Eames, Brian - University of Saskatchewan - Department of Anatomy and Cell Biology

个人简介

The Eames lab uses molecular genetics and advanced imaging techniques to understand how skeletal tissues develop and evolve. A general focus of the lab is on skeletal cell differentiation. What are the external signals that direct undifferentiated cells to turn into bone or cartilage cells? How are these signals interpreted by cells to activate pathways of differentiation? On the one hand, the Eames lab is interested in applying answers to these questions to such debilitating diseases as osteoarthritis. On the other hand (and these hands know each other), the Eames lab is interested to know how these same answers vary among chordate clades. Since studying HIV during my undergrad, I became fascinated with understanding molecular mechanisms of evolution. In fact, I was accepted into grad school with the presumption that I would be a molecular virologist. But then I discovered the power of using embryonic development to study evolution. The skeletal system seemed fruitful to analyze. Ironically, my first job in science was getting stem cells to make bone in a dish, so after those intervening 5 years, I really came full circle. I figured that any genomic understanding of evolutionary changes to skeletal anatomy would require knowledge of the genes that drive cells to make skeletal tissues in the first place. On the practical side, I love the idea that my science can help people to live more active and healthy lives--my findings can be applied as therapies for bone fractures, osteoporosis, osteoarthritis, and many other serious contributors to inactivity in humans today. On the esoteric side, I love the idea that my work can serve as a textbook example of the genomics of trait evolution.

研究领域

Skeletal development and evolution molecular genetics synchrotron imaging 3D bioprinted tissue engineering Comparative transcriptomics

近期论文

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Hanwell, D, SA Hutchinson, C Collymore, AE Bruce, R Louis, A Ghalami, WT Allison, M Ekker, BF Eames, S Childs, DM Kurrasch, R Gerlai, T Thiele, I Scott, B Ciruna, JJ Dowling, S McFarlane, P Huang, XY Wen, MA Akimenko, AJ Waskiewicz, P Drapeau, LA Babiuk, D Dragon, A Smida, AG Buret, E O’Grady, J Wilson, L Sowden-Plunkett, V Tropepe (2016). Restrictions on the importation of zebrafish into Canada associated with spring viremia of carp virus. Zebrafish. PMID: 27248438. Olubamiji AD, Z Izadifar, J Si, DML Cooper, BF Eames, DXB Chen (2016). Modulating mechanical behavior of 3D-printed cartilage-mimetic PCL scaffolds: Influence of molecular weight and pore geometery. Biofabrication. Brown, DS, and BF Eames (2016). Emerging tools to study proteoglycan function during skeletal development. Methods in Cell Biology 134: 485-530. PMID: 27312503 Olubamiji AD, Z Izadifar, N Zhu, T Chang, DXB Chen, BF Eames (2016). Using synchrotron radiation inline phase-contrast imaging computed tomography to visualize three-dimensional printed hybrid constructs for cartilage tissue engineering. Journal of Synchrotron Radiation 23(3): 802-12. PMID: 27140161 Hackett MJ, GN George, IJ Pickering, BF Eames (2016). Chemical biology in the embryo: In situ imaging of sulfur biochemistry in normal and proteoglycan-deficient cartilage matrix. Biochemistry 55(17): 2441-51. [featured article “ACS Editors’ Choice”] PMID: 26985789. Izadifar, Z, T Chang, WM Kulyk, X Chen, BF Eames (2016). Analyzing biological performance of 3D-printed, cell-impregnated hybrid constructs for cartilage tissue engineering. Tissue Engineering Part C Methods 22(3): 173-88. [Cover image] PMID: 26592915. Edmunds, RC, B Su, JP Balhoff, BF Eames, WM Dahdul, H Lapp, JG Lundberg, TJ Vision, RA Dunham, PM Mabee, M Westerfield (2016). Phenoscape: Identifying candidate genes for evolutionary phenotypes. Molecular Biology and Evolution 33(1): 13-24. PMID: 26500251. Gomez-Picos, P, and BF Eames (2015). On the evolutionary relationship between chondrocytes and osteoblasts. Frontiers of Genetics 6: article 297; 1-15. PMID: 26442113. Yu, J, AH Jheon, EL Ealba, BF Eames, KD Butcher, SS Mak, R Ladher, T Alliston, RA Schneider (2014). Evolution of a developmental mechanism: Species-specific regulation of the cell cycle and the timing of events during craniofacial osteogenesis. Developmental Biology 385(2): 380-95. PMCID: 3953612 BF Eames, A DeLaurier, B Ullmann, TR Huycke, JT Nichols, J Dowd, M McFadden, MM Sasaki, and CB Kimmel (2013). FishFace: interactive atlas of zebrafish craniofacial development at cellular resolution. BMC Developmental Biology 13(1):23. PMCID: 3698193 Huycke, T, BF Eames, and CB Kimmel (2012). Hedgehog-dependent proliferation drives modular growth during morphogenesis of a dermal bone. Development 139: 2371-2380. PMCID:3367445 [featured article] Eames, BF, A Amores, YL Yan, and JH Postlethwait (2012). Evolution of the osteoblast: skeletogenesis in gar and zebrafish. BMC Evolutionary Biology 12:27. PMCID: 3314580 Eames, BF, YL Yan, ME Swartz, DS Levic, EM Knapik, JH Postlethwait, and CB Kimmel (2011). Mutations in fam20b and xylosyltransferase1 reveal that cartilage matrix controls timing of endochondral ossification through inhibition of chondrocyte maturation. PLoS Genetics 7(8): e1002246. PMCID: 3161922 Solem, RC, BF Eames, M Tokita, and RA Schneider (2011). Mesenchymal and mechanical mechanisms of secondary cartilage induction. Developmental Biology 356(1): 28-39. PMCID: 3130809 DeLaurier, A, BF Eames, B Blanco-Sanchez, G Peng, X He, ME Swartz, B Ullmann, M Westerfield, and CB Kimmel (2010). Zebrafish sp7-EGFP: a transgenic for studying otic vesicle formation, skeletogenesis, and bone regeneration. Genesis 48(8): 505-11. PMCID: 2926247 Eames, BF*, A Singer*, GA Smith*, ZA Wood, YL Yan, X He, J Polizzi, JM Catchen, A Rodriguez-Mari, T Linbo, DW Raible, JH Postlethwait (2010). Uxs1 is required for proper morphogenesis and histogenesis of the craniofacial skeleton. Developmental Biology 341(2): 400-15. PMCID: 2888048 Zhang, G, BF Eames, and MJ Cohn (2009). Evolution of vertebrate cartilage development. In: Current Topics in Developmental Biology, Vol. 86, William R. Jeffrey, editor, pp 15-42. Burlington: Academic Press. PMID: 19361688 Eames, BF, and RA Schneider (2008). The genesis of cartilage size and shape during development and evolution. Development 135: 3947-58. PMCID: 2836324 Merrill, AE, BF Eames, SJ Weston, T Heath, and RA Schneider (2008). Mesenchyme-dependent BMP signaling directs the timing of mandibular osteogenesis. Development 135(7): 1223-34. [Selected by Faculty of 1000 as a "Must Read" F1000 Factor 6.0]. PMCID: 2844338 Eames, BF, NC Allen, J Young, AJ Kaplan, JA Helms, and RA Schneider (2007). Skeletogenesis in the swell shark Cephaloscyllium ventriosum. J Anatomy 210(5): 542-54. [Cover image] PMCID: 2375745 Miller, MR, TS Atwood, BF Eames, JK Eberhart, YL Yan, JH Postlethwait, and EA Johnson (2007). RAD marker microarrays enable rapid mapping of zebrafish mutations. Genome Biology 8(6): R105. PMCID: 2394753 Eames, BF, and RA Schneider (2005). Quail-duck chimeras reveal spatiotemporal plasticity in molecular and histogenic programs of cranial feather development. Development 132(7): 1499-1509. [Featured article, "Creating Birds of a Feather" in Science STKE, 22 March 2005 (276:108); Selected by Faculty of 1000 as a "Must Read" F1000 Factor 6.0]. PMCID: 2835538 Miclau T, RA Schneider, BF Eames, and JA Helms (2005). Common molecular mechanisms regulating fetal bone formation and adult fracture repair. In: Bone Regeneration and Repair: Biology and Clinical Applications. J. R. Lieberman and G. E. Friedlaender. Totowa, NJ, Humana Press, Inc.: 45-55. Eames, BF, PT Sharpe, and JA Helms (2004). Hierarchy revealed in the specification of three skeletal fates by Sox9 and Runx2. Developmental Biology 274(1): 188-200. PMID: 15355797 Eames, BF, and JA Helms (2004). Conserved molecular program regulating cranial and appendicular skeletogenesis. Developmental Dynamics 231(1): 4-13. PMID: 15305282