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个人简介

2018 - 2020 Managing Director, Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany since 2015 Director at the Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany 2015 - 2017 Visiting Professor, Harvard University, Cambridge, USA 2012 - 2015 Professor of Chemistry and Chemical Biology, Harvard University, Cambridge, USA since 2011 Co-founder SciFluor Life Sciences, now OcuTerra Therapeutics, Boston, USA since 2010 Chemist at the Massachusetts General Hospital, Boston, USA 2010 - 2012 Associate Professor for Chemistry and Chemical Biology, Harvard University, Cambridge, USA 2006 - 2010 Assistant Professor of Chemistry and Chemical Biology, Harvard University, Cambridge, USA 2004 - 2006 Post-Doctoral Fellow, California Institute of Technology, Pasadena, USA 2004 Ph.D. Organic Chemistry, ETH Zürich, Schweiz 1999 Master of Science, Technische Universität Braunschweig, Germany 1975 born in Lübeck, Germany

研究领域

Research in the Ritter group focuses on the development of novel reaction chemistry. We seek to discover molecular structure and reactivity that can contribute to interdisciplinary solutions for challenges in science. The lab focuses on synthetic organic and organometallic chemistry, complex molecule synthesis, and mechanistic studies to develop practical access to molecules of interest in catalysis, medicine, and materials.

近期论文

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Ni, S.; Halder, R.; Ahmadli, D.; Reijerse, E. J.; Cornella, J.; Ritter, T. C–Heteroatom Coupling with Electron-Rich Aryls Enabled by Nickel Catalysis and Light. Nature Catalysis 2024. Mateos, J.; Schulte, T.; Behera, D.; Leutzsch, M.; Altun, A.; Sato, T.; Waldbach, F.; Schnegg, A.; Neese, F.; Ritter, T. Nitrate Reduction Enables Safer Aryldiazonium Chemistry. Science 2024, 384, 446–452. Cai, Y.; Gaurav, G.; Ritter, T. 1,4-Aminoarylation of Butadienes Via Photoinduced Palladium Catalysis. Angewandte Chemie International Edition 2024, 63, e202311250. Hartmann, P.; Bohdan, K.; Hommrich, M.; Juliá, F.; Vogelsang, L.; Eirich, J.; Zangl, R.; Farès, C.; Jacobs, J. B.; Mukhopadhyay, D.; Mengeler, J. M.; Vetere, A.; Sterling, M. S.; Hinrichs, H.; Becker, S.; Morgner, N.; Schrader, W.; Finkemeier, I.; Dietz, K.-J.; Griesinger, C.; Ritter, T. Chemoselective Umpolung of Thiols to Episulfoniums for Cysteine Bioconjugation. Nature Chemistry 2024, 16, 380–388. Lansbergen, B.; Tewari, S.; Tomczyk, I.; Seemann, M.; Buchholz, H. L.; Rippegarten, M.; Chamier Cieminski, D.; Juliá, F.; Ritter, T. Reductive Cross-Coupling of a Vinyl Thianthrenium Salt and Secondary Alkyl Iodides. Angewandte Chemie International Edition 2023, 62, e202313659. Bai, Z.; Lansbergen, B.; Ritter, T. Bicyclopentylation of Alcohols with Thianthrenium Reagents. Journal of the American Chemical Society 2023, 145, 25954–25961. Kim, J.; Müller, S.; Ritter, T. Synthesis of α-Branched Enones Via Chloroacylation of Terminal Alkenes. Angewandte Chemie International Edition 2023, 62, e202309498. Hamad, A.; Mrozowicz, M.; Xie, Y.; Ritter, T. Regioselective Double C–H Functionalization of Arenes Via Aryl Thianthrenium Salt Analogues. Synlett 2023, 34, A-E. Halder, R.; Ma, G.; Rickmeier, J.; McDaniel, J. W.; Petzold, R.; Neumann, C. N.; Murphy, J. M.; Ritter, T. Deoxyfluorination of Phenols for Chemoselective 18F-Labeling of Peptides. Nature Protocols 2023, 18, 3614–3651. Zhang, L.; Yan, J.; Ahmadli, D.; Wang, Z.; Ritter, T. Electron-Transfer-Enabled Concerted Nucleophilic Fluorination of Azaarenes: Selective C–H Fluorination of Quinolines. Journal of the American Chemical Society 2023, 145, 20182–20188. Cai, Y.; Chatterjee, S.; Ritter, T. Photoinduced Copper-Catalyzed Late-Stage Azidoarylation of Alkenes Via Arylthianthrenium Salts. Journal of the American Chemical Society 2023, 145, 13542–13548. Alvarez, E. M.; Bai, Z.; Pandit, S.; Frank, N.; Torkowski, L.; Ritter, T. O-, N- And C-Bicyclopentylation Using Thianthrenium Reagents. Nature Synthesis 2023, 2, 548–556. Ni, S.; Yan, J.; Tewari, S.; Reijerse, E. J.; Ritter, T.; Cornella, J. Nickel Meets Aryl Thianthrenium Salts: Ni(I)-Catalyzed Halogenation of Arenes. Journal of the American Chemical Society 2023, 145, 9988–9993. Su, W.; Xu, P.; Petzold, R.; Yan, J.; Ritter, T. Ligand-to-Copper Charge-Transfer-Enabled C–H Sulfoximination of Arenes. Organic Letters 2023, 25, 1025–1029. Kim, J.; Sun, X.; van der Worp, B. A.; Ritter, T. Anti-Markovnikov Hydrochlorination and Hydronitrooxylation of α-Olefins Via Visible-Light Photocatalysis. Nature Catalysis 2023, 6, 196–203. Xu, P.; Su, W.; Ritter, T. Decarboxylative Sulfoximination of Benzoic Acids Enabled by Photoinduced Ligand-to-Copper Charge Transfer. Chemical Science 2022, 13, 13611–13616. Cai, Y.; Ritter, T. Meerwein-Type Bromoarylation with Arylthianthrenium Salts. Angewandte Chemie, International Edition 2022, 61, e202209882. Jia, H.; Ritter, T. α-Thianthrenium Carbonyl Species: The Equivalent of an α-Carbonyl Carbocation. Angewandte Chemie International Edition 2022, 61, e202208978. Cheng, Q.; Bai, Z.; Tewari, S.; Ritter, T. Bifunctional Sulfilimines Enable Synthesis of Multiple N-Heterocycles from Alkenes. Nature Chemistry 2022, 14, 898–904. Zhang, L.; Israel, E. M.; Yan, J.; Ritter, T. Copper-Mediated Etherification Via Aryl Radicals Generated from Triplet States. Nature Synthesis 2022, 1, 376–381. Berger, F.; Ritter, T. Site-Selective Late-Stage C–H Functionalization Via Thianthrenium Salts. Synlett 2022, 33, 339–345. Zhang, L.; Ritter, T. A Perspective on Late-Stage Aromatic C–H Bond Functionalization. Journal of the American Chemical Society 2022, 144, 2399–2414. Zhao, D.; Petzold, R.; Yan, J.; Muri, D.; Ritter, T. Tritiation of Aryl Thianthrenium Salts with a Molecular Palladium Catalyst. Nature 2021, 600, 444–449. Su, W.; Xu, P.; Ritter, T. Decarboxylative Hydroxylation of Benzoic Acids. Angewandte Chemie International Edition 2021, 60, 24012–24017. Halder, R.; Ritter, T. 18F-Fluorination: Challenge and Opportunity for Organic Chemists. The Journal of Organic Chemistry 2021, 86, 13873–13884. Juliá, F.; Shao, Q.; Duan, M.; Plutschack, M. B.; Berger, F.; Mateos, J.; Lu, C.; Xue, X.-S.; Houk, K. N.; Ritter, T. High Site Selectivity in Electrophilic Aromatic Substitutions: Mechanism of C–H Thianthrenation. Journal of the American Chemical Society 2021, 143, 16041–16054. Juliá, F.; Yan, J.; Paulus, F.; Ritter, T. Vinyl Thianthrenium Tetrafluoroborate: A Practical and Versatile Vinylating Reagent Made from Ethylene. Journal of the American Chemical Society 2021, 143, 12992–12998. Alvarez, E. M.; Karl, T.; Berger, F.; Torkowski, L.; Ritter, T. Late‐Stage Heteroarylation of Hetero(Aryl)Sulfonium Salts Activated by α‐Amino Alkyl Radicals. Angewandte Chemie International Edition 2021, 60, 13609–13613. Lansbergen, B.; Granatino, P.; Ritter, T. Site-Selective C–H Alkylation of Complex Arenes by a Two-Step Aryl Thianthrenation-Reductive Alkylation Sequence. Journal of the American Chemical Society 2021, 143, 7909–7914. Jia, H.; Häring, A. P.; Berger, F.; Zhang, L.; Ritter, T. Trifluoromethyl Thianthrenium Triflate: A Readily Available Trifluoromethylating Reagent with Formal CF3+, CF3•, and CF3– Reactivity. Journal of the American Chemical Society 2021, 143, 7623–7628. Sun, X.; Ritter, T. Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids. Angewandte Chemie International Edition 2021, 60, 10557–10562. Xu, P.; López-Rojas, P.; Ritter, T. Radical Decarboxylative Carbometalation of Benzoic Acids: A Solution to Aromatic Decarboxylative Fluorination. Journal of the American Chemical Society 2021, 143, 5349–5354.

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