个人简介

PhD, (summa cum laude) Eotvos Lorand University, Budapest, Hungary, 1979

研究领域

Analytical chemistry, Biomedical analysis, Physical chemistry, and Proteomics & metabolomics

Akos Vertes research interests span from fundamental studies in analytical and physical chemistry to the development of new technologies for biomedical analysis. He is a co-founder and co-director of the W. M. Keck Institute for Proteomics Technology and Applications, a center of strategic excellence at the university. Recent accomplishments include the introduction of photonic ion sources based on nanostructures, the introduction of a new ambient ion source called laser ablation electrospray ionization (LAESI), metabolic imaging of live plant organs and the in situ mass spectrometric analysis of single cells. His research has been presented in over 110 peer-reviewed publications, in two books, the first on laser ionization and the second on the medical applications of mass spectrometry, which he co-edited and co-authored, and in numerous conference presentations. He is an internationally recognized expert in bioanalytical methods. The research in his laboratory has been funded by the National Science Foundation, the Department of Energy, the National Institutes of Health and the W.M. Keck Foundation. His honors and awards include the Oscar and Shoshana Trachtenberg Prize for Scholarship, Fellow of the Royal Flemish Academy for Science and the Arts in Brussels, Belgium, the Doctor of the Hungarian Academy of Sciences in Budapest, Hungary, Visiting Professor of the Swiss Federal Institute of Technology in Zurich, Switzerland, the Elsevier/Spectrochimica Acta Award, Member of the News & Features Advisory Panel for the journal Analytical Chemistry and Member of the Science Advisory Board of Protea Biosciences, Inc., Morgantown, WV.

近期论文

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Rohit Shroff, Katharina Schramm, Verena Jeschke, Peter Nemes, Akos Vertes, Jonathan Gershenzon and Ales Svatos, “Quantification of plant surface metabolites by MALDI mass spectrometry imaging: glucosinolates on Arabidopsis thaliana leaves,” The Plant Journal, 2015, 81, 961-972. Laine R. Compton, Brent Reschke, Jordan Friend, Matthew Powell and Akos Vertes, “Remote Laser Ablation Electrospray Ionization Mass Spectrometry for Non-proximate Analysis of Biological Tissues,” Rapid Commun. Mass Spectrom., 2015, 29, 67-73. Hang Li, Brian K. Smith, Laszlo Mark, Peter Nemes, Javad Nazarian, and Akos Vertes, “Ambient Molecular Imaging by Laser Ablation Electrospray Ionization Mass Spectrometry with Ion Mobility Separation,” Int. J. Mass Spectrom., 2015, 375, 681-689. Bindesh Shrestha, Prabhakar Sripadi, Brent R. Reschke, Holly D. Henderson, Matthew J. Powell, Sally A. Moody and Akos Vertes, “Subcellular Metabolite and Lipid Analysis of Xenopus laevis Eggs by LAESI Mass Spectrometry,” PLoS ONE, 2014, 9, e115173. Sylwia A. Stopka, Bindesh Shrestha, Éric Maréchal, Denis Falconet and Akos Vertes, “Metabolic Transformation of Microalgae Due to Light Acclimation and Genetic Modifications Followed by Laser Ablation Electrospray Ionization Mass Spectrometry with Ion Mobility Separation,” Analyst, 2014, 139, 5945-5953. Anu Vaikkinen, Bindesh Shrestha, Juha Koivisto, Risto Kostiainen, Akos Vertes and Tiina J. Kauppila, “Laser Ablation Atmospheric Pressure Photoionization Mass Spectrometry Imaging of Phytochemicals from Sage Leaves,” Rapid Commun. Mass Spectrom., 2014, 28, 2490-2496. Linwen Zhang, Daniel P. Foreman, Paaqua A. Grant, Bindesh Shrestha, Sally A. Moody, Florent Villiers, June M. Kwak and Akos Vertes, “In Situ Metabolic Analysis of Single Plant Cells by Capillary Microsampling and Electrospray Ionization Mass Spectrometry with Ion Mobility Separation,” Analyst, 2014, 139, 5079-5085. Elizabeth Jaworski, Aarthi Narayanan, Rachel Van Duyne, Shabana Shabbeer-Meyering, Sergey Iordanskiy, Mohammed Saifuddin, Ravi Das, Philippe V. Afonso, Gavin C. Sampey, Myung Chung, Anastas Popratiloff, Bindesh Shrestha, Mohit Sehgal, Pooja Jain, Akos Vertes, Renaud Mahieux, and Fatah Kashanchi, “Human T-lymphotropic Virus Type 1-infected Cells Secrete Exosomes That Contain Tax Protein,” J. Biol. Chem., 2014, 289, 22284-22305. Bindesh Shrestha and Akos Vertes, “High-Throughput Cell and Tissue Analysis with Enhanced Molecular Coverage by Laser Ablation Electrospray Ionization Mass Spectrometry Using Ion Mobility Separation,” Anal. Chem., 2014, 86, 4308-4315. B. Shrestha, R. Javonillo, J. R. Burns, Z. Pirger, and A. Vertes, “Comparative local analysis of metabolites, lipids and proteins in intact fish tissues by LAESI mass spectrometry,” Analyst, 2013, 138, 3444-3449. J. Stolee, and A. Vertes, “Toward Single-Cell Analysis by Plume Collimation in Laser Ablation Electrospray Ionization Mass Spectrometry,” Anal. Chem., 2013, 85, 3592-3598. Deepa Raghu, Qi Xia, Linwen Zhang, Akos Vertes and Mark M. Reeves, “In-vitro sub-cellular sampling of metabolites in biological samples,” 2013 Microsystems For Measurement and Instrumentation (MAMNA), 2013, 28-30. B. N. Walker, C. Antonakos, S. T. Retterer, and A. Vertes, “Metabolic Differences in Microbial Cell Populations Revealed by Nanophotonic Ionization,” Angew. Chem. Int. Ed., 2013, 52, 3738-3741. A. Vaikkinen, B. Shrestha, J. Nazarian, R. K. Kostiainen, A. Vertes, and T. J. Kauppila, “Simultaneous Detection of Nonpolar and Polar Compounds by Heat-Assisted Laser Ablation Electrospray Ionization-Mass Spectrometry,” Anal. Chem., 2013, 85, 177-184. J. A. Stolee, B. Shrestha, G. Mengistu, and A. Vertes, “Observation of Subcellular Metabolite Gradients in Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry,” Angew. Chem. Int. Ed., 2012, 51, 10386-10389. B. N. Walker, J. A. Stolee and A. Vertes, “Nanophotonic Ionization for Ultratrace and Single-Cell Analysis by Mass Spectrometry,” Anal. Chem. 2012, 84, 7756-7762. J. A. Stolee, B. N. Walker, V. Zorba, R. E. Russo and A. Vertes, “'Laser-nanostructure Interactions for Ion Production,” Phys. Chem. Chem. Phys., 2012, 14, 8453-8471. A. Vertes, V. Hitchins and K. S. Phillips, “Analytical Challenges of Microbial Biofilms on Medical Devices,” Anal. Chem., 2012, 84, 3858-3866. A. Vaikkinen, B. Shrestha, T. J. Kauppila, A. Vertes and R. K. Kostiainen, “Infrared laser ablation atmospheric pressure photoionization mass spectrometry,” Anal. Chem., 2012, 84, 1630-1636. P. Nemes, H. Huang and A. Vertes, “Internal energy deposition and ion fragmentation in atmospheric-pressure mid-infrared laser ablation electrospray ionization,” Phys. Chem. Chem. Phys., 2012, 14, 2501-2507.