Austin, Daniel E. - Brigham Young University - Department of Chemistry and Biochemistry

个人简介

BS, Brigham Young University, summa cum laude and University Honors (1998) PhD, Physical Chemistry, California Institute of Technology (2003) Senior Member of Technical Staff, Sandia National Laboratories (2002-2005)

研究领域

My group explores novel instrumentation and applications based on mass spectrometry. There is significant drive to make mass spectrometers sufficiently small and portable that they can be carried to the sample, rather than bringing samples into the lab for analysis. We have pioneered the approach of making mass analyzers using lithographically patterned plates. We have made miniaturized radiofrequency quadrupole, toroidal, and linear ion traps using this approach, as well as an electrostatic ion beam trap. We are also developing charge detector arrays for mass analysis using patterned plates. The use of patterned plates rather than machined electrodes reduces cost while improving the precision and alignment of the electric field. We also study electrospray charging of micron-scale particles. Using mobility experiments we have demonstrated that bacterial spores can survive electrospray charging and desolvation. These spores can subsequently survive impacts against a dense surface at surprisingly high impact speeds. We have also demonstrated that electrospray can be used to electrically charge a variety of mineral types, including quartz, olivine, and chondrite. Electrically charging mineral grains may enable accelerating these particles to high velocities for laboratory simulations of cosmic dust impacts.

近期论文

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Barney, B.; Austin, D.E. Kinetic energy loss of bouncing Bacillus subtilis spores determined using image-charge detection, Journal of Biological Physics, in press. Tian, Y.; Decker, T.K.; McClellan, J.S.; Bennett, L.; Li, A.; De la Cruz, A.; Andrews, D.;Lammert, S.A.; Hawkins, A.R.; Austin, D.E. Improved miniaturized linear ion trap mass spectrometer using lithographically patterned plates and tapered ejection slit, Journal of the American Society for Mass Spectrometry, in press. Li, A.; Higgs, J.; Austin, D.E. Chaotic motion of single ions in a toroidal ion trap mass analyzer, International Journal of Mass Spectrometry, in press. Wang, T.; Zheng, Y.; Wang, X.; Austin, D.E.; Zhang, Z.P. Sub-ppt Mass Spectrometric Detection of Therapeutic Drugs in Complex Biological Matrices Using Polystyrene- Microsphere-Coated Paper Spray, Analytical Chemistry, in press. Austin, D.E. and Lammert, S.A. “Mass Analyzer Miniaturization,” in the Encyclopedia of Mass Spectrometry, vol 7. Elsevier, in press. Wang, T.; Zheng, Y.; Wang, X.; Wang, Q.; Ke, C.-Y.; Austin, D.E.; Han, X.; Zhang, Z. Abnormal Adsorption and Desorption Behaviors of Pharmaceutical Drugs on Polystyrene Microspheres, Advances of the Royal Society of Chemistry, 2017, 7 (32), 19639-19644. Wu, Q.H.; Li, A.; Tian, Y.; Decker, T.; Hawkins, A.R.; Austin, D.E. A miniaturized linear wire ion trap with electron ionization and single photon ionization sources, Journal of the American Society for Mass Spectrometry, 2017, 28, 859-865. Wu, Q.H.; Li, A.; Tian, Y.; Zare, R.N.; Austin, D.E. Miniaturized Linear Wire Ion Trap Mass Analyzer, Analytical Chemistry, 2016, 88, 7800-7806. Barney, B.; Pratt, S.N.; Austin, D.E. Survivability of bare, individual Bacillus subtilis spores to high-velocity surface impact: implications for microbial transfer through space, Planetary and Space Science, 2016, 125, 20−26. Higgs, J.M.; Petersen, B.V.; Lammert, S.A.; Warnick, K.F.; Austin, D.E. Radiofrequency trapping of ions in a pure toroidal potential distribution, International Journal of Mass Spectrometry, 2016, 395, 20−26.