Orchard, Alexandra - California State University, Fullerton - Department of Chemistry & Biochemistry

个人简介

Post-Doctoral Research: Emory University (Professor Dennis Liotta) Ph.D. in Medicinal Chemistry: State University of New York at Buffalo (Professor Michael Detty) B.S. in Biochemistry: State University of New York at Fredonia (Professor Michael Milligan) A.S. in Liberal Arts: State University of New York Erie Community College

研究领域

My research interest is in synthetic organic medicinal chemistry, specifically the design and synthesis of small molecule α-helix mimetics for targeting the E6 oncoprotein in high risk strains of human papillomavirus (HPV). Computational docking experiments aid in our design of novel classes of α-helix mimetic drugs. We use organic synthetic chemistry to make target compounds that will be tested for their potency against HPV-16 E6 in collaboration with biochemical research groups. We can also append photosensitizing moieties to compounds showing activity in an effort to make drugs useful for photodynamic inactivation (PDI) of the virus.

近期论文

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Sabatini, R. P., Eckenhoff, W. T., Orchard, A., Liwosz, K. R., Detty, M. R., Watson, D. F., McCamant, D.W., & Eisenberg, R. From Seconds to Femtoseconds: Solar Hydrogen Production and Transient Absorption of Chalcogenorhodamine Dyes. Journal of the American Chemical Society, 2014, 136 (21), 7740 - 7750 Orchard, A., Schamerhorn, G. A., Calitree, B. D., Sawada, G. A., Loo, T. W., Claire Bartlett, M., Clarke, D.M., & Detty, M. R. Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1). Bioorganic & Medicinal Chemistry, 2012, 20 (14), 4290-4302. Orchard, A., Mulhern, K. R., Watson, D. F., Detty, M. R. Influence of Surface -attachment Functionality on the Aggregation, Persistence, and Electron- Transfer Reactivity of Chalcogenorhodamine Dyes on TiO2. Langmuir, 2012, 28 (17), 7071-7082. McCormick, T. M., Calitree, B. D., Orchard, A., Kraut, N. D., Bright, F. V., Detty, M. R., & Eisenberg, R. Reductive side of water splitting in artificial photosynthesis: New homogeneous photosystems of great activity and mechanistic insight. Journal of the American Chemical Society, 2010, 132(44), 15480-15483.