个人简介

BA, Williams College, 1996 PhD, University of Madison-Wisconsin, 2002

研究领域

Biomaterials and Biophysics, Vesicle deformation, Bilayer intercalation and Domain meta stability

The cell membrane is a complex assortment of actors. Also, as the gateway and guardian to the interior cell, it accommodates ever changing physical and chemical environments. The lipids and cholesterol components form a fluid matrix for the various transmembrane proteins and receptors to inhabit. The relationship between the lipid bilayer and membrane proteins is not well-understood even ~35 years after Singer and Nicolson first described the membrane as a fluid mosaic. Lipid organization in rafts, clusters or nano-domains, or lack there of, is the subject of constant debate with many competing theories. We pursue several strategies to understand membrane behavior. First, we explore lipid dynamics between fluid-ordered and fluid-disordered phases. Meta-stable phase configurations arise near miscibility points in the phase diagram. We have also observed meta-stability when we cross-link lipids (collaborators, F. Baginiski and X. Ren, Mathematics). Second, we have begun analyzing membrane behavior when additives intercalate in the vesicle, mapping phase shifts as a function of additive concentration. Third, in a joint effort with the Miller lab, we probe nanoparticle interactions with vesicles as models of cell membranes.

近期论文

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Numerical Investigations on the Role of Membrane Curvature in Strong Segregation Problems Frank Baginski, Susan Gillmor, Roberto Croce, Rolf Krause Applied Mathematics and Computation, 227 (15) 399-411 (2014). Long-Term Reduction in Poly(dimethylsiloxane) Surface Hydrophobicity via Cold-Plasma Treatments B.J. Larson, S.D. Gillmor, J.M. Braun, L.E. Cruz-Barba, D.E. Savage, F.S. Denes, and M.G. Lagally Langmuir, 29 (42) 12990–12996 (2013). Characterization and Performance of Short Cationic Antimicrobial Peptide Isomers Juba,M; Porter, D.; Dean, S.; Van Hoek, M.; Gillmor, S. D. and Bishop, B. (2013), Biopolymers: Peptide Science 100 (4) 387–401 (2013). Polka-Dotted Vesicles: Lipid Bilayer Dynamics and Cross-linking Effects. Kessler, M.; Samuel, R.; Gillmor, S. D., Langmuir 29 (9), 2982-2991 (2013). The Role of Gauss Curvature in a Membrane Phase Separation Problem. Gillmor, S. D.; Lee, J.; Ren, R., Physica D: Nonlinear Phenomena 240, 1913 (2011). Temperature-Dependent Vesicle Response to Surface Topography. S. D. Gillmor, J. J. Heetderks, P. S. Weiss, J Phys Chem B 113, 11490 (2009). Dimpled Vesicles: The Interplay between Interfaces and Transient Pores. S. D. Gillmor, P. S. Weiss, J Phys Chem B 112, 13629 (2008). Microcontact Insertion Printing, T. J. Mullen, C. Srinivasan, J. N. Hohman, S. D. Gillmor, M. J. Shuster, Mark W. Horn, A. M. Andrews and P. S. Weiss, Applied Physics Letters 90, 063114 (2007). Displaceable Monolayers and Microdisplacement Printing: 1-Adamantanethiol Assembly and Application, T. J. Mullen, J. N. Hohman, A. A. Dameron, J. R. Hampton, S. D. Gillmor, and P. S. Weiss, Materials Matters 1 (2), 8 (2006). Unrefereed publication. Enhanced Molecular Patterning via Microdisplacement Printing, A. A. Dameron, J. R. Hampton, S. D. Gillmor, J. N. Hohman, and P. S. Weiss, Journal of Vacuum Science and Technology B 23, 2929 (2005). Microdisplacement Printing, A. A. Dameron, J. R. Hampton, R. K. Smith, T. J. Mullen, S. D. Gillmor, and P. S. Weiss, Nano Letters 5, 1834 (2005). Controlled Deposition of Picoliter Amounts of Fluid Using an Ultrasonically Driven Micropipette, B. J. Larson, S. D. Gillmor, and M. G. Lagally Review of Scientific Instruments 75(4), 832-836 (2004). Computation with DNA on Surfaces, S. D. Gillmor, P. Rugheimer, and M. G. Lagally, Surface Science 500, 699 (2002). Hydrophilic/hydrophobic patterned surfaces as templates for DNA arrays, S. D. Gillmor, A. J. Thiel, T. C. Strother, L. M. Smith, and M. G. Lagally, Langmuir, 16, 7223 (2000). Progress toward demonstration of a surface based DNA computation: a one word approach to solve a model satisfiability problem, Q.H. Liu, A. G. Frutos, L. M. Wang, T. J. Thiel, S. D. Gillmor, T. C. Strother, A. E. Condon, R. M. Corn, M. G. Lagally, L. M. Smith, Biosystems, 52, 25 (1999). Surface-based DNA computing operations: DESTROY and READOUT, L. M. Wang, Q.H. Liu, A. G. Frutos, T. J. Thiel, S. D. Gillmor, T. C. Strother, A. E. Condon, R. M. Corn, M. G. Lagally, L. M. Smith, Biosystems, 52, 189 (1999). Characterization of chain molecular assemblies in long-chain, layered silver thiolates: A joint infrared spectroscopy and x-ray diffraction study, A.N. Parikh, S. D. Gillmor, J. D. Beers, K. M. Beardmore, R. W. Cutts , B. I. Swanson, Journal of Physical Chemistry B 103(15),2850-2861, (1999).