个人简介

BS - University of California, Berkeley MS, PhD - Stanford University Post-Doctoral Study - Raychem Corporation Education Abroad - Georg-August-Universität Göttingen (Germany)

研究领域

Microfluidics, Biomedical Microdevices

The controlled assembly of colloidal particles has received significant attention in recent years because of their potential application as nano- and micro-structured materials. To vary their structure and behavior, we employ external fields, including applied time-varying electromagnetic, electric, and magnetic fields. One technique that we use to great extent is optical trapping in which a “tractor beam” like approach, using a focused laser, is used to manipulate individual cells and colloidal particles. Funded in recent years by the NIH, NSF and NASA for microfluidic applications, our goal is the creation of technologically-relevant platforms including micron-scale colloidal-based devices as well as optical-based cell sorters and stretchers for bioanalysis and biomedical assay development.

近期论文

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66. K.B. Roth, K.B. Neeves, J. Squier, D.W.M. Marr, “Imaging of a Linear Diode Bar for an Optical Cell Stretcher”, Biomedical Optics Express, 2015, 6(3), Issue 3, 807-814. DOI:10.1364/BOE.6.000807 65. A. Kasukurti, C.D. Eggleton, S.A. Desai, D.I. Disharoon, D.W.M. Marr, “A Simple Microfluidic Dispenser for Single Microparticle and Cell Samples”, Lab on a Chip, 2014, 14 (24), 4673 - 4679. DOI:10.1039/c4lc00863d. 64. T. Sawetzki, C.D. Eggleton, S.A. Desai, D.W.M. Marr, “Dynamic Viscoelasticity as a Rapid Single-Cell Biomarker”, Biophysical Journal, 2013, 105(10), 2281-2288. DOI:10.1016/j.bpj.2013.10.003 K. Roth, C.D. Eggleton, K. Neeves, D.W.M. Marr, “Measuring Cell Mechanics by Optical Alignment Compression Cytometry”, Lab on a Chip, 2013, 13(8), 1517-1577. PMCID: PMC3623556, DOI: 10.1039/c31c41253a. M.W. Liberatore, D.W.M. Marr, A.M. Herring, J.D. Way. "Student created homework problems based on YouTube videos." Chemical Engineering Education. 47, 2013, 122-132. J. Squier, D.W.M. Marr, R. Applegate, T. Vestad, J. Chichester “Optical Based Cell Deformability”, Patent No. 8,119,976 2/21/2012. T. Sawetzki, C.D. Eggleton, D.W.M. Marr, “Cell Elongation via Intrinsic Antipodal Stretching Forces”, Physical Review E, 2012, 86, 061901. I. Sraj, A.C. Szatmary, S.A. Desai, D.W.M. Marr, C.D. Eggleton, “Erythrocyte Deformation in High-Throughput Optical Stretchers”, Physical Review E, 2012, 041923. (Also featured in the Virtual Journal of Nanoscale Science and Technology). A. Kasukurti, M. Potcoava, S.A. Desai, C.D. Eggleton, D.W.M. Marr, “Single Cell Isolation using a DVD Optical Pickup”, Optics Express, 2011, 19, 10377-10386. (Optics Express top-10 download for May, 2011. Also featured in the Virtual Journal of Biomedical Optics). D.W.M. Marr, T. Gong, D. Wu “Colloidal Crystallization via Applied Fields”, Patent No. 7,704,320 4/27/2010. I. Sraj, D.W.M. Marr, C.D. Eggleton, “Linear Diode Bar Optical Stretchers for Cell Deformation”, Biomedical Optics Express, 2010, 1, 482-488. I. Sraj, A.C. Szatmary, D.W.M. Marr, C.D. Eggleton, “Dynamic Ray Tracing for Modeling Optical Cell Manipulation”, Optics Express, 2010, 18, 16702-16714 .(Also featured in the Virtual Journal of Biomedical Optics). I. Sraj, C.D. Eggleton, R. Jimenez, E. Hoover, J. Squier, J. Chichester, D.W.M. Marr, “Cell Deformation Cytometry using Diode-Bar Optical Stretchers”, Journal of Biomedical Optics, 2010, 15, 047010. (Also featured in the Virtual Journal of Biological Physics Research). J. Oakey, D.W.M. Marr “Cell Sorting Device and Method of Manufacturing the Same”, Patent No. 7,472,794 1/6/2009. R.W. Applegate Jr., D.W.M. Marr, J. Squier, S. Graves, “Particle Size Limits when using Optical Trapping and Deflection of Particles for Sorting using Diode Laser Bars”, Optics Express, 2009, 17, 16731-16738. D. Schafer, M. Müller, M. Bonn, D.W.M. Marr, J. van Maarseveen, J. Squier, “CARS Microscopy for Quantitative Characterization of Mixing and Flow in Microfluidics”, Optics Letters, 2009, 34, 211-213. (Also featured in the Virtual Journal of Nanoscience and Technology and the Virtual Journal of Biomedical Optics). J. Oakey, D.W.M. Marr “Laminar Flow-Based Separations of Colloidal and Cellular Particles”, Patent No. 7,318,902 1/15/2008. T. Sawetzki, S. Rahmouni, C. Bechinger, D.W.M. Marr, “In-Situ Assembly of Linked Geometrically-Coupled Microdevices”, Proceedings of the National Academy of Sciences of the USA, 2008, 150, 20141-20145. R.W. Applegate Jr., J. Squier, T. Vestad, J. Oakey, D.W.M. Marr, “Fiber-Focused Diode-Bar Optical Trapping for Microfluidic Flow Manipulation”, Applied Physics Letters, 2008, 92, 013904 (Also featured in the Virtual Journal of Biological Physics Research the Virtual Journal of Nanoscience and Technology). J. Oakey, D.W.M. Marr “Laminar Flow-Based Separations of Colloidal and Cellular Particles”, Patent No. 7,276,170 10/2/2007.