev Biol. Dec 1;300(1):349-65. [* equal contribution] Bradham CA, Foltz KR, Beane WS, Arnone MI, Rizzo F, Coffman JA, Mushegian A, Goel M, Morales J, Geneviere AM, Lapraz F, Robertson AJ, Kelkar H, Loza-Coll M, Townley IK, Raisch M, Roux MM, Lepage T, Gache C, McClay DR, Manning G (2006). The sea urchin kinome: a first look. Dev Biol. Dec 1;300(1):180-93. Lapraz F, Röttinger E, Duboc V, Range R, Duloquin L, Walton K, Wu SY, Bradham C, Loza Coll MA, Hibino T, Wilson K, Poustka A, McClay D, Angerer L, Gache C, Lepage T (2006). RTK and TGF-beta signaling pathways genes in the sea urchin genome. Dev Biol. Dec 1;300(1):132-52. Van Slyke P, Coll ML, Master Z, Kim H, Filmus J, Dumont DJ (2005). Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk. Mol Cell Biol 25(9):3831-41.Loza-Coll MA, Perera S §, Shi W, Filmus J (2005). A transient increase in the activity of Src-family kinases induced by cell detachment delays anoikis of intestinal epithelial cells. Oncogene 24(10):1727-37. [§ undergraduate author] Coll ML, Rosen K, Ladeda V, Filmus J (2002). Increased Bcl-xL expression mediates v-Src-induced resistance to anoikis in intestinal epithelial cells. Oncogene Apr 25;21(18):2908-13. Rosen K, Loza Coll M, Li A, Filmus J (2001). Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells. J Biol Chem Oct 5; 276(40):37273-9. Copelli SB, Loza Coll MA, Bruno OD (1999). Absence of mutations in the p53 tumor suppressor gene in non-invasive Cushing adenomas. Medicina (B Aires) 59(5 Pt 1):459-62. Loza Coll MA (1998). Behavioral responses of the common toad (Bufo arenarum) to external solutions of variable osmolarity. Development of an experimental model of aversive stimulation in the species. Honors Thesis, University of Buenos Aires, Argentina.