Lee, Jeremy - University of Saskatchewan - Department of Biochemistry

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Ph.D, Cambridge University, Corpus Christi, 1977, Pharmacology B.A., Cambridge University, Corpus Christi, 1974, Chemistry D.Sc., University of Saskatchewan, 2007 The long term goal of my research program is to understand protein folding and misfolding and what factors influence these conformational changes. Nanopore analysis is an electrophoretic technique which can interrogate a single protein molecule as it interacts with a pore embedded in a membrane. The electronic signal is exquisitely sensitive to the conformation of the molecule and thus can provide structural information which would be difficult to obtain by conventional methods. Our work with misfolding proteins is leading to a better understanding of the biochemistry and pathology of neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Overall, this program will help to understand why proteins misfold and what might be done to prevent this. In the long term, this knowledge may lead to the development of drugs which could be used to treat neurodegenerative and other protein misfolding diseases. Jeremy Lee completed a PhD in pharmacology at Cambridge University and his thesis – “The Binding of Antibiotics to DNA" –marked the start of a life-long interest in the structure and function of nucleic acids. Lee’s initial research was analysis of monoclonal antibodies that bind to proteins, DNA or RNA, but it was the discovery of an unusual DNA structure in 1992, called M-DNA, that has dominated his research since. M-DNA has a metal ion in the middle of the DNA helix that causes the DNA to become a conductor of electrons rather than an insulator. It may be the smallest wire imaginable. Potential applications include M-DNA-based diagnostic tools that would quickly yield information on genetic disease and bacterial infection. Lee is proud of the fact that he has never taken a biochemistry course in his life, but has taught the subject for 25 years to undergraduates and medical and graduate students. His love of teaching is matched only by his hatred of PowerPoint, and he can frequently be seen walking around campus covered in chalk dust.

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Christopher Christensen, Christian Baran, Besnik Krasniqi, Radu I. Stefureac, Sergiy Nokhrin and Jeremy S. Lee, 2011. Effect of charge, topology and orientation of the electric field on the interaction of peptides with the α – hemolysin pore. J. Pept. Sci. 17:1-9 Radu I Stefureac, Dhruti Trivedi, Andre Marziali and Jeremy S. Lee, 2010. Evidence that small proteins translocate through silicon nitride pores in a folded confirmation. J. Phys. Condens. Matter 22, 454133-44 Christian Baran, Graham S.T. Smith, Vladimir V. Bamm, George Haruz, Jeremy S. Lee, 2010. Divalent cations induce a compaction of intrinsically disordered myelin basic protein. Biochem. Biophys. Res. Commun. 391, 224-229 Claudia Avis Madampage, Olga Andrievskaia, Jeremy S. Lee, 2010. Nanopore detection of antibody prion interactions. Anal. Biochem. 396, 36-41 Radu Stefureac and Jeremy S. Lee, 2008. Nanopore analysis of the folding of zinc fingers. Small 4,1646-1650