个人简介

Ph.D Washington University, St Louis, MO 2004 B.S. Calvin College, Grand Rapids, MI 1992 Postdoctoral Fellow Washington University, St. Louis, MO 2004-2006 Research Associate Washington University, St. Louis, MO 2006-2011 Professional Experience Assistant Professor of Biochemistry Baylor University 2011 - present

研究领域

Biochemistry and Biophysics

Combined solid-state NMR and biophysical methods are used to characterize the chemical compositions and structures of complex biological solids. Some of research interests include i) structural characterization of antimicrobial cyclic peptide binding sites in Gram-positive pathogens, S. aureus and E. faecalis, ii) compositional analysis of extracellular matrices of bacterial cell surface, and iii) carbon-flux analysis for lipid biosynthesis in green alga Chlamydomonas reinhardtii.

近期论文

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Peptidoglycan architecture of Gram-positive bacteria by solid-state NMR SJ Kim, J Chang, M Singh Biochimica et Biophysica Acta Biomembrane: Vol. 1848 (1): 350-362 2015 REDOR constraints on the peptidoglycan lattice architecture of Staphylococcus arueus and its FemA mutant M Singh, SJ Kim, S Sharif, MN Preobrazhenskaya, J Schaefer Biochimica et Biophysica Acta Biomembrane: Vol. 1848 (1): 363-368 2015 Cross-link Formation and Peptidoglycan Lattice Assembly in the FemA Mutant of Staphylococcus aureus SJ Kim, M Singh, S Sharif, J Schaefer Biochemistry, Vol. 53 (9): 1420-1427. 2014 Staphylococcus aureus Peptidoglycan Stem Packing by Rotational-Echo Double Resonance NMR Spectroscopy SJ Kim, M Singh, MN Preobrazhenskaya, J Schaefer Biochemistry, Vol. 52 (21): 3651-3659 2013 Locations of the hydrophobic side chains of lipoglycopeptides bound to the peptidoglycan of Staphylococcus aureus SJ Kim, KSE Tanaka, E Dietrich, A Rafai Far, J Schaefer Biochemistry, Vol. 52 (20): 3405-3414. 2013 Uniformity of Glycyl Bridge Lengths in the Mature Cell Walls of Fem Mutants of Methicillin-ResistantStaphylococcus aureus S Sharif, SJ Kim, H Labischinski, J Chen, J Schaefer Journal of Bacteriology, Vol. 195 (7), 1421-1427. 2013 Isotridecanyl side chain of plusbacin-A3 is essential for the transglycosylase inhibition of peptidoglycan biosynthesis SJ Kim, M Singh, A Wohlrab, TY Yu, GJ Patti, RD O’Connor, MS VanNieuwenhze … Biochemistry, Vol. 52 (11): 1973-1979. 2013 Vancomycin and oritavancin have different modes of action in Enterococcus faecium GJ Patti, SJ Kim, TY Yu, E Dietrich, KSE Tanaka, TR Parr Jr, AR Far, J Schaefer Journal of Molecular Biology, Vol. 392 (5), 1178. 2009 Oritavancin Binds to Isolated Protoplast Membranes but not Intact Protoplasts of Staphylococcus aureus SJ Kim, M Singh, J Schaefer Journal of Molecular Biology, Vol. 391 (2), 414-425. 2009 Staphylococcus aureus peptidoglycan tertiary structure from carbon-13 spin diffusion S Sharif, M Singh, SJ Kim, J Schaefer Journal of the American Chemical Society, Vol. 131 (20), 7023-7030. 2009 Characterization of Peptidoglycan in Fem-Deletion Mutants of Methicillin-Resistant Staphylococcus aureus by Solid-State NMR S Sharif, SJ Kim, H Labischinski, J Schaefer Biochemistry, Vol. 48 (14), 3100-3108. 2009 Hydrophobic Side-Chain Length Determines Activity and Conformational Heterogeneity of a Vancomycin Derivative Bound to the Cell Wall of Staphylococcus aureus SJ Kim, J Schaefer Biochemistry, Vol. 47 (38), 10155-10161. 2008 Characterization of the Peptidoglycan of Vancomycin-Susceptible Enterococcus faecium GJ Patti, SJ Kim, J Schaefer Biochemistry, Vol. 47 (32), 8378-8385. 2008 Oritavancin Exhibits Dual Mode of Action to Inhibit Cell-Wall Biosynthesis in Staphylococcus aureus SJ Kim, L Cegelski, D Stueber, M Singh, E Dietrich, KSE Tanaka, TR Parr Jr … Journal of Mmolecular Biology, Vol. 377 (1), 281-293. 2008 Vancomycin Derivative with Damaged d-Ala-d-Ala Binding Cleft Binds to Cross-linked Peptidoglycan in the Cell Wall of Staphylococcus aureus SJ Kim, S Matsuoka, GJ Patti, J Schaefer Biochemistry, Vol. 47 (12), 3822-3831. 2008 Structures of Staphylococcus aureus cell-wall complexes with vancomycin, eremomycin, and chloroeremomycin derivatives by 13C{19F} and 15N{19F} rotational-echo double resonance SJ Kim, L Cegelski, M Preobrazhenskaya, J Schaefer Biochemistry 45 (16), 5235-5250 2006 Secondary structure and lipid contact of a peptide antibiotic in phospholipid bilayers by REDOR O Toke, W Lee Maloy, SJ Kim, J Blazyk, J Schaefer Biophysical Journal, Vol. 87 (1), 662-674. 2004 Rotational-echo double resonance characterization of the effects of vancomycin on cell wall synthesis inStaphylococcus aureus L Cegelski, SJ Kim, AW Hing, DR Studelska, RD O’Connor, AK Mehta, J Schaefer Biochemistry, Vol. 41 (43), 13053-13058. 2002 Rotational-echo double resonance characterization of vancomycin binding sites in Staphylococcus aureus SJ Kim, L Cegelski, DR Studelska, RD O’Connor, AK Mehta, J Schaefer Biochemistry, Vol. 41 (22), 6967-6977. 2002 The Contribution of Adjacent Subunits to the Active Sites ofd-3-Phosphoglycerate Dehydrogenase GA Grant, SJ Kim, XL Xu, Z Hu Journal of Biological Chemistry, Vol. 274 (9), 5357-5361. 1999