个人简介

B.A. magna cum laude, 1991 Bowdoin College Ph. D. 1997 Yale University Postdoctoral associate, 1997-1999 Dept of Chemical Engineering & Materials Science, University of Minnesota, NSF CAREER Award (2001); Camille Dreyfus Teacher-Scholar Award (2004); American Crystallography Association Margaret C. Etter Award (2005); College Dean’s Award for Excellence in Teaching (2005), US National Committee for Crystallography member (2006-2011), NSF-REU Program co-director (2006-)

研究领域

The Swift lab is broadly interested in understanding the nucleation, growth, phase changes and physical properties of molecular crystals. This research area has many direct applications to the medical, pharmaceutical, defense, and food-product industries. All projects are highly interdisciplinary, enabling students to gain valuable experience in at least a few different areas of chemistry and material science including x-ray crystallography, physical characterization methods, atomic force microscopy (AFM), organic synthesis, and/or computational modeling.

The Swift lab is broadly interested in understanding the nucleation, growth, phase changes and physical properties of molecular crystals. This research area has many direct applications to the medical, pharmaceutical, defense, and food-product industries. All projects are highly interdisciplinary, enabling students to gain valuable experience in at least a few different areas of chemistry and material science including x-ray crystallography, physical characterization methods, atomic force microscopy (AFM), organic synthesis, and/or computational modeling. Ongoing projects include: 1. Crystal deposition diseases/biomineralization. The formation of kidney stones, gout, and gallstones are all examples of undesirable crystallization processes. Our lab uses a variety of techniques to elucidate key steps in the development of these pathogenic deposits. We use in situ AFM to monitor the molecular-level growth of select crystal phases in order to determine how solution parameters directly affect the growth kinetics and/or mechanisms. Other studies have examined adhesion on crystal surfaces, the role of impurities, and the transformations of metastable crystal phases. 2. Template-directed nucleation. The Swift group is developing and using designer surfaces to control the phase, size, defect density and/or orientation of a wide variety of molecular crystals. The long term goal is to elucidate the interfacial requirements for heterogeneous nucleation in order to better predict crystallization of energetic materials, pharmaceuticals, and other model compounds a priori. 3. Structure-property relationships of hydrates, polymorphs and cocrystals. The Swift group is broadly interested in elucidating the fundamental structural, thermal, and mechanical properties of hydrates and/or polymorphic forms in a range of model and industrially-relevant compounds.

近期论文

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Jessica H. Urbelis, Victor G. Young and Jennifer A. Swift, “Using Solvent Effects to Guide the Design of a CL20 Cocrystal,” submitted Jessica H. Urbelis and Jennifer A. Swift, “Phase Selective Crystallization of Perylene on Monolayer Templates,” Cryst.Grow Des., in press [Link] Janeth B. Presores and Jennifer A. Swift, “Solution-Mediated Phase Transformation of Uric Acid Dihydrate,” CrystEngComm, 16, 7278-7284 (2014). [Link] Jessica H. Urbelis and Jennifer A. Swift, “Solvent Effects on the Growth Morphology and Phase Purity of CL-20,” Crystal Growth & Design, 14 (4) 1642-1649 (2014). [Link] Janeth B. Presores, Katherine E. Cromer, Christina Capacci-Daniel and Jennifer A. Swift, “Calcium Urate Hexahydrate,” Crystal Growth & Design, 13 (12), 5162-5164 (2013). [Link] Richard S. Abendan and Jennifer A. Swift, “Cholesterol Monohydrate Dissolution in the Presence of Bile Acid Salts,” Crystal Growth & Design, 13, 3596-3602 (2013). [Link] Janeth B. Presores and Jennifer A. Swift, “Adhesion Properties of Uric Acid Crystal Surfaces,” Langmuir, 28 (19), 7401-7406 (2012). [Link] Ilana G. Goldberg and Jennifer A. Swift, “New Insights into the Metastable β Form of RDX,” Crystal Growth & Design, 12 (2), 1040–1045 (2012). [Link] Clare M. Perrin and Jennifer A. Swift, “Step Kinetics on Monosodium Urate Monohydrate Single Crystal Surfaces: An in situ AFM Study,” CrystEngComm, 14 (5), 1709 – 1715 (2012). [Link] Clare M. Perrin, Mark A. Dobish*, Edward Van Keuren, and Jennifer A. Swift, “Monosodium Urate Monohydrate Crystallization,” CrystEngComm, 13 (4), 1111 – 1117 (2011). [Link] Jennifer Swift, “Crystal Growth,” CrystEngComm, 13 (4), 1059 – 1059 (2011). [Link] Amanuel Z. Zellelow, Kristin A. Cox*, Dorothy A. Fink*, Catherine E. Ford*, Kun-Hae Kim*, Ryan E. Sours and Jennifer A. Swift, "Doping Uric Acid Crystals. 2. Anhydrous Uric Acid," Crystal Growth & Design, 10 (8), 3348-3354 (2010). [Link] Amanuel Z. Zellelow, Melat Abiye*, Dorothy A. Fink*, Catherine E. Ford*, Kun-Hae Kim*, Ryan E. Sours, Clare M. Yannette and Jennifer A. Swift, "Doping Uric Acid Crystals. 1. Uric Acid Dihydrate," Crystal Growth & Design,10 (8), 3340-3347 (2010). [Link] Christina Capacci-Daniel, Karen J. Gaskell and Jennifer A. Swift, "Nucleation and Growth of Metastable Polymorphs on Siloxane Monolayer Templates," Crystal Growth & Design, 10, 2, 952-962 (2010). [Link] Amanuel Z. Zellelow, Kun-Hae Kim*, Ryan E. Sours and Jennifer A. Swift, "Solid State Dehydration of Uric Acid Dihydrate" Crystal Growth & Design, 10, 418-425 (2010).[Link] Christina Capacci-Daniel, Shoaleh Dehghan, Rupa Hiremath, Victoria M. Wurster*, Joseph A. Basile*, Amy A. Sarjeant and Jennifer A. Swift, "Halogen/Methyl Exchange in a Series of Isostructural 1,3-bis(m-Dihalophenyl)Ureas," CrystEngComm, 10, 1875-1880 (2008). [Link] Simeen Sattar, Megan J. Carroll*, Amy A. Sargeant, and Jennifer A. Swift, "Structure of lead urate and its effect on the nucleation of monosodium urate monohydrate" CrystEngComm., 10, 2, 155-157 (2008). [Link] Jennifer A. Swift, "Biomineralization of Organic Phases Associated with Human Disease," in Engineering of Crystalline Materials Properties. State of the Art in Modeling, Design and Applications, Eds. J.J. Novoa, D. Braga, L. Addadi (Springer, Dordrecht) p 449-475, 2008. Rositza I. Petrova, Rakesh Patel* and Jennifer A. Swift, "Habit Modification of Asparagine Monohydrate Crystals by Growth in Hydrogel Media," Crystal Growth & Design, 6, 12, 2709-2715 (2006). [Link] Rupa Hiremath and Jennifer A. Swift, "Directed Nucleation of Molecular Crystals on Self-Assembled Monolayer Surfaces," Mol. Cryst. Liq. Cryst., 456, 95-106 (2006).