个人简介

2010–present Research Professor, Carnegie Mellon 2005–2010 Associate Research Professor, Carnegie Mellon 1996–2005 Assistant Research Professor, Carnegie Mellon 1996–present Director, Center for Molecular Analysis 1988–1996 Scientist , ThermoFisher Scientific (Finnigan) 1983–1988 Ph.D., Purdue University 1981–1983 Scientist, AMSCO Inc. (Steris) 1980–1981 Biochemist, VA Medical Center

研究领域

Biophysical/Green & Environmental/Spectroscopy & Single Molecule Analysis

Macromolecular Mass Spectrometry for Biological Discovery (BioPhysical) Our research is focused on the development of a heavy ion mass spectrometer and methods to improve the analysis of nanoparticles such as biomacromolecular complexes (viruses, von Willebrand Factor) and nano-sized synthetic particles (Au nanoparticles). Electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) will be used to produce the heavy ions in the gas phase. The new instrument, incorporates a superconducting tunnel junction (STJ) detector that allows us to study the limitations of mass spectrometry at high m/z. This new detector technology has a tremendous advantage over conventional detectors because it is, theoretically, 100% efficient at high mass. This research is expected to impact molecular biology, virology and polymer chemistry. To date, we have recorded the highest molecular weight chains of polystyrene at 2.2 Mega-Da and, remarkably, a virus particle at 13 MegaDa by MALDI TOF MS. In the future, we expect to be able to analyze ribosomal particles, virus particles, DNA/RNA protein complexes and other nano-sized synthetic particles. Water Analysis (Environmental) The objective of our environmental work is to monitor low levels of molecules in water or air using electrospray ionization membrane introduction MS (MIMS) probes. Our MIMS probes have shown detection limit in the ppb to ppt range. Investigations into the quality of our ground water due to Marcellus shale drilling is of interest.

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Groner, M.L., L.A. Rollins-Smith, L.K. Reinert, J. Hempel, M.E. Bier, and R.A. Relyea, Interactive effects of competition and predator cues on immune responses of leopard frogs at metamorphosis., The Journal of Experimental Biology 2013. Groner, M.L., J.C. Buck, S. Gervasi, A.R. Blaustein, L.K. Reinert, L.A. Rollins-Smith, M.E. Bier, J. Hempel, and R.A. Relyea, Larval exposure to predator cues alters immune function and response to a fungal pathogen in post-metamorphic wood frogs., Ecological Applications 2013, 23(6), 1443-1454. Hovis,Kenneth R.; Ramnath, Rohit; Dahlen, Jeffrey E.; Romanova, Anna L.; LaRocca, Greg; Bier, Mark E.; Urban, Nathaniel N., Activity regulates functional connectivity from the vomeronasal organ to the accessory olfactory bulb, Journal of Neuroscience 2012, 32(23), 7907-7916. Shen, Longzhu Q; Beach Evan S; Xiang, Yan; Tshudy, Dwight J; Khanina, Natalya; Horwitz, Colin P; Bier, Mark E; Collins, Terrence, Rapid, biomimetic degradation in water of the persistent drug sertraline by TAML catalysts and hydrogen peroxide, Environmental Science & Technology 2011, 45(18), 7882-7. Qian, Huifeng; Eckenhoff, William; Bier, Mark E.; Pintauer, Tomislav; Jin, Rongchao, Crystal Structures of Au2 Complex and Au25 Nanocluster and Mechanistic Insight into the Conversion of Polydisperse Nanoparticles into Monodisperse Au25 Nanoclusters, Inorganic Chemistry, 2011 50(21), 10735-10739. Wu, Zhikun; Jiang,De-en; Lanni, Eric; Bier, Mark E.; Jin, Rongchao. Sequential Observation of AgnS4- (1 ≤ n ≤7) Gas Phase Clusters in MS/MS and Prediction of Their Structures. Journal of Physical Chemistry Letters 2010, (9),1423-1427. Stephens, Catherine H.; Shrestha, Bindesh; Morris, Hannah R.; Bier, Mark E.; Whitmore, Paul M.; Vertes, Akos. Minimally invasive monitoring of cellulose degradation by desorption electrospray ionization and laser ablation electrospray ionization mass spectrometry. Analyst 2010,135(9), 2434-2444. Wu,Zhikun; Lanni, Eric; Chen, Wenqian; Bier, Mark E.; Ly, Danith, and Jin, Rongchao "High Yield, Large Scale Synthesis of Thiolate-Protected Ag7 Clusters" Journal of the American Chemical Society. 2009,131(46), p16672-16674. Qian, Huifeng; Zhu, Manzhou; Lanni, Eric; Zhu, Yan; Bier, Mark E.; Jin, Rongchao. Conversion of polydisperse Au nanoparticles into monodisperse Au25 nanorods and nanospheres. Journal of Physical Chemistry C 2009,113(41), 17599-17603. Stephens, Catherine H.; Whitmore, Paul M.; Morris, Hannah R.; Bier, Mark E.. "Hydrolysis of the Amorphous Cellulose in Cotton-Based Paper." Biomacromolecules 2008, 9(4), 1093-1099. Zhu, Manzhou; Lanni, Eric; Garg, Niti; Bier, Mark E.; Jin, Rongchao. "Kinetically Controlled, High-Yield Synthesis of Au25 Clusters." Journal of the American Chemical Society 2008, 130(4), 1138-1139. Aksenov, Alexander A.; Bier, Mark E.. "The Analysis of Polystyrene and Polystyrene Aggregates into the Mega Dalton Mass Range by Cryodetection MALDI TOF MS." Journal of the American Society for Mass Spectrometry 2008, 19(2), 219-230. VanHassel, Emily; Bier, Mark E. "An Electrospray Membrane Probe for the Analysis of Volatile and Semi-volatile Organic Compounds in Water." Rapid Commun. Mass Spectrom. 2007; 21: 413-420. Datta, Bhaskar; Bier, Mark E.; Roy, Subhadeep and Armitage, Bruce A. "Quadruplex Formation by a Guanine-Rich PNA Oligomer." J. American Chem. Soc. 2005, 127, 4199-4207. Curten, B.; Kullmann, P.; Bier, M.E.; Kandler, K.; Schmidt, B.F. "Synthesis, Photophysical, Photochemical and Biological Properties of a stable form of caged GABA, 4-[[(2H-1-Benzopyran-2-one-7-amino-4-methoxy)carbonyl]amino] butanoic acid (BC204)" Photochemistry and Photobiology, 2005, 81(3), 641-648. Yang, Gem and Bier, Mark E. "Investigation of a Rapid Scan on an Electrospray Ion Trap Mass Spectrometer" Anal. Chem. 2005, 77, 1663-1671. Ramsey, Brian G. and Bier, Mark E. "A LDI Mass Spectrometry Investigation of Triarylboranes and Tri-9-anthrylborane Photolysis Products." Journal of Organometallic Chemistry, 2005, 609, 962-971. Balasubramani, Manimalha; Bier, Mark E.; Hummel, Susi; Schneider, Wolfgang E. and Halfter, Willi. "Perlecan and its Immunoglobulin like domain IV is abundant in vitreous and serum of the chick embryo." Matrix Biology, 2004, 23, 143-152. Bier, Mark E.; Yang, Chunguang G.; Grabowski, Joseph J. "The virtual mass spectrometry laboratory and a polymer analysis case study." Polymeric Materials Science and Engineering (2003), 88, 70. Bier, Mark E. "The basics of MALDI and ESI mass spectrometers for polymer analysis." Polymeric Materials Science and Engineering 2003, 88, 17-18.