Verge, Valerie - University of Saskatchewan - Department of Anatomy and Cell Biology

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Ph.D. (1990) McGill University B.Sc. (1980) Concordia University Nerve Injury and Repair Mechanisms - Role of Neurotrophic Molecules Neurotrophic molecules are potent regulators of neuronal survival and differentiated phenotype. Current research is aimed at obtaining a greater understanding, at the cellular level, of the role of neurotrophic molecules and their receptors in the maintenance and repair of adult mammalian sensory neurons. The influence of neurotrophins (i.e. nerve growth factor, brain-derived neurotrophic factor or neurotrophin-3) on cytoskeletal, structural, growth/injury-associated and functional genes such as neuropeptides is assessed. Molecular biological, morphometric, histochemical and behavioural approaches are usedto determine the overall impact and therapeutic potential of these molecules.

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Verge VM, Andreassen CS, Arnason TG, Andersen H. Mechanisms of disease: role of neurotrophins in diabetes and diabetic neuropathy. Handb Clin Neurol. 2014;126:443-60. Ying Z, Misra V, Verge VM. Sensing nerve injury at the axonal ER: Activated Luman/CREB3 serves as a novel axonally synthesized retrograde regeneration signal. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16142-7. McLean NA, Popescu BF, Gordon T, Zochodne DW, Verge VM. Delayed nerve stimulation promotes axon-protective neurofilament phosphorylation, accelerates immune cell clearance and enhances remyelination in vivo in focally demyelinated nerves. PLoS One. 2014 Oct 13;9(10) Pettersson LM, Geremia NM, Ying Z, Verge VM. Injury-associated PACAP expression in rat sensory and motor neurons is induced by endogenous BDNF. PLoS One. 2014 Jun 26;9(6). Ying Z, Zhang R, Verge VM, Misra V. Cloning and Characterization of Rat Luman/CREB3, A Transcription Factor Highly Expressed in Nervous System Tissue. J Mol Neurosci. 2014 Jun 5. Nadeau JR, Wilson-Gerwing TD, Verge VM. Induction of a reactive state in perineuronal satellite glial cells akin to that produced by nerve injury is linked to the level of p75NTR expression in adult sensory neurons. Glia. 2014 May;62(5):763-77. Zhang R, Rapin N, Ying Z, Shklanka E, Bodnarchuk TW, Verge VM, Misra V. Zhangfei/CREB-ZF - a potential regulator of the unfolded protein response. PLoS One. 2013 Oct 14;8(10). Bray GE, Ying Z, Baillie LD, Zhai R, Mulligan SJ, Verge VM. Extracellular pH and neuronal depolarization serve as dynamic switches to rapidly mobilize trkA to the membrane of adult sensory neurons. J Neurosci. 2013 May 8;33(19):8202-15. Prosser-Loose EJ, Verge VM, Cayabyab FS, Paterson PG. Protein-energy Malnutrition Alters Hippocampal Plasticity-Associated Protein Expression Following Global Ischemia in the Gerbil. Curr Neurovasc Res. 2010 Oct 1. [Epub ahead of print] Gordon T, Udina E, Verge VM, de Chaves EI. Brief electrical stimulation accelerates axon regeneration in the peripheral nervous system and promotes sensory axon regeneration in the central nervous system. Motor Control. 2009 Oct;13(4):412-41. Review. Geremia NM, Pettersson LM, Hasmatali JC, Hryciw T, Danielsen N, Schreyer DJ, Verge VM. Endogenous BDNF regulates induction of intrinsic neuronal growth programs in injured sensory neurons. Exp Neurol. 2010 May;223(1):128-42. Epub 2009 Jul 28. Wilson-Gerwing TD, Johnston JM, Verge VM. p75 neurotrophin receptor is implicated in the ability of neurotrophin-3 to negatively modulate activated ERK1/2 signaling in TrkA-expressing adult sensory neurons. J Comp Neurol. 2009 Sep 1;516(1):49-58. Valderrama X, Rapin N, Verge VM, Misra V. Zhangfei induces the expression of the nerve growth factor receptor, trkA, in medulloblastoma cells and causes their differentiation or apoptosis. J Neurooncol. 2009 Jan;91(1):7-17. Epub 2008 Aug 22. Wilson-Gerwing TD, Stucky CL, McComb GW, Verge VM. Neurotrophin-3 significantly reduces sodium channel expression linked to neuropathic pain states. Exp Neurol. 2008 Oct;213(2):303-14. Epub 2008 Jun 14. Webber CA, Xu Y, Vanneste KJ, Martinez JA, Verge VM, Zochodne DW. Guiding adult Mammalian sensory axons during regeneration. J Neuropathol Exp Neurol. 2008 Mar;67(3):212-22. Geremia NM, Gordon T, Brushart TM, Al-Majed AA, Verge VM. Electrical stimulation promotes sensory neuron regeneration and growth-associated gene expression. Exp Neurol. 2007 Jun;205(2):347-59. Epub 2007 Feb 21. Wilson-Gerwing TD and Verge VMK (2006) Neurotrophin-3 attenuates galanin expression in the chronic constriction injury model of neuropathic pain. Neuroscience 141(4): 2075-85. Geremia NM Gordon T, Brushart T, A.A. Al-Majed AA and Verge VMK (2006) Brief electrical stimulation promotes sensory neuron regeneration of sensory neurons. In revision, J Exp Neurol. Brushart TM, Jari R, Verge V, Rohde C, Gordon T (2005) Electrical stimulation restores the specificity of sensory axon regeneration. Exp Neurol. 194(1):221-9. Wilson-Gerwing TD, Dmyterko M, Johnston JM, Zochodne DW, and Verge VMK (2005) Neurotrophin-3 prevents and reverses thermal hyperalgesia associated with neuropathic pain and attenuates TRPV1 (VR-1) expression in adult sensory neurons. J Neurosci 25(3):758-67. Li , XQ, Verge, VMK, Johnston, JM and Zochodne DW (2004) Unexpected CGRP peptide sequestration and expression within regenerating sensory axons and uninjured neighbour neurons. Journal Neuropathology and Experimental Neurology 63(10):1092-103. Pettersson, LME, Heine, T, Verge VMK, Sundler F and Danielsen N (2004) PACAP mRNA is expressed in rat spinal cord neurons. J Comp Neurol 471:85-96. Gratto KA and Verge VMK, 2003. Neurotrophin-3 downregulates trkA mRNA , NGF high-affinity binding sites and associated phenotype in adult DRG neurons. Eur J Neurosci, 18:1535 H. Jongsma Wallin, LME Pettersson, VMK Verge and N. Danielsen, 2003. Effect of anti-NGF treatment on PACAP expression in adult sensory neurons after adjuvant induced inflammation. Neuroscience 120(2): 325-31 D.W. Zochodne, V.M.K. Verge, C. Cheng, A. Hoke, C. Jolley, K. Thomsen, I. Rubin and M. Lauritzen, 2000. Nitric oxide synthase activity and expression in experimental diabetic neuropathy. J Neuropath Exp Neurol 59(9): 798-807.