Taghibiglou, Changiz - University of Saskatchewan

个人简介

Academic Credentials Pharm. D. (first grade with honors), College of Pharmacy, Tabriz University of Medical Sciences, Tabriz-Iran PhD, Department of Laboratory Medicine & Pathobiology (Clinical Biochemistry), University of Toronto, Canada Post-doctoral Research Neuroscience and Behavior Research Group, Hospital for Sick Children, University of Toronto, Canada Brain Research Centre and Department of Medicine, University of British Columbia, Vancouver, Canada Awards Brain Star Award winner 2009, Canadian Institutes of Health Research (CIHR) Canadian Institutes of Health Research (CIHR) fellowship (CAD $ 144,000) Michael Smith Foundation for Health Research fellowship (CAD$ 115,000)

研究领域

Excitotoxicity-induced neuronal apoptosis in stroke and neurodegenerative diseases Lipid rafts and neuronal receptor signaling and trafficking Lipid Neurobiology Brain insulin signaling pathways Designing bioactive short peptides

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Pham N, Sawyer TW, Wang Y, Rastgar Jazii F, Vair C, Taghibiglou C. Primary Blast-Induced Traumatic Brain Injury in Rats Leads to Increased Prion Protein in Plasma: A Potential Biomarker for Blast-Induced Traumatic Brain Injury. J Neurotrauma. 2014 Nov 4. [Epub ahead of print] Pham N, Dhar A, Khalaj S, Desai K, Taghibiglou C. Down regulation of brain cellular prion protein in an animal model of insulin resistance: possible implication in increased prevalence of stroke in pre-diabetics/diabetics. Biochem Biophys Res Commun. 2014 May 30;448(2):151-6. Stockwell J, Abdi N, Lu X, Maheshwari O, Taghibiglou C. Down regulation of brain cellular prion protein in an animal model of insulin resistance: possible implication in increased prevalence of stroke in pre-diabetics/diabetics. Chem Biol Drug Des. 2014 May;83(5):507-20. Cho T, Ryu JK, Taghibiglou C, Ge Y, Chan AW, Liu L, Lu J, McLarnon JG, Wang YT. Long-term potentiation promotes proliferation/survival and neuronal differentiation of neural stem/progenitor cells. PLoS One. 2013 Oct 17;8(10):e76860. Zhang S, Taghibiglou C, Girling K, Dong Z, Lin SZ, Lee W, Shyu WC, Wang YT. Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries. J Neurosci. 2013 May 1;33(18):7997-8008. Ahmad Nasrollahi S, Taghibiglou C, Fouladdel S, Dinarvand R, Moosavi Movahedi AA, Azizi E, Farboud ES. Physicochemical and biological characterization of pep-1/elastin complexes. Chem Biol Drug Des. 2013 Aug;82(2):189-95. Nasrollahi SA, Fouladdel S, Taghibiglou C, Azizi E, Farboud ES. A peptide carrier for the delivery of elastin into fibroblast cells. Int J Dermatol. 2012, 51(8):923-9. PMID:22788807 (a paper from my collaboration) Taghibiglou C (corresponding author), Mackenzie, I, Wang YT, and Cashman N. Sterol regulatory element binding protein-1 (SREBP-1) activation in motor neurons in excitoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide. Biochem. Biophys.Res. Comm. 2011, 413:159-63. PMID:21871872 Taghibiglou C, Henry G.S. Martin, Ted W. Lai, Taesup Cho, Shiv Prasad, Luba Kojic, Max Cynader and Yu Tian Wang. Role of NMDA receptor-dependent Activation of SREBP1 in neuronal excitotoxic and ischemic neuronal injuries. Nature Medicine, 2009, 15:1399-1406; PMID: 19966780 Taghibiglou C; Bradley C.A.;Gaertner T.; Li Y, Wang Y; and Wang YT. Mechanisms involved in cholesterol-induced neuronal insulin resistance.Neuropharmacology,2009, 57:268-76; PMID: 19523477 Taghibiglou C, Henry S. Martin, Jacqueline K. Rose, Wang YT, and Rankin C. Essential role of SBP-1 activation in oxygen deprivation induced lipid accumulation and increase in body width/length ratio in C. elegans. FEBS Letters, 2009, 583:831-4 ;PMID:19187779 Bradley CA, Taghibiglou C, Collingridge GL, and Wang YT. Mechanisms involved in the reduction of GABAA receptor alpha1 subunit expression caused by the epilepsy mutation A322D. Journal of Biological Chemistry,2008, 283:22043-50; PMID: 18534981 Stephane Peineau, Taghibiglou C (co-first author), Wang YT and Graham L Collingridge. LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β.Neuron, 2007, 53:703-717; PMID: 17329210 Meilke JG, Taghibiglou C, Wang YT. Endogenous Insulin Signaling Protects Cultured Neurons from Oxygen-Glucose Deprivation Induced Cell Death.Neuroscience. 2006, 143:165-73; PMID: 16978790 Mielke JG, Taghibiglou C, Liu L, Zhang Y, Jia Z, Adeli K, Wang YT. A Biochemical and Functional Characterisation of Diet-Induced Brain Insulin Resistance. Journal of Neurochemistry. 2005, 93:1568-1578; PMID: 15935073 Wang Y, Ju W, Fam S, D'Souza S, Taghibiglou C, Salter M, Wang YT. AMPA receptor endocytosis is essential for NMDA-induced neuronal apoptosis.Journal of Biological Chemistry. 2004, 279:41267-70; PMID: 15319422 Ahmadian G, Ju W, Liu L, Wyszynski M, Lee SH, Dunah AW, Taghibiglou C, Wang Y, Lu J, Wong TP, Sheng M, Wang YT. Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD. EMBO J. 2004, 23:1040-50; PMID: 14976558 Man HY, Wang Q, Lu WY, Ju W, Ahmadian G, Liu L, D'Souza S, Wong TP, Taghibiglou C, Lu J, Becker LE, Pei L, Liu F, Wymann MP, MacDonald JF, Wang YT. Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons. Neuron.2003, 38:611-24; PMID: 12765612 Wei Qiu, Changiz Taghibiglou, Rita Kohen Avramoglu, Stephen C. Van Iderstine, Mark Naples, Homa Ashrafpour, Shailen Mhapsekar, Ryuichiro Sato2and Khosrow Adeli . Oleate-Mediated Stimulation of Microsomal Triglyceride Transfer Protein (MTP) Gene Promoter: Implications for Hepatic MTP Overexpression in Insulin Resistance. Biochemistry. 2005, 44(8):3041-3049; PMID: 15723548 Taghibiglou C; Rashid-Kolvear F; Van Idersteine SC; Letien H; Fantus G; Lewis GF; and Adeli K. Hepatic VLDL-apoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphatase 1B in a fructose-fed hamster model of insulin resistance. Journal of Biological Chemistry. 2002, 277: 793-803; PMID: 11598116 Carpentier A, Taghibiglou C; Leung N, Szeto L, Van Idersteine SC; Uffelman K; Buckingham R; Adeli K, and Lewis GF. Ameliorated hepatic insulin resistance is associated with normalization of microsomal triglyceride transfer protein expression and reduction in VLDL assembly and secretion in the fructose-fed hamster. Journal of Biological Chemistry. 2002, 277: 28795-802; PMID: 12048212 Taghibiglou C; Van Idersteine SC; Kulinsky A; Ruddy D and Adeli K. Effect of Avasimibe a novel ACAT-inhibitor on the apoB biogenesis in hamster hepatocytes. Journal of Biochemical Pharmacology. 2002,63: 349-60.PMID: 11853686 Taghibiglou C; Carpentier A; Van Idersteine SC; Chen B; Ruddy D; Aiton A; Lewis GF; and Adeli K. Fructose-induced insulin resistance causes hepatic VLDL overproduction by facilitating lipoprotein assembly and reducing intracellular apoB degradation. Journal of Biological Chemistry. 2000, 275:8416-8425; PMID: 10722675 Taghibiglou C; Ruddy D; Van Idersteine SC; Aiton A; Cavallo D; Cheung R; and Adeli K. Intracellular mechanisms regulating apoB-containing lipoprotein assembly and secretion in primary hamster hepatocytes. Journal of Lipid Research. 2000, 41: 499-513; PMID: 10744770 Mangaloglu L; Cheung R; Van Iderstine S; Taghibiglou C; Pontrelli L; and Adeli K. Treatment with atorvastatin ameliorates VLDL overproduction in an animal model of insulin resistance, the fructose-fed Syrian golden hamster. Metabolism. 2002,51:409-418; PMID: 11912545