个人简介

2010–present Teresa Heinz Professor of Green Chemistry Carnegie Mellon University 2001–2010 Thomas Lord Professor of Chemistry, Carnegie Mellon University 1988–1992 Associate Professor of Chemistry, Carnegie Mellon University 1981–1987 Assistant Professor of Chemistry, California Institute of Technology 1978–1980 Postdoctoral Fellow, Stanford University 1978 Doctor of Philosophy, University of Auckland 1975 Master of Science with First Class Honors, University of Auckland 1974 Bachelor of Science, University of Auckland

研究领域

Bioinorganic/Catalysis/Green & Environmental/Renewable Energy

Design of Green Oxidation Catalysts We design homogeneous oxidation catalysts to activate the natural oxidants, hydrogen peroxide and oxygen. By following an iterative design protocol, we have developed TAML activators with iron as the active metal that are outstanding peroxidase mimics, but are only about 1% the size of the enzymes. Peroxidase enzymes are distributed widely in nature and activate hydrogen peroxide to oxidize organic substrates. We are continuing to develop our insight into how to control catalyst lifetime, reactivity and selectivity via ligand design and are producing new peroxidase mimics with targeted reactivity features. Students learn to design high performance oxidation catalysts and to apply synthetic organic and inorganic chemistry to enable their design work. Mechanisms of Action of Green Oxidation Catalysts In water with hydrogen peroxide (or some other oxidizing agents), TAML activators produce exceptionally strong oxidizing systems that generally perform rapidly and are capable of large turnover numbers. The reaction chemistry is usually highly efficient in hydrogen peroxide use and appears to be primarily non-radical in nature. We design ways to kinetically isolate the various steps in the complex catalytic cycle and then measure the rate behavior as we work to construct a full quantitative picture of the catalysis. Students learn how to perform kinetic studies on complex catalytic systems including stopped-flow and conventional techniques. Developing Potential Applications of Green Oxidation Catalysts TAML activators do their catalytic work at remarkably low concentrations, low micromolar to nanomolar. By using design understanding informed by mechanistic insight, we have been able to produce variants that oxidize many pollutants in water over a wide range of reaction conditions. The list includes persistent chlorinated phenols, natural and synthetic estrogens, active pharmaceutical agents, dyes and colored lignin fragments, chemical warfare agents, persistent explosives residuals, pesticides, and colored and smelly pollutants from the pulp and paper industry. High performance disinfection of hardy pathogens including bacterial spores and clostridia has also been discovered. Students learn how to follow these processes using a range of analytical techniques.

近期论文

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Here is a sample of our recent publications:Formation of a Room Temperature Stable FeV(O) Complex: Reactivity Toward Unactivated C-H Bonds, Munmun Ghosh, Kundan K. Singh, Chakadola Panda, Andrew Weitz, Michael P. Hendrich, Terrence J. Collins, Basab B. Dhar, and Sayam Sen Gupta, J. Am. Chem. Soc., 2014, Article ASAP, DOI:10.1021/ja412537m Estimation of rate constants in nonlinear reactions involving chemical inactivation of oxidation catalysts, Maria Emelianenko, Diego Torrejon, Matthew A. DeNardo, Annika K. Socolofsky, Alexander D. Ryabov · Terrence J. Collins, J Math Chem, 2014, 52, 1460–1476 DOI 10.1007/s10910-014-0322-4 Electrocatalytic Oxygen Evolution with an Immobilized TAML Activator, Demeter, Ethan; Hilburg, Shayna; Washburn, Newell; Collins, Terrence; Kitchin, John, J. Am. Chem. Soc., 2014, 136 (15), pp 5603–5606 DOI: 10.1021/ja5015986 Zebrafish Assays as Developmental Toxicity Indicators in the Green Design of TAML Oxidation Catalysts Lisa Truong, Matthew A. DeNardo, Soumen Kundu, Terrence J. Collins, and Robert L. Tanguay, Green Chemistry, 2013, accepted for publication: DOI:10.1039/C3GC40376A Designing endocrine disruption out of the next generation of chemicals T. T. Schug, R. Abagyan, B. Blumberg, T. J. Collins, D. Crews, P. L. DeFur, S. M. Dickerson,T. M. Edwards, A. C. Gore, L. J. Guillette, T. Hayes, J. J. Heindel, A. Moores, H. B. Patisaul, T. L. Tal, K. A. Thayer, L. N. Vandenberg, J. C. Warner, C. S. Watson, F. S. vom Saal, R. T. Zoeller, K. P. O'Brien, and J. P. Myers, Green Chem., 2013,15, 181-19, DOI: 10.1039/c2gc350 TAML Activator /Peroxide Catalyzed Facile Oxidative Degradation of the Persistent Explosives Trinitrotoluene and Trinitrobenzene in Micellar Solutions Soumen Kundu, Arani Chanda, Sushil K. Khetan, Alexander D. Ryabov, and Terrence J. Collins, Environmental Science and Technology, Environ. Sci. Technol., 2013, 47 (10), pp 5319–5326, DOI: 10.1021/es400062 TAML Activator-based Amperometric Analytical Devices as Alternatives to Peroxidase Biosensors Ryabov, Alexander D.; Ceron-Camacho, Ricardo; Saavedra-Diaz, Omar; DeNardo, Matthew A.; Ghosh, Anindya; Le Lagadec, Ronan; Collins, Terrence J. From Analytical Chemistry,(2012), 84(21), 9096-9100. Experimental and Theoretical Evidence for Multiple FeIV Reactive Intermediates in TAML-Activator Catalysis: Rationalizing a Counterintuitive Reactivity Order Kundu, Soumen; Annavajhala, Medini; Kurnikov, Igor V.; Ryabov, Alexander D.; Collins, Terrence J. From Chemistry—A European Journal (2012), 18(33), 10244-10249. Facile destruction of formulated chlorpyrifos through green oxidation catalysis Kundu, Soumen; Chanda, Arani; Espinosa-Marvan, Leticia; Khetan, Sushil K.; Collins, Terrence J. From Catalysis Science & Technology (2012), 2(6), 1165-1172. Green Science & EducationCollins T. J. persuasive communication about matters of great urgency: endocrine disruption, Environ. Sci. Technol., 2008, 42(20), 7555–7558. Collins, T. J.; Walter, C. Little green molecules. Sci. Am. 2006, 294, (3), 83-88, 90 (download pdf) (download pdf of German translation). Ghosh, A.; Gupta, S. S.; Bartos, M. J.; Hangun, Y.; Vuocolo, L. D.; Steinhoff, B. A.; Noser, C. A.; Horner, D. A.; Mayer, S.; Inderhees, K.; Horwitz, C. P.; Spatz, J.; Ryabov, A. D.; Mondale, S.; Collins, T. J. Green chemistry. Sustaining a high-technology civilization, Pure Appl. Chem. 2001, 73, 113–118. Collins, T. J. Towards sustainable chemistry, Science, 2001, 291, 48 (full text). Collins, T. J. Papermaking: Green chemistry through the mill. Nature 2001, 414(6860), 161, 163.