Lukong, Erique - University of Saskatchewan - Department of Biochemistry

个人简介

B.Sc., Keele University, UK, 1988, Department of Biochemistry, Biochemistry B.A., Keele University, UK, 1988, School of Humanities, French M.A. University of Montreal, 1992, Department of Linguistics, Translation M.Sc. University of Montreal, 1996, Department of Biochemistry, Biochemistry Ph.D., University of Montreal, 2002, Department of Biochemistry, Biochemistry Work in my lab is centered on breast tumor kinase (BRK) and two other BRK family members, FRK and SRMS. BRK is overexpressed in the majority of breast carcinomas, but the cellular and physiological implications of BRK overexpression, and the role played by the catalytic activity have not been fully defined. The current molecular classification of breast cancers includes the expression levels of receptors such as the ER, PR, and HER2. Preliminary data from our lab indicate that BRK activity is required for breast cancer tumor formation and metastasis. We intend to characterize BRK activity as a diagnostic and/or prognostic marker of breast cancer.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

S. Miah, A. Martin and K. E. Lukong. Constitutive activation of breast tumor kinase accelerates cell migration and tumor growth in vivo. Oncogenesis 2012. 1, e11 doi:10.1038/oncsis.2012.11 K.E. Lukong, M. E. Huot, and S. Richard. BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest. Cell Signal , 2009 Sep;21(9):1415-22 K.E. Lukong and S. Richard. Impaired motor coordination in mice deficient in the RNA-binding proteins Sam68. Behav Brain Res. 2008 June 3;189(2):357-63. K.E. Lukong and S. Richard. Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration. Cell Signal 2008;20(2):432-442.