Heinrich, Markus - Friedrich-Alexander-Universität Erlangen-Nürnberg

个人简介

Since 2009 Associate Professor (W2) of Pharmaceutical Chemistry, University of Erlangen-Nürnberg 2005-2009 Habilitation in Organic Chemistry with Prof. Dr. Thorsten Bach, Prof. Dr. Horst Kessler and Prof. Dr. Hans-Jürgen Wester, Technische Universität München Liebig fellowship (Fonds der Chemischen Industrie), ADUC-Jahrespreis für Habilitanden 2008 2003-2005 Postdoctoral studies with Prof. Dr. Samir Z. Zard, Ecole Polytechnique, Palaiseau, France, Alfred Kastler fellowship (Service pour la Science et la Technologie): "Studies on the reactivity of acyl radicals and development of new methods for organic synthesis" 2000-2003 Ph.D. in Organic Chemistry with Prof. Dr. Wolfgang Steglich, Ludwig-Maximilians-Universität München: "Synthesis of halitulin, haliclorensin and related alkaloids and amino acids" 1999-2000 Diplomarbeit in the workgroup of Prof. Dr. Wolfgang Steglich, LMU München: "Synthesis of new tyrosine derivatives and heterocycles from 3-aminotyrosine" 1995-2000 Studies for Diplom-Chemie at the LMU München 1994-1995 Medical service at the military bases Feldkirchen and Murnau 1985-1994 Wernher-von-Braun Gymnasium, Friedberg Scholarship "Studienstipendium des bayerischen Staates" 1981-1985 Primary school, Derching 1975 born in Augsburg

研究领域

Radical chemistry, environmental chemistry, synthesis of bioactive compounds, radiopharmacy

近期论文

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Fluoro-substituted phenylazocarboxamides: dopaminergic behavior and N-arylating properties for irreversible binding A. L. Bartuschat, T. Schellhorn, H. Hübner, P. Gmeiner, M. R. Heinrich, Bioorg. Med. Chem. 2015, published online DOI: 10.1016/j.bmc.2014.12.012 How the structural elucidation of the natural product stephanosporin led to new developments in aryl radical and medicinal chemistry S. K. Fehler, M. R. Heinrich, Synlett 2015, 26, 580-603 (account article) DOI: 10.1055/s-0034-1378945 Synthesis of dibenzo[c,e][1,2]diazocines - a new group of eight-membered cyclic azo compounds T. Nokubi, S. Kindt, T. Clark, A. Kamimura, M. R. Heinrich, Tetrahedron Lett. 2015, 56, 316-320 DOI: 10.1016/j.tetlet.2014.11.064 Synthesis and evaluation of fluoro substituted pyridinylcarboxamides and their phenylazo analogues as potential dopamine D3 receptor PET ligands N. Nebel, S. Maschauer, A. L. Bartuschat, S. K. Fehler, H. Hübner, P. Gmeiner, T. Kuwert, M. R. Heinrich, O. Prante, C. Hocke, Bioorg. Med. Chem. Lett. 2014, 24, 5399-5403 DOI: 10.1016/j.bmcl.2014.10.043 Intermolecular radical carbofluorination of non-activated alkenes S. Kindt, M. R. Heinrich, Chem. Eur. J. 2014, 20, 15344-15348 DOI: 10.1002/chem.201405229 The trapping of phenyldiazenes in cycloaddition reactions S. K. Fehler, G. Pratsch, M. R. Heinrich, Angew. Chem. 2014, 126, 11543–11548, Angew. Chem. Int. Ed. 2014, 53, 11361-11365 DOI: 10.1002/ange.201406175; DOI: 10.1002/anie.201406175 Synthesis of 7-arylquinolinones and 6-arylindoles from 3-aminobiphenyls through regioselective cyclization reactions S. G. Hammer, M. R. Heinrich, Tetrahedron 2014, 70, 8114-8121 DOI: 10.1016/j.tet.2014.08.012 Radiosynthesis and validation of 18F-FP-CMT, a phenyltropane with superior properties for imaging the dopamine transporter in living brain P. Cumming, S. Maschauer, P. Riss, N. Tschammer, S. Fehler, M. R. Heinrich, T. Kuwert, O. Prante, J. Cereb. Blood Flow Metab. 2014, 34, 1148-1156 DOI: 10.1038/jcbfm.2014.63 Fixation and recycling of nitrogen monoxide through carbonitrosation reactions C. de Salas, M. R. Heinrich, Green Chem. 2014, 16, 2982-2987 DOI: 10.1039/C3GC42432D Manganese(IV)-mediated hydroperoxyarylation of alkenes with arylhydrazines and dioxygen from air S. Kindt, H. Jasch, M. R. Heinrich, Chem. Eur. J. 2014, 20, 6251–6255 DOI: 10.1002/chem.201400064 Oxidative radical arylation of anilines with arylhydrazines and dioxygen from air J. Hofmann, H. Jasch, M. R. Heinrich, J. Org. Chem. 2014, 79, 2314–2320 DOI: 10.1021/jo500063r Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and beta-aminoisobutyrate metabolism in healthy volunteers A. Kittel, F. Müller, J. König, M. Mieth, S. Bode-Böger, A. Kralj, M. R. Heinrich, M. F. Fromm, R. Maas, PLOS ONE 2014, 9, e88544 DOI: 10.1371/journal.pone.0088544 Fast and efficient 18F-labeling via [18F]fluorophenylazocarboxylic esters S. Fehler, S. Maschauer, S. Höfling, A. Bartuschat, N. Tschammmer, H. Hübner, P. Gmeiner, O. Prante, M. R. Heinrich, Chem. Eur. J. 2014, 20, 370-375 DOI: 10.1002/chem.201303409 Synthesis and biological evaluation of biphenyl amides that modulate the US28 receptor A. Kralj, E. Kurt, N. Tschammer, M. R. Heinrich, ChemMedChem 2014, 9, 151-168 DOI: 10.1002/cmdc.201300369 Aryl radicals in carbon-carbon formation S. Hammer, M. R. Heinrich, Comprehensive Organic Synthesis, Eds. G. Molander, P. Knochel, 2nd ed., Elsevier Inc., 2014 ISBN-10: 0-080-97742-1; ISBN-13: 978-0-080-97742-3 Studies on the synthesis and biosynthesis of the fungal alkaloid necatorone J. Carstens, M. R. Heinrich, W. Steglich, Tetrahedron Lett. 2013, 54, 5445-5447 DOI: 10.1016/j.tetlet.2013.07.118 Enzymatic kinetic resolution and racemization of 2-(tetramethylpiperidine-1-oxyl)ethanols A. Prechter, M. R. Heinrich, Eur. J. Org. Chem. 2013, 5585-5589 DOI: 10.1002/ejoc.201300661 Development of flavonoid-based inverse agonists of the key signaling receptor US28 of Human Cytomegalovirus A. Kralj, M.-T. Nguyen, N. Tschammer, N. Ocampo, Q. Gesiotto, M. R. Heinrich, O. Phanstiel, J. Med. Chem. 2013, 56, 5019-5032 DOI: 10.1021/jm4003457 Twofold carbon-carbon bond formation via intramolecular and intermolecular radical reactions of aryl diazonium salts H. Jasch, Y. Landais, M. R. Heinrich, Chem. Eur. J. 2013, 19, 8411-8416 DOI: 10.1002/chem.201300354 Regioselective radical arylation of anilines with arylhydrazines H. Jasch, J. Scheumann, M. R. Heinrich, J. Org. Chem. 2012, 77, 10699-10706 DOI: 10.1021/jo301980j