个人简介

I am a geneticist by training. My research revolves around germ cell biology. In the lab, we use the nematode C.elegans as a research model system to understand the role of oocytes in aging, epigenetics and embryonic development.

研究领域

Germ cell Aging C. elegans Genetics Epigenetics

The formation of viable gametes represents the first step towards the generation of a new organism. To ensure genome integrity and fertilizability, germ cells have to undergo dramatic remodeling of their genome and cytoplasm. With an older population and increasing maternal and paternal ages, Canadians are experiencing a dramatic rise in the frequency of miscarriages and genetic disorders, such as trisomies. Despite the well-established links between meiotic progression and chromosome abnormalities, the exact faulty mechanisms behind the deterioration in oocyte/sperm quality are not well understood at the molecular level. My laboratory utilizes C. elegans, a 1mm transparent worm, to study different aspects of germ cell differentiation. C. elegans has recently been shown to provide a reliable model system to study the process of reproductive aging in humans, demonstrating the applicability of this organism to model important aspects of human biology.

近期论文

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(1) A. Ghavidel, K. Baxi, V. Ignatchenko, M. Prusinkiewicz, T.G. Arnason, T. Kislinger, C.E. Carvalho and T. Harkness. 2015. A genome scale screen for mutants with delayed exit from mitosis: Ire1-independent induction of autophagy integrates ER homeostasis into mitotic lifespan. PLoS Genetics 11: e1005429. (2) Y.B. Tzur, C.E. de Carvalho, I. Van Bostelen, Y. Gu, I.M. Cheeseman and M.P. Colaiacovo. 2012. LAB-1 restricts Aurora-B kinase upon entrance into meiosis to promote the establishment and maintenance of sister chromatid cohesion. PLoS Biology 10.1371/journal.phbio.1001378. (3) N.Habibi-Babadi, A. Su, C.E. de Carvalho, A. Colavita. (2010). The N-glycanase png-1 acts cell non-autonomously to limit axon branching during organ formation in C. elegans. J. Neurosciences 30: 1766-1776. (4) C.E. de Carvalho, S. Zaaijer, Y. Gu, J.M. Schumacher, S. Smolokov, and M.P. Colaiacovo. (2008). LAB-1 antagonizes the Aurora B kinase in C. elegans. Genes Dev. 22: 2869-2885. (Cover article (5) D.F. Kelleher, C.E. de Carvalho, A.V. Doty, M. Layton, A.T. Cheng, L.D. Mathies, D. Pilgrim, E.S. Haag. (2008). Comparative genetics of sex determination: masculinizing mutations in Caenorhabditis elegans. Genetics 178: 1415-1429. (6) C.E. de Carvalho and M.P. Colaiacovo. (2006). SUMO-mediated regulation of synaptonemal complex formation during meiosis. Genes Dev. 20: 1986-1992. (7) R.C. Hill, C. E. de Carvalho, J. Salogiannis, B. Schlager, D. Pilgrim and E.S. Haag. (2006). Genetic Flexibility in the Convergent Evolution of Hermaphroditism. Dev. Cell 10: 531-538.