个人简介

BA, University of Virginia (1993) PhD, Virginia Commonwealth University (1999) Postdoc, University of Pennsylvania (1999-2001) Research Fellow, National Institutes of Health (2001-2007) Assistant Professor, George Washington University (2007-2014) Associate Professor, George Washington University (2014-present)

研究领域

Organic Synthesis, Medicinal Chemistry, Antibiotic and Antiviral Drug Discovery, and Structure-Guided Ligand Design

The development of resistance to current antibiotic therapies and the use of microorganisms in biological warfare have shown the weaknesses in our antibiotic and antiviral drugs. Now, more than ever, a need for novel therapies exists. A major limitation in the development of novel antiinfectives is the identification of an appropriate biochemical target. Our research program focuses on the development of inhibitors for specific targets implicated in the survival of certain bacteria. We are focused on Mycobacterium tuberculosis, causing TB, and identifying vulnerabilities in mycobacterial metabolism that might be targeted by small molecule therapeutic agents. Our work uses structure-guided ligand design, organic synthesis, and evaluation to examine these molecules and validate the biochemical target. Current Research Cynthia Dowd is currently engaged in several interdisciplinary projects related to antibiotic drug discovery and structure-based design. She enjoys collaboration with scientists in a variety of fields from several institutions and backgrounds. Students in her lab gain hands-on experience in molecular modeling, design, synthesis, and biochemical evaluation. Knowledge of diverse tools and thinking prepares them well for a future in science.

近期论文

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Jackson, E.J.; Dowd, C.S.* Inhibitors of 1-Deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr): A Review of the Synthesis and Biological Evaluation of Recent Inhibitors, Curr. Topics Med. Chem., 2012, 12, 706-728. McKenney, E.S.; Sargent, M.; Khan, H.; Couch, R.D.; Uh, E.; Jackson, E.R.; San Jose, G.; Dowd, C.S.; van Hoek, M.L. Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy, PLoS One, 2012, 7, e38167. Uh, E.; Jackson, E.R.; San Jose, G.; Maddox, M.; Lee, R.E.; Lee, R.E.; Boshoff, H.I.; Dowd, C.S.* Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs, Bioorg. Med. Chem. Lett., 2011, 21, 6973-6976. Kim, P.; Zhang, L.; Manjunatha, U.H.; Singh, R.; Patel, S.; Jiricek, J.; Keller, T.H.; Boshoff, H.I.; Barry, III, C.E.; Dowd, C.S.* Structure-activity relationships of antitubercular nitroimidazoles. I. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles, J. Med. Chem. 2009, 52, 1317-1328.