个人简介

BS, Brigham Young University (1995) Ph.D., The Scripps Research Institute (2000) NIH Postdoctoral Fellow, UC Irvine (2000-2002) AWARDS AND HONORS 2012 Long-Term Invitation Fellowship, Japan Society for the Promotion of Science 2011 College High-Impact Research Program Award, Brigham Young University 2009 #1 Most-Accessed Article, J. Am. Chem. Soc., April–June 2009 2008 Top-50 Most Cited Article Award, Tetrahedron 2005–2008 2006 Invited Participant, ACS Organic Division Young Investigators Symposium 2004 Research Innovation Award, Research Corporation 2004 Student Honor Association Award, Brigham Young University 2000–2002 National Institutes of Health Postdoctoral Fellowship 1995–1998 National Science Foundation Graduate Research Fellowship 1989–1990, 1992–1995 BYU Trustees Scholarship 1995 Honorable Mention, USA Today Academic All-American 1995 BYU Outstanding Senior in Chemistry

研究领域

Organic Chemistry

Our research is focused on the total synthesis of architecturally complex, biologically active natural products. We believe that the structures of such compounds can serve as inspiration for the invention of new organic reactions and processes. Thus, we carefully select our synthetic targets with the development of novel and useful chemistry as a main objective. We also engage in chemical biology studies to determine the pharmacophore and/or mode of action of the targets. Some natural products of current or recent interest are shown below.

近期论文

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Ma, Z.; Jiang, J.; Luo, S.; Cai, Y.; Cardon, J. M.; Kay, B. M.; Ess, D. H.;* Castle, S. L.* “Selective Access to E- and Z-Ile-Containing Peptides via a Stereospecific E2 Dehydration and an O N Acyl Transfer.” Org. Lett. 2014, 16, 4044–4047. Castle, S. L.* “Total Synthesis of the Congested Propellane Alkaloid (–)-Acutumine.” Chem. Rec. 2014, 14, 580–591. Wu, J.; Ma, B.;* Wang, Y.; Zhang, Y.; Yan, S.; Castle, S. L. “Lewis Acid Facilitated Regioselective Synthesis of -Histidinoalanine.” Tetrahedron Lett. 2014, 55, 3114–3116. Loertscher, B. M.; Zhang, Y., Castle, S. L.* “Exploration of an Epoxidation–Ring-Opening Strategy for the Synthesis of Lyconadin A and Discovery of an Unexpected Payne Rearrangement.” Beilstein J. Org. Chem. 2013, 9, 1179–1184. Loertscher, B. M.; Young, P. R.; Evans, P. R.; Castle, S. L.* “Diastereoselective Synthesis of Vicinal Tertiary Diols.” Org. Lett. 2013, 15, 1930– 1933. Castle, S. L.;* Ma, B. “Total Synthesis of the Unusual Peptide Celogentin C” In Strategies and Tactics in Organic Synthesis; Harmata, M., Ed.; Academic Press: UK, 2013; Vol. 9, pp 45– 77. Loertscher, B. M.; Castle, S. L.* “Radical Cyclizations and Sequential Radical Reactions.” In Comprehensive Organic Synthesis II; Knochel, P. and Molander, G. A., Eds.; Elsevier: In Press; Vol. 4 (Ma, S. and Zhang, J., Vol. Eds.). Quast, A. D.; Wilde, N. C.; Matthews, S. S.; Maughan, S. T.; Castle, S. L.; Patterson, J. E.* “Improved Assignment of Vibrational Modes in Sum-Frequency Spectra in the C–H Stretch Region for Surface-Bound C18 Alkylsilanes.” Vib. Spectrosc. 2012, 61, 17–24. Ma, Z.; Naylor, B. C.; Loertscher, B. M.; Hafen, D. D.; Li, J. M.; Castle, S. L.* “Regioselective Base-Free Intermolecular Aminohydroxylations of Hindered and Functionalized Alkenes.” J. Org. Chem. 2012, 77, 1208–1214. Castle, S. L.* “Six-Membered Hetarenes with More Than Three Heteroatoms.” In Science of Synthesis Knowledge Updates 2011/4; Weinreb, S. M., Ed.; Thieme: Stuttgart, 2012; Vol. 2011/4, Section 17.3.4, pp 345–375. Johnson, A. G.; Loertscher, B. M.; Moeck, A. R.; Matthews, S. S.; Ess, D. H.;* Castle, S. L.* “Experimental and Theoretical Investigation of the Scope of Enantioselective Ketone Allylations Employing Nakamura’s Allylzinc–Bisoxazoline Reagent.” Bioorg. Med. Chem. Lett. 2011, 21, 2706–2710. Loertscher, B. M.; Castle, S. L.* “Back to Basics.” Nature Chem. 2010, 2, 807–808 (invited News & Views article). Banerjee, B.; Litvinov, D. N.; Kang, J.; Bettale, J. D.; Castle, S. L.* “Stereoselective Additions of Thiyl Radicals to Terminal Ynamides.” Org. Lett. 2010, 12, 2650–2652. Ma, B.; Banerjee, B.; Litvinov, D. N.; He, L.; Castle, S. L.* “Total Synthesis of the Antimitotic Bicyclic Peptide Celogentin C.” J. Am. Chem. Soc. 2010, 132, 1159–1171. Li, F.; Tartakoff, S. S.; Castle, S. L.* “Enantioselective Total Synthesis of (–)-Acutumine.” J. Org. Chem. 2009, 74, 9082–9093. Ma, B.; Litvinov, D. N.; He, L.; Banerjee, B.; Castle, S. L.* “Total Synthesis of Celogentin C.” Angew. Chem., Int. Ed. 2009, 48, 6104–6107. Zhang, Y.; Loertscher, B. M.; Castle, S. L.* “An Annulation Method for the Synthesis of Alkyl-substituted 6-Carbomethoxy-2-pyridones.” Tetrahedron 2009, 65, 6584–6590. Li, F.; Tartakoff, S. S.; Castle, S. L.* “Total Synthesis of (–)-Acutumine.” J. Am. Chem. Soc. 2009, 131, 6674–6675. Nielsen, D. K.; Nielsen, L. L.; Jones, S. B.; Toll, L.; Asplund, M. C.; Castle, S. L.* “Synthesis of Isohasubanan Alkaloids via Enantioselective Ketone Allylation and Discovery of an Unexpected Rearrangement.” J. Org. Chem. 2009, 74, 1187–1199. Banerjee, B.; Capps, S. G.; Kang, J.; Robinson, J. W.; Castle, S. L.* “Second-Generation DBFOX Ligands for the Synthesis of -Substituted -Amino Acids via Enantioselective Radical Conjugate Additions.” J. Org. Chem. 2008, 73, 8973–8978.