Jadhav, Ashok - University of Saskatchewan - Department of Pharmacology

个人简介

Academic Credentials: Licensed Veterinarian, SVMA and CVMA (Canada). PhD, Department of Physiology, University of Saskatchewan, 2009 MVSc, Bombay Veterinary College, Mumbai, India. 2004 BVSc & AH, Bombay Veterinary College, Mumbai, India. 2001 Teaching Interests: Experimental Pharmacology Laboratory General and Systemic Pharmacology Research Experience: Preclinical Pharmacological and Toxicological screening of New Chemical Entity (NCE) in Laboratory animals. Cardiovascular, Respiratory, Diabetes and Inflammation Research Research Positions: Research Associate: Department of Medicine, University of Saskatchewan, 2011-2012 Postdoctoral Fellow: Department of Pharmacology, University of Saskatchewan, 2009-2010 Graduate Research Assistant: Department of Physiology, University of Saskatchewan, 2006-2008. Senior Research Officer-II, Department of Pharmacology & Toxicology, Glenmark Research Centre, Glenmark Pharmaceutical Industry, India. 2005-2006. Research Officer-I, Department of Pharmacology & Toxicology, Glenmark Research Centre, Glenmark Pharmaceutical Industry, India. 2003-2004. Research Associate: Department of Veterinary Pathology, Bombay Veterinary College, Mumbai, India. 2003 (3 months).

研究领域

Cardiovascular Pharmacology Inflammation Hypertension Diabetes

近期论文

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Ndisang JF, Jadhav A, Mishra M. The heme oxygenase system suppresses perirenal visceral adiposity, abates renal inflammation and ameliorates diabetic nephropathy in Zucker diabetic fatty rats. PLoS One. 2014 Jan 30;9(1):e87936. Tiwari S, Mishra M, Jadhav A, Gerger C, Lee P, Weber L, Ndisang JF. The risk of heart failure and cardiometabolic complications in obesity may be masked by an apparent healthy status of normal blood glucose. Oxid Med Cell Longev. 2013;2013:253657. Salley TN, Mishra M, Tiwari S, Jadhav A, Ndisang JF. The heme oxygenase system rescues hepatic deterioration in the condition of obesity co-morbid with type-2 diabetes. PLoS One. 2013 Nov 15;8(11):e79270. Ndisang JF, Jadhav A. Hemin therapy improves kidney function in male streptozotocin-induced diabetic rats: role of the heme oxygenase/atrial natriuretic peptide/adiponectin axis. Endocrinology. 2014 Jan;155(1):215-29. Jadhav A, Gopalakrishnan V, Shoker A. Comparative in vitro effects of calcineurin inhibitors on functional vascular relaxations of both rat thoracic and abdominal aorta. Adv Pharmacol Sci. 2013;2013:718313. Ndisang JF, Jadhav A. Hemin therapy suppresses inflammation and retroperitoneal adipocyte hypertrophy to improve glucose metabolism in obese rats co-morbid with insulin-resistant type-2 diabetes. Diabetes Obes Metab. 2013 Nov;15(11):1029-39. Jadhav A., Liang W., Papageorgiou P., Shoker A., Kanthan S, Balsevich J.,Levy A., Heximer S, Backx P. H. and Gopalakrishnan V.. Catharanthine dilates small mesenteric arteries and decreases cardiac contractility by inhibition of L-type calcium channel currents. Accepted Jan, 2013: JPET/2012/199661 Jadhav A., Ndisang JF. Treatment with heme-arginate alleviates adipose tissue inflammation and improves insulin sensitivity and glucose metabolism in a rat model of human primary aldosteronism. Free Radic Biol Med 2012Oct 19, pii: S0891-5891(12)01760-1(Epub print) Mohamed A., Jadhav A, Hassan A. and Meng Q H., Acute Phase Reactants as Novel Predictors of Cardiovascular Disease," Mediators of Inflammation. SRN Inflammation Volume 2012 (2012), Article ID 953461, 18 pages. Jadhav A, Liang W, Balsevich J, Bastin G, Kroetsch J, Heximer S, Backx PH, Gopalakrishnan V. L-Tryptophan ethyl ester dilates small mesenteric arteries by inhibition of smooth muscle voltage-operated calcium channels. Br. J Pharmacol 2011 Sep 26. PMID: 21951131. Ndisang JF and Jadhav A. Heme arginate therapy enhanced adiponectin and atrial natriuretic peptide, but abated endothelin-1 with attenuation of kidney histopathological lesions in mineralocorticoid-induced hypertension, J Pharmacol Exp Ther. 2010 Jul;334(1):87-98. Ndisang JF, and Jadhav A, Heme-arginate suppresses phospholipase C and oxidative stress in the mesenteric arterioles of mineralocorticoid-induced hypertensive rats. Hypertens Res. 2010 Apr; 33(4):338-47. Ndisang JF, Lane N, Syed N, and Jadhav A., Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats. Endocrinology, 2010 Feb;151(2):549-60. Ndisang JF, and Jadhav A., The heme oxygenase system attenuates pancreatic lesions and improves insulin sensitivity and glucose metabolism in deoxycorticosterone acetate hypertension.Am J Physiol Regul Integr Comp Physiol. 2010 Jan;298(1):R211-23. Epub 2009 Oct 28. Ndisang JF, and Jadhav A., Upregulating the heme oxygenase system suppresses left ventricular hypertrophy in adult spontaneously hypertensive rats for 3 months. J Card Fail. 2009 Sep;15(7):616-28. Epub 2009 Apr 28. Jadhav A, and Ndisang JF., Heme arginate suppresses cardiac lesions and hypertrophy in deoxycorticosterone acetate-salt hypertension.. Exp Biol Med (Maywood). 2009 Jul;234(7):764-78. Epub 2009 May 8. Ndisang JF, and Jadhav A., Up-regulating the hemeoxygenase system enhances insulin sensitivity and improves glucose metabolism in insulin-resistant diabetes in Goto-Kakizaki rats. Endocrinology. 2009 Jun;150(6):2627-36. Epub 2009 Feb 19. Ndisang JF, Lane N, and Jadhav A., Upregulation of the heme oxygenase system ameliorates postprandial and fasting hyperglycemia in type 2 diabetes. Am J Physiol Endocrinol Metab. 2009 May;296(5):E1029-41. Epub 2009 Feb 10. Ndisang JF, and Jadhav A., Heme oxygenase system enhances insulin sensitivity and glucose metabolism in streptozotocin-induced diabetes. Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E829-41. Epub 2009 Feb 3. Jadhav A, Torlakovic E, and Ndisang JF., Hemin therapy attenuates kidney injury in deoxycorticosterone acetate-salt hypertensive rats. Am J Physiol Renal Physiol. 2009 Mar;296(3):F521-34. Epub 2008 Dec 30. Ndisang JF, Lane N, and Jadhav A., The heme oxygenase system abates hyperglycemia in Zucker diabetic fatty rats by potentiating insulin-sensitizing pathways.Endocrinology. 2009 May;150(5):2098-108. Epub 2008 Dec 23. Jadhav A, Torlakovic E, and Ndisang JF., Interaction among heme oxygenase, nuclear factor-kappaB, and transcription activating factors in cardiac hypertrophy in hypertension..Hypertension. 2008 Nov;52(5):910-7. Epub 2008 Sep 29. Ndisang JF, Lane N, and Jadhav A.,Crosstalk between the heme oxygenase system, aldosterone, and phospholipase C in hypertension.. J Hypertens. 2008Jun;26(6):1188-99. Ndisang JF, Lane N and Jadhav A. Interaction between the heme oxygenase system and aldosterone in hypertension, Int J Angiol 16:92-97, 2007. Mote C. S., Jadhav A. B., Nehete R. S., Suryawanshi D. S., Khadilkar M. V. and Lonkar P. S.; Correlation of circulating immune complexes (CIC) and immunoglobulin (Ig G) levels in different protocols in equines used for polyvalent antivenin production. The Journal of Bombay Veterinary College, an official organ of BVC alumni association. Vol: 12 (1&2) Pg. 49-52, 2004.