刘文广 - 天津大学 - 材料科学与工程学院

个人简介

教育背景： 1996年6月-1999年4月天津大学材料科学与工程学院生物医学工程专业博士 1993年9月-1996年3月天津大学应用化学系高分子材料专业硕士 1987年7月-1991年9月天津大学应用化学系高分子化工专业学士工作经历： 2007年7月-至今天津大学材料科学与工程学院教授 1999年7月-2007年6月天津大学材料科学与工程学院讲师、副教授 2005年3月-2006年11月加拿大渥太华大学博士后 2004年3月-2004年11月香港理工大学 Research Associate 2003年7月-2004年1月香港大学医学院骨科系访问学者主要学术成就、获奖及荣誉：中国生物材料学会生物医用高分子分会委员，《中国科学：技术科学》杂志（EI收录）、Science China Technological Sciences(SCI收录)编委。主要从事水凝胶、药物/基因递送载体等生物医用高分子材料的研究，曾获得天津市自然科学一二等奖，2006年入选教育部新世纪优秀人才计划，2012年天津市教工先锋岗先进个人，2013年获得国家杰出青年科学基金资助，2015年获得天津市五一劳动奖章，2016年天津市教育系统优秀共产党员，2016年入选国务院特殊津贴专家，2017年被评为天津大学第十届“我心目中的好导师”。

研究领域

再生医学相关生物医用高分子材料高强度水凝胶的设计及其生物医学应用药物/基因递送载体功能高分子材料

近期论文

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A gel microparticle-based self-thickening strategy for 3D printing high-modulus hydrogels skeleton cushioned with PNAGA hydrogel mimicking anisotropic mechanics of meniscus Bioactive Materials 2023-08 | Journal article DOI: 10.1016/j.bioactmat.2023.02.020 CONTRIBUTORS: Ziyang Xu; Qian Zhang; Chuanchuan Fan; Meng Xiao; Rong Yang; Yuan Yao; Yang Wu; Xiongfeng Nie; Hongying Wang; Wenguang Liu A Coenzyme-Based Deep Eutectic Supramolecular Polymer Bioadhesive Chunyan Cui, Yage Sun, Xiongfeng Nie, Xuxuan Yang, Fushuo Wang, Wenguang Liu First published: 19 July 2023 https://doi.org/10.1002/adfm.202307543 YAP-Suppressive Nanodrug Crosslinked Self-Immunoregulatory Polysaccharide Injectable Hydrogel for Attenuating Cardiac Fibrosis to Treat Myocardial Infarction Yage Sun, Xiaoping Zhang, Tengling Wu, Zhuodan Zhang, Rong Yang, Wenguang Liu First published: 28 February 2023 https://doi.org/10.1002/adfm.202214468 An Injectable and Antifouling Supramolecular Polymer Hydrogel with Microenvironment-Regulatory Function to Prevent Peritendinous Adhesion and Promote Tendon Repair Kuan Wang, Danyang Chen, Zhuoya Wang, Jianhai Yang, Wenguang Liu First published: 14 June 2023 https://doi.org/10.1002/mabi.202300142 CO enhances agomir transfection under pathological conditions to inhibit MMP overexpression Xin Jin , Zelin Ou , Xue Huang , Lin Shi b, Rong Shi , Jue Wang , Jumin Yang , Kejing Fang , Jing Yang , Dalun Lv , Chang Wang , Zhixian Yuan , Wenhong li , Wenguang Liu , Gaoxing Luo , Jun Deng , Wei Wang https://doi.org/10.1016/j.nantod.2023.101898 A Unified Therapeutic–Prophylactic Tissue-Engineering Scaffold Demonstrated to Prevent Tumor Recurrence and Overcoming Infection toward Bone Remodeling Yongkang Huang, Xinyun Zhai, Tengfei Ma, Mengzhen Zhang, Houzhi Yang, Shuai Zhang, Junbo Wang, Wenguang Liu, Xin Jin, William Weijia Lu, Xiaoli Zhao, Weiyu Hou, Tianwei Sun, Jie Shen, Haobo Pan, Yaping Du, Chun-Hua Yan First published: 20 March 2023 https://doi.org/10.1002/adma.202300313 Combined intramyocardial injectable hydrogel and pericardial adhesive hydrogel patch therapy strategy to achieve gene/ion/gas delivery for improving cardiac function Zhang Xiaoping,Sun Yage,Wu Tengling,Zhao Xinrui,Yang Rong,Wang Hongying,Liu Wenguang Page:101861 ISSN:1748-0132 2023 Container-title:Nano Today Environmentally Stable, Robust, Adhesive, and Conductive Supramolecular Deep Eutectic Gels as Ultrasensitive Flexible Temperature Sensor Puqing Yao, Qiwen Bao, Yuan Yao, Meng Xiao, Ziyang Xu, Jianhai Yang, Wenguang Liu First published: 27 February 2023 https://doi.org/10.1002/adma.202300114 3D-printed tough zwitterionic polycarbonate polyurethane meniscus substitute ameliorates cartilage abrasion 3D打印强韧两性离子聚碳酸酯聚氨酯半月板替代物用于改善软骨磨损 Yang Wu (吴阳), Qian Zhang (张倩), Xuxuan Yang (杨徐轩), Xiaoping Zhang (张晓平), Xiongfeng Nie (聂雄峰), Meng Xiao (肖萌), Yuan Yao (姚远), Ziyang Xu (徐子扬) & Wenguang Liu (刘文广) Science China Materials volume 66, pages3744–3756 (2023) A bilayered scaffold with segregated hydrophilicity-hydrophobicity enables reconstruction of goat hierarchical temporomandibular joint condyle cartilage Acta Biomaterialia 2021 | Journal article DOI: 10.1016/j.actbio.2020.11.031 EID: 2-s2.0-85096843482 Part of ISSN: 18787568 17427061 CONTRIBUTORS: Yu, X.; Hu, Y.; Zou, L.; Yan, S.; Zhu, H.; Zhang, K.; Liu, W.; He, D.; Yin, J. A Self-Thickening and Self-Strengthening Strategy for 3D Printing High-Strength and Antiswelling Supramolecular Polymer Hydrogels as Meniscus Substitutes Advanced Functional Materials 2021 | Journal article DOI: 10.1002/adfm.202100462 EID: 2-s2.0-85101308364 Part of ISSN: 16163028 1616301X CONTRIBUTORS: Xu, Z.; Fan, C.; Zhang, Q.; Liu, Y.; Cui, C.; Liu, B.; Wu, T.; Zhang, X.; Liu, W. A Short Review on Self-Healing Thermoplastic Polyurethanes Macromolecular Chemistry and Physics 2021 | Journal article DOI: 10.1002/macp.202100002 EID: 2-s2.0-85102747033 Part of ISSN: 15213935 10221352 CONTRIBUTORS: Yao, Y.; Xiao, M.; Liu, W. A Solvent-Free and Water-Resistant Dipole–Dipole Interaction-Based Super Adhesive Macromolecular Rapid Communications 2021 | Journal article DOI: 10.1002/marc.202100010 EID: 2-s2.0-85101633107 Part of ISSN: 15213927 10221336 CONTRIBUTORS: Liu, B.; Xu, Z.; Fan, C.; Cui, C.; Yao, Y.; Xiao, M.; Liu, W. An in situ-forming polyzwitterion hydrogel: Towards vitreous substitute application Bioactive Materials 2021 | Journal article DOI: 10.1016/j.bioactmat.2021.02.029 EID: 2-s2.0-85102129687 Part of ISSN: 2452199X CONTRIBUTORS: He, B.; Yang, J.; Liu, Y.; Xie, X.; Hao, H.; Xing, X.; Liu, W. An injectable and antifouling self-fused supramolecular hydrogel for preventing postoperative and recurrent adhesions Chemical Engineering Journal 2021 | Journal article DOI: 10.1016/j.cej.2020.127096 EID: 2-s2.0-85091778779 Part of ISSN: 13858947 CONTRIBUTORS: Zhao, X.; Yang, J.; Liu, Y.; Gao, J.; Wang, K.; Liu, W. An injectable hydrogel to reverse the adverse microenvironment of diabetic infarcted heart Materialia 2021 | Journal article DOI: 10.1016/j.mtla.2020.100957 EID: 2-s2.0-85097402128 Part of ISSN: 25891529 CONTRIBUTORS: Chen, S.; Han, X.; Zou, Y.; Shang, Y.; Liu, C.; Jin, X.; Li, Y.; Lyu, Y.; Zhang, Z.; Yang, Z. et al. An Ultrasoft Self-Fused Supramolecular Polymer Hydrogel for Completely Preventing Postoperative Tissue Adhesion Advanced Materials 2021 | Journal article DOI: 10.1002/adma.202008395 EID: 2-s2.0-85102629266 Part of ISSN: 15214095 09359648 CONTRIBUTORS: Yu, J.; Wang, K.; Fan, C.; Zhao, X.; Gao, J.; Jing, W.; Zhang, X.; Li, J.; Li, Y.; Yang, J. et al. A high-strength polyacrylic acid-based adhesive hydrogel,高强度聚丙烯酸基黏附水凝胶 Zhongguo Kexue Jishu Kexue/Scientia Sinica Technologica 2020 | Journal article DOI: 10.1360/SST-2019-0441 EID: 2-s2.0-85090787494 Part of ISSN: 2095946X 16747259 CONTRIBUTORS: Wang, M.; Wu, T.; Liu, B.; Cui, C.; Yang, J.; Liu, W. A Janus Hydrogel Wet Adhesive for Internal Tissue Repair and Anti-Postoperative Adhesion Advanced Functional Materials 2020 | Journal article DOI: 10.1002/adfm.202005689 EID: 2-s2.0-85090793102 Part of ISSN: 16163028 1616301X CONTRIBUTORS: Cui, C.; Wu, T.; Chen, X.; Liu, Y.; Li, Y.; Xu, Z.; Fan, C.; Liu, W. A robust poly(: N-Acryloyl-2-glycine)-based sponge for rapid hemostasis Biomaterials Science 2020 | Journal article DOI: 10.1039/d0bm00770f EID: 2-s2.0-85087467882 Part of ISSN: 20474849 20474830 CONTRIBUTORS: Chen, X.; Cui, C.; Liu, Y.; Fan, C.; Xiao, M.; Zhang, D.; Xu, Z.; Li, Y.; Yang, J.; Liu, W. A smart indwelling needle with on-demand switchable anticoagulant and hemostatic activities Materials Horizons 2020 | Journal article DOI: 10.1039/c9mh01619h EID: 2-s2.0-85083232123 Part of ISSN: 20516355 20516347 CONTRIBUTORS: Wu, Y.; Wang, H.; Fan, C.; Xu, Z.; Liu, B.; Liu, W. Wu, Y.; Wang, H.; Gao, F.; Xu, Z.; Dai, F.; Liu, W*., An Injectable Supramolecular Polymer Nanocomposite Hydrogel for Prevention of Breast Cancer Recurrence with Theranostic and Mammoplastic Functions. Adv. Funct. Mater. 2018, 1801000. Liang, S.; Zhang, Y.; Wang, H.; Xu, Z.; Chen, J.; Bao, R.; Tan, B.; Cui, Y.; Fan, G.; Wang, W.; Wang, W*.; Liu, W*., Paintable and Rapidly Bondable Conductive Hydrogels as Therapeutic Cardiac Patches. Adv. Mater. 2018, 30, e1704235. Gao, F.; Xu, Z.; Liang, Q.; Liu, B.; Li, H.; Wu, Y.; Zhang, Y.; Lin, Z.; Wu, M.; Ruan, C*.; Liu, W*., Direct 3d Printing of High Strength Biohybrid Gradient Hydrogel Scaffolds for Efficient Repair of Osteochondral Defect. Adv. Funct. Mater. 2018, 1706644. Zhang, Y.; Gao, H.; Wang, H.; Xu, Z.; Chen, X.; Liu, B.; Shi, Y.; Lu, Y.; Wen, L.; Li, Y.; Li, Z.; Men, Y.; Feng, X*.; Liu, W*., Radiopaque Highly Stiff and Tough Shape Memory Hydrogel Microcoils for Permanent Embolization of Arteries. Adv. Funct. Mater. 2018, 28, 1705962. Li, M.; Sun, X.; Zhang, N.; Wang, W.; Yang, Y.; Jia, H*.; Liu, W*., Nir-Activated Polydopamine-Coated Carrier-Free “Nanobomb” for in Situ on-Demand Drug Release. Advanced Science 2018, 1800155. Wang, W.; Tan, B.; Chen, J.; Bao, R.; Zhang, X.; Liang, S.; Shang, Y.; Liang, W.; Cui, Y.; Fan, G.; Jia, H*.; Liu, W*., An Injectable Conductive Hydrogel Encapsulating Plasmid DNA-Enos and Adscs for Treating Myocardial Infarction. Biomaterials 2018, 160, 69-81.