个人简介

BS - Northeastern University PhD - University of California, Santa Barbara Post-Doctoral Study - C.S. Draper Laboratory and Northeastern University

研究领域

Biomedical Sensors

Current molecular probes and sensor technologies present limitations in both the range of targets that can be measured and the ability to function in the complicated in vivo environment. My research program will help answer pressing biomedical questions by developing novel nanosensors that overcome these limitations and applying these new tools in situ. Traditional sensor designs, while being quite valuable for in vitro and laboratory analysis, often fail in vivo due to complications such as sensor invasiveness, sensitivity, selectivity, and limitations from the sensor readout mechanism. Polymeric nanosensors have emerged over the past several years as an excellent nanosensor design platform for continuous in vivo monitoring that overcomes the shortcoming of many traditional sensor designs. Using this platform, I will focus my research on three distinct projects for which continuous monitoring can provide valuable information. Develop Enzyme Linked Nanosensors (ELiNS) to continuously monitor lactate levels during acute liver failure. Develop peptide targeted nanosensors for pH, pO2, pCO2, and lactate to monitor tumor metabolism during treatment. Develop fluorescence lifetime based nanosensors for improved cellular imaging in biofilms.

近期论文

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Cash, KJ, Li, C, Xia, J, Wang, LV, Clark, HA, “Optical Drug Monitoring: Photoacoustic Imaging of Nanosensors to Monitor Therapeutic Lithium In Vivo“, ACS Nano, 2015, in press. http://pubs.acs.org/doi/abs/10.1021/nn5064858 Awqatty, B, Samaddar, S, Cash, KJ, Clark, HA, Dubach, JM, “Fluorescent Sensors for the Basic Metabolic Panel Enable Measurement with a Smart Phone Device Over the Physiological Range”, Analyst, 2014, 139, 5230-5238. http://pubs.rsc.org/en/content/articlelanding/2014/an/c4an00999a Cash, KJ, Clark, HA, “Phosphorescent Nanosensors for in Vivo Tracking of Histamine Levels”, Analytical Chemistry, 2013, 85, 6312-6318. PMID 23767828. http://pubs.acs.org/doi/abs/10.1021/ac400575u Cash, KJ, Clark, HA, “In Vivo Histamine Optical Nanosensors”, Sensors, 2012, 12, 11922-11932. PMID 23112690. http://www.mdpi.com/1424-8220/12/9/11922 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478817/ White, RJ, Kallewaard, HM, Hsieh, W, Patterson, AS, Kasehagen, JB, Cash, KJ, Uzawa, T, Soh, HT, Plaxco, KW, “Wash-free, Electrochemical Platform for the Quantitative, Multiplexed Detection of Specific Antibodies”, Analytical Chemistry, 2012, 84, 1098-1103. PMID 22145706. http://pubs.acs.org/doi/abs/10.1021/ac202757c http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523736/ Balaconis, MK, Billingsley, K, Dubach, M, Cash, KJ, Clark, HA, “The Design and Development of Fluorescent Nano-Optodes for in Vivo Glucose Monitoring”, Journal of Diabetes Science and Technology, 2011, 5, 1650-1657. PMID 21303627. http://jdst.org/worldpress/index.php?s=Volume+5%2C+Issue+1%3A+68+2011 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045232/ Cash, KJ, Clark, HA, “Nanosensors and Nanomaterials for Monitoring Glucose in Diabetes”, Trends in Molecular Medicine, 2010, 16, 584-593. PMID 20869318. http://www.cell.com/trends/molecular-medicine/abstract/S1471-4914(10)00114-0 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996880/ Wickersham, CE, Cash, KJ, Pfeil, SH, Bruck, I, Kaplan, DL, Plaxco, KW, Lipman, EA, “Tracking a Molecular Motor with a Nanoscale Optical Encoder”, Nano Lett., 2010, 10, 1022-1027. PMID 20121107. http://pubs.acs.org/doi/abs/10.1021/nl904192m http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842186/ Cash, KJ, Ricci, F, Plaxco, KW, “A General Electrochemical Method for Label-Free Screening of Protein-Small Molecule Interactions”, Chem. Commun. 2009, 6222-6224. PMID 19826675. http://pubs.rsc.org/en/Content/ArticleLanding/2009/CC/b911558g http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861035/ Uzawa, T, Cheng, RR, Cash, KJ, Makarov, DE, Plaxco, KW, “The Length and Viscosity Dependence of End-to-End Collision Rates in Single-stranded DNA”, Biophys. J., 2009, 97, 205-210. PMID 19580758. http://www.sciencedirect.com/science/article/pii/S0006349509009023 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711352/ Cash, KJ, Ricci, F, Plaxco, KW, “An Electrochemical Sensor for the Detection of Protein-Small Molecule Interactions Directly in Serum and Other Complex Matrices”, JACS, 2009, 131, 6955-6957. PMID 19413316. http://pubs.acs.org/doi/abs/10.1021/ja9011595 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862979/ Oh, KJ, Cash, KJ, Plaxco, KW, “Beyond Molecular Beacons: Optical Sensors Based on the Binding-Induced Folding of Proteins and Polypeptides”, Chemistry – A European Journal, 2009, 15, 2244-2251. PMID 19191230. http://onlinelibrary.wiley.com/doi/10.1002/chem.200701748/abstract http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692644/ Cash, KJ, Heeger, AJ, Plaxco, KW, Xiao, Y, “Optimization of a Reusable, DNA Pseudoknot-Based Electrochemical Sensor for Sequence-Specific DNA Detection in Blood Serum”, Analytical Chemistry, 2009, 81, 656-661. PMID 19093760. http://pubs.acs.org/doi/abs/10.1021/ac802011d http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861039/ Oh, KJ, Cash, KJ, Lubin, AA, Plaxco, KW, “Chimeric peptide beacons: a direct polypeptide analog of DNA molecular beacons”, Chem. Commun. 2007, 4869-4871. PMID 18361352. http://pubs.rsc.org/en/content/articlelanding/2007/CC/b709776j http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692638/ Oh, KJ, Cash, KJ, Hugenberg, V, Plaxco, KW, “Peptide Beacons: A New Design for Polypeptide-Based Optical Biosensors”, Bioconjugate Chem. 2007, 18, 607-609. PMID 17461545. http://pubs.acs.org/doi/abs/10.1021/bc060319u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528055/ Oh, KJ, Cash, KJ, Plaxco, KW, “Excimer-Based Peptide Beacons: A Convenient Experimental Approach for Monitoring Polypeptide-Protein and Polypeptide-Oligonucleotide Interactions”, J. Am. Chem. Soc. 2006, 128, 14018-14019. PMID 17061871. http://pubs.acs.org/doi/abs/10.1021/ja0651310