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个人简介

Education BSc Biochemistry, University of Victoria PhD Biochemistry, University of Alberta Research post-doctoral fellowship Universitat Munchen, Germany Research post-doctoral fellowship University of Alberta MD, University of Alberta Clinical post-doctoral fellowship (Adult Endocrinology) University of Alberta Faculty Appointments Associate Professor and Clinician Scientist, Department and College of Medicine Associate member in Department of Anatomy and Cell Biology Member in the College of Graduate Studies Member of the Drug Discovery and Development Research Group, U of S Assistant Program Director for Research for the Internal Medicine Residency Program Chair for the Endocrine Module, undergraduate medical education year 2 Awards and Scholarships 2015 SHRF Top Research Team award for the Collaborative Innovation Development Grant, Biomedical. Alberta Heritage Foundation for Medical Research (AHFMR) Scholarship for PhD studies, University of Alberta Alexander von Humboldt Fellowship, European Molecular Biological Organization Fellowship (EMBO), Universitat Munchen Human Frontiers International Science Program Fellowship (HFISPF), Universitat Munchen Nominated (but didn’t win!) for the Teaching Excellence Award, College of Medicine, University of Saskatchewan

近期论文

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Arnason T, Harkness T. Development, Maintenance, and Reversal of Multiple Drug Resistance: At the Crossroads of TFPI1, ABC Transporters, and HIF1alpha. Cancers special edition: Drug/radiation resistance in cancer therapy. 2015 Jul;7(1):2063-2082. Epub 2015 Jul. Gorka J, Taylor-Gjevre R, Arnason T. Clinical and metabolic consequences of hyperthyroidism on bone density. International Journal of Endocrinology. (Special Edition on Osteoporosis). 2013:1-11. Epub 2013 Jun.http://dx.doi.org/10.1155/2013/638727. Malo M, Postnikoff S, Arnason T, Harkness T. Mitotic degradation of yeast Fkh1 by the Anaphase Promoting Complex is required for normal longevity, genomic stability and stress resistance. Aging Journal. 2016 Apr. Epub 2016 Apr. Jaio R, Postnikoff S, Harkness T, Arnason T. The SNF1 kinase UBA domain restrains its activation, activity, and the yeast lifespan. Journal of Biological Chemistry. 2015(6). Epub 2015 Apr. Comment: Jaio is my PhD student. Selected as highlight paper of the week. Gavidel A, Baxi K, Prusinkiewicz M, Ignatchenko V, Arnason T, Kislinger T, Carvalho C, Harkness T. A Genome Scale Screen for Mutants with Delayed Exit from Mitosis: Ire1-independent Induction of Autophagy Integrates ER Homeostasis into Mitotic Lifespan. PLOS Genetics. 2015 Aug;11(8). Epub 2015. Michel D, Gaunt M, Arnason T, El-Aneed A. Development and validation of fast and simple flow injection analysis-tandem mass spectrometry (FIAMS/ MS) for the determination of metformin in dog serum. Journal of Pharmaceutical and Biomedical Analysis. 2014 Dec:107C:229-235. Epub 2014 Dec 17. Harkness T, Arnason T. A Simplified Method for Measuring Secreted Invertase Activity in Saccharomyces cerevisiae. Biochemistry & Pharmacology: Open Access. 2014;3(6):151-56. Epub 2014 Oct. doi:10.4172/2167-0501.1000151 Davies G, Berg A, Postnikoff S, Wilson H, Arnason T, Kusalik A, Harkness T. TFPI1 mediates resistance to Doxorubicin in breast cancer cells by inducing a hypoxic-like response. PLoS One. 2014 Jan. Epub 2014 Jan 28. DOI: 10.1371/journal.pone.0084611. Menzel J, Malo M, Chan C, Prusinkiewicz M, Arnason T, Harkness T. The anaphase promoting complex regulates yeast lifespan and rDNA stability by targeting Fob1 for degradation. Genetics. 2014 Mar;196(3):693- 709. Epub 2013 Dec. doi:10.1534/genetics.113.158949. Epub 2013 Dec 20. Comment: Highlight article of the month for March, 2014. Salbu H, Arnason T. Pituitary granulomatosis with polyangiitis. British Medical Journal Case Reports. 2013. doi:10.1136/bcr-2013-008656. Aboulhosn K, Arnason T. Acute pancreatitis and severe hypertriglyceridemia masking unsuspected underlying diabetic ketoacidosis. British Medical Journal Case Reports. 2013. Epub 2013. doi:10.1136/bcr-2013- 200431. Sehmer B, Arnason T. Pop provoked paralysis: Silent Graves' disease presenting as thyrotoxic periodic paralysis. British Medical Journal Case Reports. 2012. Epub 2013 Nov. bcr2012006292. doi: 10.1136/bcr- 2012-006292. Mansell D, Blackburn D, Arnold T, Arnason T. Pre-CFL: Prevalence of cardiometabolic risk factors in college football linemen. Canadian Journal of Diabetes. 2011;35(5):497-502. Slabu H, Sevedia-Cayabyab S, Senior P, Arnason T. Permanent hemichorea associated with transient hyperglycemia. British Medical Journal Case Reports. 2011. doi:10.1136/bcr.08.2011.4641. Turner E, Malo M, Pisclevich M, Dash M, Davies D, Arnason T, Harness T. The Saccharomyces cerevisiae anaphase-promoting complex interacts with multiple histone-modifying enzymes to regulate cell cycle progression. Eukaryotic Cell. 2010;9(10):1418. Davies G, Arnason TG, Ross A, Juurlick B, Harkness TAA. Novel inhibition of histone deacetylase activity by troglitazone in cancer cells. Cancer Letters. 2010;288(2):236-250.

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