Schreyer, David - University of Saskatchewan - Department of Anatomy and Cell Biology

研究领域

Research in Dr. Schreyer's lab examines the metabolic response that neurons undergo following injury, and how this response contributes to an ability to regenerate damaged nerve fibers. For example, GAP-43 is one of several proteins whose altered synthesis correlates with growth potential. Experimental work indicates that some aspect of the interaction of neurons with the target cells that they contact controls growth-associated gene expression. Tissue culture methods are being used to trace the steps in this signaling pathway. Protein biochemistry is being used to identify target-derived regulatory factors. Molecular biological approaches are being used to identify gene regulatory mechanisms. If these cell-cell signals and their pathways can be identified and artificially manipulated, it may be possible to induce normally recalcitrant neurons to undergo the required changes in gene expression, and to regenerate their damaged axons following CNS injury. Additional projects carried out in collaboration with the Tissue Engineering Research Group examine the feasibility of using artificial tissue scaffolds to facilitate regenerative repair of the damaged nervous system.

近期论文

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Zhai, P, Chen, XB, and Schreyer, DJ. (2015) In Vitro study of peptide-loaded alginate nanospheres for antagonizing the inhibitory effect of Nogo-A proteins on axon growth. Biomed. Mater. 10:05016 Rajaram, A., Schreyer, DJ, and Chen, XB. (2015) Use of the polycation polyethyleneimine to improve the physical properties of alginate-hyaluronic acid hydrogel during fabrication of tissue repair scaffolds. J. Biomater. Sci. Ploym. Ed. 26:433-445 Zhai, P., Chen, XB, Schreyer, DJ. (2015) PLGA/alginate composite microspheres for hydrophilic protein delivery. Mater. Sci. Eng. C. 56:251-259 Rajaram, A., Schreyer, DJ., Chen, XB. (2014) Bioplotting alginate/hyaluronic acid hydrogel scaffolds with structural integrity and preserved Schwann cell viability. 3D Printing and Additive Manufacturing 1:194-203 Smith, S.E., Figley, S.A., Schreyer, D.J., and Paterson P.G. (2014) Protein-energy malnutrition developing after global brain ischemia induces an atypical acute-phase response and hinders expression of GAP-43. PLoS One. 2014 Sep 26;9(9) Zha,i P., Chen, X.B., and Schreyer, D.J. (2013) Preparation and characterization of alginate microspheres for sustained protein delivery within tissue scaffolds. Biofabrication. 2013 Mar;5(1) Rajaram, A., Chen, X.B., and Schreyer, D.J. (2012) Strategic design and recent fabrication techniques for bioengineered tissue scaffolds to improve peripheral nerve regeneration. Tissue Eng Part B Rev. 2012 Dec;18(6):454-67. Li, M., Tian, X., Schreyer, D.J, and Chen, X. Effect of needle geometry on flow rate and cell damage in the dispensing-based biofabrication process. Biotechnol Prog. 2011 Nov-Dec;27(6):1777-84. Zhu, N., Chapman, D., Cooper, D., Schreyer, D.J., and Chen, X. X-ray diffraction enhanced imaging as a novel method to visualize low-density scaffolds in soft tissue engineering. Tissue Eng Part C Methods. 2011 Nov;17(11):1071-80. Wang, M., Zhai, P., Chen, X., Schreyer, D.J., Sun, X., and Cui, F. Bioengineered scaffolds for spinal cord repair. Tissue Eng Part B Rev. 2011 Jun;17(3):177-94. Zhu, N., Li, M.G., Guan, Y.J., Schreyer, D.J., and Chen, X.B. Effects of laminin blended with chitosan on axon guidance on patterned substrates. Biofabrication. 2010 Dec;2(4) Li, M., Tian, X., Zhu, N., Schreyer, D.J., and Chen, X. Modeling process-induced cell damage in the biodispensing process. Tissue Eng Part C Methods. 2010 Jun;16(3):533-42. Geremia, N.M., Pettersson, L.M.E., Hasmatali, J.C., Hryciw, T., Danielsen, N., Schreyer, D.J. and Verge, V.M.K. (2010) Endogenous BDNF regulates induction of intrinsic neuronal growth programs in injured sensory neurons. Exptl. Neurol. 223:128-142