个人简介

Degree in Chemical Engineering (equivalent of B.S.) with honors, Riga Technical University, Latvia, 1990 Doctor of Chemistry (equivalent of Ph.D.) in Organic Chemistry, Riga Technical University, Latvia, 1993

研究领域

Organic and Bioorganic Chemistry

Our research interests are in the chemistry and biochemistry of nucleic acids with a focus on elucidation of RNA’s structure and function. The research philosophy is to use organic chemistry as the enabling discipline to create unique model systems and tools for fundamental studies and practical applications in nucleic acid biochemistry, biophysics and biomedicine. The current projects include design, synthesis, and biophysical exploration of RNA analogs having non-phosphorous internucleoside linkages and development of novel RNA binders for biomedical applications.

近期论文

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Tse, J.; Wang, Y.; Zengeya, T.; Rozners, E.; Tan-Wilson,* A. Peptide nucleic acid probe for protein affinity purification based on biotin-streptavidin interaction and PNA-strand hybridization. Anal. Biochem. 2015, 470, 34-40. Mutisya, D.; Selvam, C.; Lunstad, B. D.; Pallan, P. S.; Haas, A.; Leake, D.; Egli,* M.; Rozners,* E. Amides Are Excellent Mimics of Phosphate Internucleoside Linkages and Are Well Tolerated in Short Interfering RNAs. Nucleic Acid Res. 2014, 42, 6542-6551. Tanui, P., Kennedy, S.D., Lunstad, B.D., Haas, A., Leake, D. and Rozners,* E. Synthesis, biophysical studies and RNA interference activity of RNA having three consecutive amide linkages. Org. Biomol. Chem. 2014, 12, 1207-1210. Zengeya,* T.; Gindin, A.; Rozners, E. Improvement of Sequence Selectivity in Triple Helical Recognition of RNA by Phenylalanine-Derived PNA. Artificial DNA: PNA & XNA 2013, 4, (3) 1-8 (Invited Manuscript). Muse, O.; Zengeya, T.; Mwaura, J.; Hnedzko, D.; McGee, D. W.; Grewer, C. T.; Rozners,* E. Conjugation of Peptide Nucleic Acid with Cationic Peptide Enhances Recognition of Double Helical RNA at Physiologically Relevant Conditions. ACS Chem. Biol. 2013, 8, 1683-1686. Walsh, J. M.; Ippoliti, P. J.; Ronayne, E. A.; Rozners, E.; Beuning,* P. J., Discrimination against major groove adducts by Y-family polymerases of the DinB subfamily. DNA Repair 2013, 12, 713-722. Zengeya, T.; Gupta, P.; Rozners,* E. Triple Helical Recognition of RNA Using 2-Aminopyridine-Modified PNA at Physiologically Relevant Conditions. Angew. Chem., Int. Ed. 2012, 51, 12593-12596 (Very Important Paper). Patra, A.; Paolillo, M.; Charisse, K.; Manoharan, M.; Rozners,* E.; Egli,* M. 2′-Fluoro RNA Shows Increased Watson-Crick H-Bonding Strength and Stacking Relative to RNA: Evidence from NMR and Thermodynamic Data. Angew. Chem., Int. Ed. 2012, 51, 11863-11866. Walsh, J. M.; Parasuram, R.; Rajput, P. R.; Rozners, E.; Ondrechen, M. J.; Beuning,* P. J., Effects of non-catalytic, distal amino acid residues on activity of E. coli DinB (DNA polymerase IV). Environ. Mol. Mutagen. 2012, 53 (9), 766-776. Gupta, P.; Muse, O., Rozners,* E. Recognition of Double Stranded RNA by Guanidine-Modified Peptide Nucleic Acids (GPNA). Biochemistry, 2012, 51, 63-73. Gupta, P.; Zengeya, T., Rozners,* E. Triple Helical Recognition of Pyrimidine Inversions in Polypurine Tracts of RNA by Nucleobase-modified PNA Chem. Commun. 2011, 47, 11125-11127. Mutisya, D.; Selvam, C.; Kennedy, S. D.; Rozners,* E. Synthesis and properties of triazole-linked RNA. Bioorg. Med. Chem. Lett. 2011, 21, 3420-3422. Pallan, P.S.; Greene, E. M.; Jicman, P. A.; Pandey, R. K.; Manoharan, M.; Rozners,* E.; Egli,* M. Unexpected origins of the enhanced pairing affinity of 2′-fluoro-modified RNA. Nucleic Acids Res. 2011, 39, 3482-3495. Zengeya, T.; Li, M.; Rozners,* E. PNA containing isocytidine nucleobase: synthesis and recognition of double helical RNA. Bioorg. Med. Chem. Lett. 2011, 21, 2121-2124. Selvam, C.; Thomas, S.; Abbott, J.; Kennedy, S. D.; Rozners,* E. Amides Are Excellent Mimics of Phosphate Linkages in RNA Angew. Chem. Int. Ed. 2011, 50, 2068-2070. Manoharan,* M.; Akinc, A.; Pandey, R. K.; Qin, J.; Hadwiger, P.; John, M.; Mills, K.; Charisse, K.; Maier, M. A.; Nechev, L.; Greene, E. M.; Pallan, P. S.; Rozners, E.; Rajeev, K. G.; Egli,* M. Unique Gene-silencing and Structural Properties of 2′-F Modified siRNAs. Angew. Chem. Int. Ed. 2011, 50, 2284-2288 (Featured as a Hot Paper chosen by the Editors). Li, M.; Zengeya, T.; Rozners,* E. Short Peptide Nucleic Acids Bind Strongly to Homopurine Tract of Double Helical RNA at pH 5.5. J. Am. Chem. Soc. 2010, 132, 8676-8681. Tanui, P.; Kullberg, M.; Song, N.; Chivate, Y.; Rozners,* E. Monomers for preparation of amide linked RNA: synthesis of C3'-homologated nucleoside amino acids from D-xylose. Tetrahedron 2010, 66, 4961-4964. Kolarovic, A.; Schweizer, E.; Greene, E.; Gironda, M.; Pallan, P. S.; Egli, M.; Rozners,* E. Interplay of Structure, Hydration and Thermal Stability in Formacetal Modified Oligonucleotides: RNA May Tolerate Nonionic Modifications Better than DNA. J. Am. Chem. Soc. 2009, 131, 14932-14937. Li, F.; Pallan, P.; Maier, M.; Rajeev, K.; Mathieu, S.; Kreutz, C.; Fan, Y.; Sanghvi, J.; Micura, R.; Rozners, E.; Manoharan, M.; Egli,* M. Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme Nucleic Acids Res., 2007, 35, 6424-6438.