研究领域

The research interests of the lab focus on deciphering at an atomic level the mechanism by which intracellular signals are transformed into structural changes in the cell/extracellular matrix adhesion receptors (Integrins) that mediate homeostasis and pathological processes of thrombosis, inflammation and cancer.

Nanotechnology, Mass Spectrometry

近期论文

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Haas, T.A., Plow, E.F.: The cytoplasmic domain of aIIbb3. A ternary complex of the integrin a and b subunits and a divalent cation. J.Biol.Chem. 271:6017-6026, 1996. Haas, T.A., Plow, E.F.: Development of a structural model of the cytoplasmic domain of an integrin. Protein Engineering 10:1395-1405, 1997. Huang, W., Haas, T.A., Biesterfeldt, J., Mankawsky, L., Koo, A., Blanton, R., Lee, X.: Purification and crystallization of a novel membrane anchored protein: the Schistosoma haematobium serpin. Acta Crystallographica D55:350-352, 1999. Haas, T.A., Vinogradova, O., Plow, E.F., Qin, J.: A structural basis for integrin activation by the cytoplasmic tail of the aIIb subunit. Proc.Natl,Acad.Sci. 97:1450-1455, 2000 Plow, E.F., Haas, T.A., Zhang, L., Loftus, J., Smith, J.W.: Ligand binding to integrins. J.Biol.Chem. 275:21785-21788, 2000. Plow, E.F., Cierniewski, C.S., Xiao, Z. Haas, T.A.: aIIbb3 and its antagonism at the new millennium. Thromb. Haemost. 86:34-40, 2001. Ruse, C.I., Kinter,M., Willard, B., Jin, J.P., Haas, T.A., Bond, M.: Quantitative dynamics of site-specific protein phosphorylation determined using liquid chromatography electrospray ionization mass spectrometry. Anal.Chem. 74: 1658-1664, 2002 Cierniewska-Cieslak, C., Cierniewski, C., Blecka, K., Papierak, M., Zhang, L., Haas, T.A., Plow, E.F.: Identification and characterization of two cation binding sites in the b3 integrin subunit. J.Biol.Chem. 277:11126-11134, 2002. Gudz, T.I., Schneider, T.E., Haas, T.A., Macklin, W.B.: Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes. J. Neurosci. 22:7398-407,2002. Vinogradova, O., Velyviene, A., Velyvis, A., Hu, B., Haas, T.A., Plow, E., Qin J.: A structural mechanism of integrin aIIbb3 "inside-out" activation as regulated by its cytoplasmic face. Cell 110:587-597, 2002. Xiong, Y.-M., Haas, T.A., Zhang, L: Identification of functional segments within the b2 I-domain of integrin aMb2. J.Biol.Chem. 277: 46639 - 46644, 2002. Ugarova, T.P., Lishko, V.K., Merulov, S.M., Yakubenko, V.P., Ryabokon, P.P., Yee, V.C., Haas, T.A.: Sequence _377-395 (P2), but not _190-202 (P1), is the binding site for the aM I-domain of integrin aMb2 in the C-domain of fibrinogen. Biochemistry, 42:9365-73, 2003. Vinogradova, O., Vaynberg, J., Kong, X., Haas, T.A., Plow, E.F., Qin, J. Membrane-mediated structural transitions at the cytoplasmic face during integrin activation. PNAS101: 4094-4099, 2004. Stefano, G., Renna, L., Chatre, L., Hanton, S., Haas, T.A., Brandizzi, F.: ARF3 plays a role in the binding of a GRIP domain of a peripheral matrix protein to the Golgi apparatus in plant cells. Plant J., 2006 Das U, Selvakumar P, Sharma RK, Haas TA, Dimmock JR. N-acyl-3,5-bis(arylidene)-4-piperidones and related compounds which stimulate fyn kinase. J Enzyme Inhib Med Chem. 2007 Aug;22(4):451-5. Haas, T.A. Allosteric regulation of αIIbβ3 by β3 95-105 (2008) Thrombosis and Haemostasis, 99 (4), pp. 701-710. Haas, T.A., Taherian, A., Berry, T., Ma, X. Identification of residues of functional importance within the central turn motifs present in the cytoplasmic tails of integrin αIIb and αV subunits (2008) Thrombosis Research, 122 (4), pp. 507-516. Haas, T.A. Discrete functional motifs reside within the cytoplasmic tail of αV integrin subunit (2008) Thrombosis and Haemostasis, 99 (1), pp. 96-107. Haas TA. vAllosteric regulation of alpha(IIb)beta(3) by beta(3) 95-105. Thromb Haemost. 2008 Apr;99(4):701-10. Taherian A, Li X, Liu Y, Haas TA. Differences in integrin expression and signaling within human breast cancer cells. BMC Cancer. 2011 Jul 13;11:293. Li X, Liu Y, Haas TA. Skelemin in integrin α(IIb)β(3) mediated cell spreading. Biochemistry. 2013 Jan 29;52(4):681-9. Li X, Liu Y, Haas TA. Peptides derived from central turn motifs within integrin αIIb and αV cytoplasmic tails inhibit integrin activation. Peptides. 2014 Dec;62:38-48