Kulyk, William - University of Saskatchewan - Department of Anatomy and Cell Biology

个人简介

Research focuses on cell-matrix interactions and signal transduction processes regulating cartilage differentiation in the embryonic limb and craniofacial structures. Biochemical and molecular techniques are employed to identify intracellular and extracellular factors controlling cartilage-specific gene expression.

研究领域

Molecular regulation of embryonic cartilage and differentiation

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Little CJ, Kulyk WM, Chen X. The Effect of Chondroitin Sulphate and Hyaluronic Acid on Chondrocytes Cultured within a Fibrin-Alginate Hydrogel. J Funct Biomater. 2014 Sep 18;5(3):197-210. Izadifar Z, Chen X, Kulyk W. Strategic design and fabrication of engineered scaffolds for articular cartilage repair. J Funct Biomater. 2012 Nov 14;3(4):799-838. Xu Y, Wei K, Kulyk W, Gong SG. FLRT2 promotes cellular proliferation and inhibits cell adhesion during chondrogenesis. J Cell Biochem. 2011 Nov;112(11):3440-8. Smith TM, Wang X, Zhang W, Kulyk W, Nazarali AJ. Hoxa2 plays a direct role in murine palate development. Dev Dyn. 2009 Sep;238(9):2364-73. Bobick BE, Kulyk WM. Regulation of cartilage formation and maturation by mitogen-activated protein kinase signaling. Birth Defects Res C Embryo Today. 2008 Jun;84(2):131-54. Review. Wiens R, Rak M, Cox N, Abraham S, Juurlink BH, Kulyk WM, Gough KM. Synchrotron FTIR microspectroscopic analysis of the effects of anti-inflammatory therapeutics on wound healing in laminectomized rats. Anal Bioanal Chem. 2007 Mar;387(5):1679-89. Epub 2007 Jan 27. Bobick BE, Thornhill TM, Kulyk WM. Fibroblast growth factors 2, 4, and 8 exert both negative and positive effects on limb, frontonasal, and mandibular chondrogenesis via MEK-ERK activation. J Cell Physiol. 2007 Apr;211(1):233-43. Bobick, B.E. and W. M. Kulyk. (2006). MEK-ERK Signaling Plays Diverse Roles in the Regulation of Facial Chondrogenesis. Experimental Cell Research, April 15, 2006; 312(7):1079-1092. (journal Impact Factor = 4.15) Bobick, B.E. and W. M. Kulyk. (2004). The MEK-ERK Signaling Pathway Is a Negative Regulator of Cartilage-specific Gene Expression in Embryonic Limb Mesenchyme. Journal of Biological Chemistry, Feb 6, 2004; 279(6):4588-95. J.F. Wang, M.E. Olson, R.J. Winkfein , W.M. Kulyk, J.B. Wright, D.A. Hart, 2002. Molecular and cell biology of porcine HSP47 during wound healing: complete cDNA sequence and regulation of gene expression. Wound Repair and Regeneration, July 2002; 10(4):230-40. D.A. Hart, C. Reno, M.P. H. LeGraverand, L. Hoffman, and W.M. Kulyk, 2000. Expression of heat shock protein 47 (Hsp47) mRNA levels in rabbit connective tissues during the response to injury and in pregnancy. Biochemistry and Cell Biology 78(4):511-518. J.F. Wang, M.E. Olson, C.R. Reno, W.M. Kulyk, B.J. Wright, and D.A. Hart, 2000. Molecular and cell biology of skin wound healing in a pig model. Connective Tissue Research 41(3):195-211. W.M. Kulyk, J. L. Franklin, and L.M. Hoffman, 2000. Sox9 expression during chondrogenesis in micromass cultures of embryonic limb mesenchyme.Experimental Cell Research 255: 327-332. L.M. Hoffman and W.M. Kulyk, 1999. Alcohol promotes in vitro chondrogenesis in embryonic facial mesenchyme. International Journal of Developmental Biology, 43: 167-174. W.M. Kulyk and L.M. Hoffman, 1996. Ethanol exposure stimulates cartilage differentiation by embryonic limb mesenchyme cells. Experimental Cell Research223: 290-300. D.S. Pearson, W.M. Kulyk, G.M. Kelly, and P.H. Krone, 1996. Cloning and characterization of a cDNA encoding the collagen-binding stress protein hsp47 in zebrafish. DNA and Cell Biology, 15(3): 263-272.