研究领域
Physiological and moelcualr mechanisms of uptake, metabolism and toxicity of metals/metal-mixtures in aquatic animals
Development and validation of approaches/tools for risk assessments of metals in the aquatic ecosystems
Assessment of population level effects of industrial metal pollution in the Canadian sub-Arctic and high Arctic
The overall objective of my research program is to study the fundamental molecular and physiological mechanisms by which aquatic animals, primarily fish, take up and handle essential and non-essential trace metals from the environment. Anthropogenic activity has led to elevated concentrations of trace metals in many natural waters with adverse consequences for aquatic life. A comprehensive understanding of the physiology of metal uptake, homeostasis, toxicity and interplay with other environmental factors is required to develop approaches/tools for risk assessments of metals in the aquatic ecosystems. With that in mind, my goal is to investigate the complex relationships among water and food quality, metal speciation, uptake, metabolism, accumulation and toxicity in metal-exposed animals. While the starting point is always basic mechanistic physiology, my research uses tools of organismic physiology, biochemistry, cell and molecular biology, geochemistry, and modeling to address these issues.
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M.K. Driessnack, A. Jamwal, S. Niyogi. 2017. Effects of chronic waterborne cadmium and zinc interactions on tissue-specific metal accumulation and reproduction in fathead minnow (Pimephales promelas). Ecotoxicology and Environmental Safety, 140, 65-75.
S. Niyogi, T.A. Blewett, T. Gallagher, S. Fehsenfeld, C.M. Wood. 2016. Effects of salinity on short-term zinc uptake, accumulation and sub-lethal toxicity in the green shore crab (Carcinus maenas). Aquatic Toxicology 178, 132-140.
C.N. Glover, S. Niyogi, T.A. Blewett, C.M. Wood. 2016. Iron transport across the skin and gut epithelia of Pacific Hagfish: Kinetic characterization and effect of hypoxia. Comparative Biochemistry and Physiology Part A, 199, 1-7.
S. Amuno, S. Niyogi, M. Amuno, J. Attitaq. 2016. Heavy metal accumulation and histopathological alterations in wild arctic hares (Lepus arcticus) inhabiting a former lead-zinc mine in the Canadian High Arctic: A preliminary study. Science of the Total Environment 556, 252-263.
M.K. Driessnack, A.L. Matthews, J.C. Raine, S. Niyogi. 2016. Interactive effects of chronic waterborne copper and cadmium exposure on tissue-specific metal accumulation and reproduction in fathead minnow (Pimephales promelas). Comparative Biochemistry and Physiology Part C 179, 165-173.
M. Naderi, A. Jamwal, D. Chivers, S. Niyogi. 2016. Modulatory effests of dopamine receptors on associative learning performance in zebrafish (Danio rerio). Behavioural Brain Research 303, 109-119.
M. Naderi, A. Jamwal, M. Ferrari, S. Niyogi, D. Chivers. 2016. Dopamine receptors participate in the acquisition and consolidation of latent learning of spatial information in zebrafish (Danio rerio). Progress in Neuro-Psychopharmacology & Biological Psychiatry 67, 21-30.
A. Jamwal, M. Naderi, S. Niyogi. 2016. An in vitro examination of selenium-cadmium antagonism using primary cultures of rainbow trout (Oncorhynchus mykiss) hepatocytes. Metallomics 8, 218-227.
S. Niyogi, S.R. Nadella, C.M. Wood. 2015. Interactive effects of waterborne metals in binary mixtures on short-term gill-metal binding and ion uptake in rainbow trout (Oncorhynchus mykiss). Aquatic Toxicology 165, 109-119.
T.A. Blewett, C.N. Glover, S. Fehsenfeld, M.J. Lawrence, S. Niyogi, G.G. Goss, C.M. Wood. 2015. Making sense of nickel accumulation and sub-lethal toxic effects in saline waters: Fate and effects of nickel in the green crab, Carcinus maenas. Aquatic Toxicology 164, 23-33.
A. Manek, M. Ferrari, D. Chivers, S. Niyogi. 2014. Dissolved organic carbon ameliorates the effects of UV radiation on a freshwater fish. Science of the Total Environment 490, 941-946.
Y. Wang, M. Ferrari, Z. Hoover, A. Yousafzai, D. Chivers, S. Niyogi. 2014. The effects of chronic exposure to environmentally relevant levels of waterborne cadmium on reproductive capacity and behaviour in fathead minnows. Archives of Environmental Contamination and Toxicology 67, 181-191.
S. Niyogi, K.V. Brix, M. Grosell. 2014. Effects of chronic waterborne nickel exposure on growth, ion homeostasis, acid-base balance, and nickel uptake in the freshwater pulmonate snail, Lymnaea stagnalis. Aquatic Toxicology 150, 36-44.
B.D. Hall, J.L. Doucette, L.M. Bates, A. Bugajski, S. Niyogi, C.M. Somers. 2014. Differential trends in mercury concentrations in Double-Crested Cormorant populations of the Canadian Prairies. Ecotoxicology 23, 419-428.
A. Manek, M. Ferrari, S. Niyogi, D.P. Chivers. 2014. The interactive effects of multiple stressors on physiological stress responses and club cell investment in fathead minnows. Science of the Total Environment 476-477, 90-97.
P. Chakbaborty, A.K. Manek, S. Niyogi, J. Hudson. 2014. Determination of dynamic metal complexes and their diffusion coefficients in the presence of different humic substances by combining two analytical techniques. Analytical Letters 47, 1224-1241.
J.D. Ouellet, M.G. Dube, S. Niyogi. 2013. The influence of elevated alkalinity and natural organic matter (NOM) on tissue-specific metal accumulation and reproductive performance in fathead minnows during chronic, multi-trophic exposures to a metal mine effluent. Ecotoxicology and Environmental Safety 95, 104-112.
J.D. Ouellet, M.G. Dube, S. Niyogi. 2013. The influence of food quantity on metal bioaccumulation and reproduction in fathead minnows (Pimephales promelas) during chronic exposures to a metal mine effluent. Ecotoxicology and Environmental Safety 91, 188-197.
J.D. Ouellet, M.G. Dube, S. Niyogi. 2013. A single metal, metal mixture, and whole-effluent approach to investigate causes of metal mine effluent effects on fathead minnows (Pimephales promelas). Water, Air, & Soil Pollution 224(3), 1-19.
R.W. Kwong, C. Hamilton, S. Niyogi. 2013. Effects of elevated dietary iron on the gastrointestinal expression of Nramp genes and iron homeostasis in rainbow trout (Oncorhynchus mykiss). Fish Physiology and Biochemistry 39, 363-372.
S. Misra, R.W. Kwong, S. Niyogi. 2012. Transport of selenium across the plasma membrane of primary hepatocytes and enterocytes of rainbow trout. Journal of Experimental Biology 215, 1491-1501.
S. Misra, C. Hamilton, S. Niyogi. 2012. Induction of oxidative stress by selenomethionine in isolated hepatocytes of rainbow trout (Oncorhynchus mykiss). Toxicology in Vitro 26, 621-629.
S. Misra, D. Peak, N. Chen, C. Hamilton, S. Niyogi. 2012. Tissue-specific accumulation and speciation of selenium in rainbow trout (Oncorhynchus mykiss) exposed to elevated dietary selenomethionine. Comparative Biochemistry and Physiology Part C 155, 560-565.
A. Manek, M.C. Ferrari, J.M. Sereda, S. Niyogi, D.P. Chivers. 2012. The effects of UV radiation on a freshwater prey fish: physiological stress response, club cell investment and alarm cue production. Biological Journal of the Linnean Society 105, 832-841.
R.W. Kwong, S. Niyogi. 2012. Cadmium transport in isolated enterocytes of freshwater rainbow trout: interactions with zinc and iron, effects of complexation with cysteine, and an ATPase-coupled efflux. Comparative Biochemistry and Physiology Part C 155, 238-246.