个人简介

BS, MS - University of Rochester PhD - Case Western Reserve University Post-Doctoral Study - Case Western Reserve University and University of Colorado - Denver

研究领域

Tissue Engineering

There is a critical need for replacement tissues due to organ failure and tissue loss. The field of tissue engineering seeks to regenerate diseased or damaged tissues by providing the necessary physical, biochemical, and cellular cues that promote tissue regeneration. These approaches typically use biomaterial scaffolds, often with incorporated bioactive factors to help induce the formation of the desired tissue within a defect site. Furthermore, cells can be incorporated into the biomaterial system to help repopulate the defect with the appropriate cell type. In the body, cells are influenced by a large host of factors, including soluble signals such as growth factors, insoluble signals that are components of the extracellular matrix surrounding the cells, and also the interaction of various populations of cells with each other. Our group is interested in the development of biopolymer systems that will allow the study of cells’ interactions with their microenvironment and that can be used for both tissue regeneration and therapeutics. More specifically, we are investigating the controlled delivery of bioactive factors and therapeutics, the presentation of insoluble signals to cells, the effect of mechanical forces on cell behavior and tissue formation, and the influence that different cell populations have on one another. These advances will lead to improved biomaterial system design criteria. In addition to our tissue engineering research, we are also engineering biopolymer systems for controlled delivery of therapeutic molecules for the treatment of cancer. Ultimately, what we learn in our laboratory will help to improve patient therapies that are available in the clinic.

近期论文

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Martin J, Riederer M, Krebs MD, Erb RM. Understanding and overcoming shear alignment of fibers during extrusion. Soft Matter, 2015, 11(2), 400-5. Nguyen K, Jeon O, Krebs MD, Alsberg E. Sustained localized presentation of RNA interfering molecules from in situ forming hydrogels to guide stem cell osteogenic differentiation. Biomaterials, Aug 2014, 35(24), 6278-86. Heylman CM, Santoso S, Krebs MD, Saidel GM, Alsberg E, Muschler GF. Modeling and Experimental Methods to Predict Oxygen Distribution in Bone Defects Following Cell Transplantation. Medical & Biological Engineering & Computing, April 2014, 52(4), 321-30. Corn DJ, Kim Y, Krebs MD, Mounts T, Molter J, Gerson S, Alsberg E, Dennis JE, Lee Z. Imaging Early Stage Osteogenic Differentiation of Mesenchymal Stem Cells. Journal of Orthopaedic Research, 31(6), 871-9, June 2013. Lee Z, Dennis JE, Alsberg E, Krebs MD, Welter J, Caplan A. Imaging Stem Cell Differentiation for Cell-Based Tissue Repair. Methods in Enzymology, 506, 247-63, 2012. Jeong SI, Jeon O, Krebs MD, Hill MC, Alsberg E. Biodegradable photocrosslinked alginate nanofiber scaffolds with tunable physical properties, cell adhesivity, and growth factor release. eCells & Materials, 24, 331-43, 2012. Bonino CA, Efimenko K, Jeong SI, Krebs MD, Alsberg E, Khan SA. Three-Dimensional Electrospun Alginate Mats via Tailored Charge Repulsions. Small, 8(12), 1928-36, June 25, 2012. Jeon O, Powell C, Solorio L, Krebs MD, Alsberg E. Affinity-based growth factor delivery from biodegradable, photocrosslinked heparin-alginate hydrogels. Journal of Controlled Release, 154(3), 258-66, September 25, 2011. Jeon O, Krebs MD, Alsberg E. Controlled and sustained gene delivery from injectable, porous PLGA scaffolds. Journal of Biomedical Materials Research A, 98(1), 72-9, July 2011. Bonino CA, Krebs MD, Saquing CD, Jeong SI, Shearer KL, Alsberg E, Khan SA. Electrospinning alginate-based nanofibers: From blends to crosslinked low molecular weight alginate-only systems. Carbohydrate Polymers, 85(1), 111-119, April 22, 2011. Krebs MD, Alsberg E. Localized, Targeted and Sustained siRNA Delivery. Chemistry – A European Journal, 17, 3054-62, 2011. Jeong SI*, Krebs MD*, Bonino CA, Samorezov J, Khan SA, Alsberg E. Electrospun Chitosan-Alginate Nanofibers with In Situ Crosslinking for Use as Tissue Engineering Scaffolds. Tissue Engineering, 17(1-2), 59-70, January 2011. Jeong SI*, Krebs MD*, Bonino CA, Khan SA, Alsberg E. Electrospun alginate nanofibers with controlled cell adhesion for tissue engineering. Macromolecular Bioscience, 10(8), 934-43, August 11, 2010. Krebs MD, Salter E, Chen E, Sutter KA, Alsberg E. Calcium Phosphate – DNA Nanoparticle Gene Delivery from Alginate Hydrogels Induces in vivo Osteogenesis. Journal of Biomedical Materials Research Part A, 92A(3), 1131-1138, March 1, 2010. Krebs MD*, Sutter KA*, Lin AS, Guldberg RE, Alsberg E. Injectable Poly(lactic-co-glycolic) Acid Scaffolds with In Situ Pore Formation for Tissue Engineering. Acta Biomaterialia, 5(8), 2847-59, October 2009. Erb RM, Krebs MD, Alsberg E, Samanta B, Rotello VM, Yellen BB. Beyond diffusion-limited chain aggregation in microparticle suspensions. Physical Review E, 80(5), 051402, 2009. Krebs MD, Jeon O, Alsberg E. Localized and Sustained Delivery of Silencing RNA from Macroscopic Biopolymer Hydrogels. JACS, 131(26), 9204-06, July 8, 2009. Krebs MD*, Erb RM*, Yellen BB, Samanta B, Rotello VM, Alsberg E. Formation of ordered cellular structures in suspension via label-free negative magnetophoresis. Nano Letters, 9(5), 1812-7, May 2009. Krebs MD, Kang JJ, Cohen SJ, Lozow JB, Tingley RD, Davis CE. Two-Dimensional Alignment of Differential Mobility Spectrometer Data. Sensors and Actuators B: Chemical, 119(2), 475-482, December 7, 2006. Krebs MD*, Mansfield B*, Yip P, Cohen SJ, Sonenshein AL, Hitt BA, Davis CE. Novel Technology for Rapid Species-Specific Detection of Bacillus Spores. Biomolecular Engineering 23(2-3), 119-27, June 2006.