个人简介

BS, Brigham Young University (1988) Ph.D., The University of Wisconsin (1993) Postdoctoral Research, Ohio State University (1993-1995) Awards: Brigham Young University Karl G. Maeser Research and Creative Arts Award, 2006 Stoel Rives Utah Innovation Award, Biotechnology, 2006 Brigham Young University Technology Transfer Award, 2005 Brigham Young University Karl G. Maeser Excellence in Teaching Award, 2004 Brigham Young University Creative Works Award, 2001 Brigham Young University Young Scholar Award, 2000 College of Physical and Mathematical Sciences Award for Excellence in Teaching, 1999 National Science Foundation CAREER Award, 1998 - 2002 Student Award for Excellence in Teaching-Department of Chemistry, 1998 Student Award for Excellence in Teaching-Department of Chemistry, 1997

研究领域

Organic Chemistry

Membrane active antibiotics Glycolipid immunology Our research is primarily in two areas. We have developed small-molecule mimics of antimicrobial peptides, and we are working to understand better their mechanism of antibacterial activity, optimize medical device coatings containing these mimics to prevent bacterial colonization, and optimizing compound structures for varied applications. We also work with immunostimulatory glycolipids and oligosaccharide vaccines.

近期论文

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Trainor, E. A.; Horton, K. E.; Savage, P. B.; Testerman, T. L.; McGee, D. J. Infect.. Immun. 2011, 79, 88-97. The role of the HefC efflux pump in Helicobacter pylori. cholesterol-dependent resistance to ceragenins and bile salts.. Braun, N. A.; Mendez-Fernandez, Y. V.; Covarrubias, R.; Porcelli, S. A.; Savage, P.. B.; Yagita, H.; Van Kaer, L.; Major, A. S. Arterialschlerosis Thrombosis Vasc. Biol. 2010,. 30, 1758-U178. Development of spontaneous anergy in invariant natural killer T cells in. a mouse model of dyslepidemia.. Epand, R. F.; Pollard, J. E.; Wright, J. O.; Savage, P. B.; Epand, R. M. Antimicrob.. Agents Chemother. 2010, 54, 3708-3717. Depolarization, bacterial membrane. composition and the antimicrobial action of ceragenins.. Smith, P. A.; Lepage, C. J.; Lukacs, M.; Martin, N.; Shufutinsky, A.; Savage, P.. B. Int. J. Mass Spectrosc.2010, 295, 113-118. Field-portable gas chromatography with. transmission quadrupole and cylindrical ion trap mass spectrometric detection:. chromatographic retention index data and ion/molecule interactions for chemical. warfare agent identification.. Semmling, V.; Lukacs-Kornek, V.; Thaiss, C. A.; Quast, T.; Hochheiser, K.; Panzer,. U.; Rossjohn, J.; Perlmutter, P.; Cao, J.; Godfrey, D. I.; Savage, P. B.; Knolle, P. A.;. Kolanus, W.; Förster, I., Kurts, C. Nature Immunol. 2010, 11, 313-U57. Alternative. cross-priming through CCL17/CCR4-mediated CTL attraction towards NKT cell-licensed. dendritic cells.. Bucki, R.; Leszczynska, K.; Byfield, F. J.; Fein, D. E.; Won, E.; Cruz, K.; Namiot, A.;. Kulakowska, A.; Namiot, Z.; Savage, P. B.; Diamond, S.; Janmey, P. A. Antimicrob.. Agents Chemother. 2010, 54, 2525-2533. Combined antibacterial and anti-. inflammatory activity in a cationic disubstituted dexamethasone spermine conjugate. (D2S).. Lee, H.-H.; Meyer, E. H.; Goya, S.; Pichavant, M.; Kim, H. Y.; Umetsu, S. E.;. Jones, J. C.; Savage, P. B.; Casasnovas, J. M.; Kaplan, G.; Freeman, G. J.; DeKruyff, R.. H.; Umetsu, D. T. J. Immunology 2010, 185, 522-5235. Apoptotic cells activate NKT. cells through Ig-like mucin-like-1 resulting in airway hyperreactivity.. Lara, D.; Feng, Y.; Bader, J.; Savage, P. B.; Maldonado, R. A. J. Parasitol. 2010,. 96, 638-642. Anti-trypanosomatid activity of ceragenins.. Monine, M. I.; Posner, R. G.; Savage, P. B.; Faeder, J. R.; Hlavacek, W. S. Biophys.. J. 2010, 95, 48-56. Modeling multivalent ligand-receptor interactions with steric. constraints on configurations of cell-surface receptor aggregates.. Freigang, S.; Zadorozhny, V.; McKinney, M.; Krebs, P.; Schrantz, N.; Masuda, K.;. Liu, Y.; Savage, P. B.; Bendelac, A.; Cravatt, B. F.; Teyton, L. J. Clin. Invest. 2010,. 120, 1873-1884. Fatty acid amide hydrolyase shapes NKT cell responses by regulating. the serum transport of lipid antigen.. Pollard, J.; Wright, J.; Feng, Y.; Geng, D.; Genberg, C.; Savage, P. B. Anti-. Infectives in Medicinal Chemistry2009, 8, 290-294. Activities of ceragenin CSA-13. against established biofilms in an in vitro model of catheter decolonization.. Leszczynska, K.; Namiot, A.; Fein, D. E.; Wen, Q.; Namiot, Z.; Savage, P. B.;. Diamond, S.; Janmey, P. A.; Bucki, R. Bactericidal activities of the cationic steroid CSA-. 13 and the cathelicidin peptide LL-37 against Helicobacter pylori in simulated gastric. juice. BMC Microbiol. 2009, 9, 187.. Morshed, S. R.; Takahashi, T.; Savage, P. B.; Kambham, N.; Strober, S. Clin.. Immunol. 2009, 132, 321-333. b-galactosylceramide alters invariant natural killer T cell. function and is effective treatment for lupus.. Howell, M. D.; Streib, J. E.; Kim B. E.; Lesley, L.; Dunlap, A.; Geng, D.; Savage, P.. B.; Leung, D. Y. M. J. Invest. Dermatol. 2009, 129, 2668-2675. Ceragenins: a new. class of anti-viral compounds to treat orthopox infections.. Yin, N.; Long, X.; Goff, R. D.; Zhou, D.; Cantu, C.; Mattner, J.; Saint Mezard, P.;. Teyton, L.; Bendelac, L.;Savage, P. B. ACS Chem. Biol. 2009, 4, 191-197. Alpha. anomers of iGb3 and Gb3 stimulate cyotkine production by natural killer T cells. PMCID:. PMC2843501. Kim, H. Y.; Pichavant, M.; Matangkasombut, P.; Koh, Y. I., Savage, P. B.; DeKruyff. R. H.; Umetsu, D. T. J. Immunol. 2009, 182, 3252-3261. The development of airway. hyperreactivity in T-bet-deficient mice requires CD1d-restricted NKT cells. Bai, L.; Sagiv, Y.; Liu Y.; Freigang, S.; Yu, K. A. O.; Teyton, L.; Porcelli, S.. A.; Savage, P. B.; Bendelac, A. Proc. Natl Acad. Sci. 2009, 106, 10254-10259.. Lysosomal recycling terminates CD1d-mediated presentation of short and. polyunsaturated variants of the NKT cell lipid antigen aGalCer.. Roohi, S.; Amir, N.; Ahmed, M.; Savage, P. B.; Saluhiddin, S. M.; Jehangir, M. J.. Radioanal. Nuclear Chem.2009, 97, 57-62. Synthesis, quality control and biological. evaluation of 99mTc labeled CSA-13.. Farruggia, G.; Iotti, S.; Prodi, L.; Zaccheroni, N.; Montalti, M.; Savage, P. B.;. Andreani, G.; Trapani, V.; Wolf, F. I. J. Fluorescence 2009, 19, 11-19. A simple. spectrofluoromethric assay to measure total intracellular magnesium by a. hydroxyquinoline derivative.. Isogai, E.; Isogai, H.; Takahashi, K.; Okumura, K.; Savage, P. B. Oral Microbiol.. Immunol. 2009, 24, 170-172. Ceragenin CSA13 exhibits antimicrobial activity against. cariogenic and periodontopathic bacteria.