Kaplan, David - Tufts University - Department of Biomedical Engineering

个人简介

Education 1975 B.S., SUNY, Albany 1978 Ph.D., Syracuse University and SUNY Syracuse Professional Experience 2012-pres. Chair, NIH Study Section – BMBI - Biomaterials and Biointerfaces 2006-pres. Stern Family Endowed Professor of Bioengineering – Tufts University 2002-pres. Professor & Chair, Department of Biomedical Engineering 2006-pres. Professor – Tufts University School of Medicine, Sackler School of Graduate Biomedical Sci, Program in Cell, Molecular, Developmental Biology 2005-pres. Professor, Secondary Appointment – Tufts University School of Dental Medicine 2004-pres. Director, NIH P41 Tissue Engineering Resource Center 2000-pres. Professor, Secondary Appointment – Dept. Chemistry, Tufts University

研究领域

Research Interests The Kaplan lab research focus is on biopolymer engineering to understand structure-function relationships, with emphasis on studies related to self-assembly, biomaterials engineering, tissue engineering and regenerative medicine. The studies include a variety of structural proteins, including collagens, elastins, resilins and silks. In addition, the lab has pioneered the study of silk-based biomaterials in regenerative medicine, starting from fundamental studies of the biochemistry, molecular biology and biophysical features of this novel class of fibrous proteins to their impact on stem cell functions and complex tissue formation. The result has been the emergence of silk as a new option in the degradable polymer field with excellent biocompatibility, new fundamental understanding of control of water to regulate structure and properties, and new tissue-specific outcomes with silk as scaffolding in gel, fiber, film or sponge formats. Studies are also focused on tissue engineering and regenerative medicine with the use of complex 3D tissue co-culture systems to establish and study human tissues in the laboratory and in animal systems. These systems are also used to study diseases associated with brain, intestine, kidney, obesity, diabetes and cancers, including for therapeutic screening. Interfaces with optical imaging tools are also exploited.

近期论文

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Alberti KA, Hopkins AM, Tang-Schomer MD, Kaplan DL, Xu Q. The behaviour of neuronal cells on tendon-derived collagen sheets as potential substrates for nerve regeneration. Biomaterials, 35(11): 3551-3557 (2014) [PMID 24461939] An B, Abbonante V, Yigit S, Balduini A, Kaplan DL, Brodsky B. Definition of the native and denatured type II collagen binding site for fibronectin using a recombinant collagen system. J. Biological Chemistry 289(8): 4941-4951 (2014) [PMID 24375478] Blasioli DJ, Matthews GL, Kaplan DL. The degradation of chondrogenic pellets using cocultures of synovial fibroblasts and U937 cells. Biomaterials 35(4): 1185-1191 (2014) [PMID 24225084] Critchfield AS, McCabe R, Klebanov N, Richey L, Socrate S, Norwitz ER, Kaplan DL, House M. Biocompatibility of a sonicated silk gel for cervical injection during pregnancy: in vivo and in vitro study. Reproductive Science Feb 11 ahead of print (2014) [PMID 24520079] Giesa T, Pugno NM, Wong JY, Kaplan DL, Buehler MJ. What’s inside the box? – Length scales that govern fracture processes of polymer fibers. Advanced Materials 26(3):412-417 [PMID 24431127] Gil ES, Park SH, Hu X, Cebe P, Kaplan DL. Impact of sterilization on the enzymatic degradation and mechanical properties of silk biomaterials. Macromolecular Bioscience 14(2): 257-269 (2014) [PMID 24519787] Han F, Liu S, Liu X, Pei Y, Bai S., Zhao H, Lu Q., Ma F., Kaplan DL, Zhu H. Woven silk fabric-reinforced silk nanofibrous scaffolds for regenerating load-bearing soft tissues. Acta Biomaterialia, 10(2):921-930 (2014) [PMID 24090985] Hayden RS, Vollrath M, Kaplan DL. Effects of clodronate and alendronate on osteoclast and osteoblast co-cultures on silk-hydroxyapatite films. Acta Biomaterialia 10(1): 486-493 (2014) [PMID 24096150] Hayden RS, Quinn KP, Alonzo CA, Georgakoudi I, Kaplan DL. Quantitative characterization of mineralized silk film remodelling during long term osteoblast-osteoclast co-culture. Biomaterials 35(12): 3794-3802 (2014) [PMID 24484674] House M, Tadesse-Telila S, Norwitz ER, Socrate S, Kaplan DL. Inhibitory effect of progesterone on cervical tissue formation in a three-dimensional culture system with human cervical fibroblasts. Biol. Reproduction 90(1): 18 (2014) [PMID 24285720] Khalid A, Lodin R, Domachuk P, Tao H, Moreau JE, Kaplan DL, Omenetto FG, Gibson BC, Tomljenovic-Hanic S. Synthesis and characterization of biocompatible nanodiamond-silk hybrid material. Biomedical Topics Express 5(2): 596- 608 (2014) [PMID 24575352] Lescarbeau R, Kaplan DL. Correlating phosphoproteomic signaling with castration resistant prostate cancer survival through regression analysis. Molecular Biosystems, 10(3): 605-612 (2014) [PMID 24413303] Mahmood A, Wu H, Qu C, Mahmood S, Xiong Y, Kaplan DL, Chopp M. Suppression of neurocan and enhancement of axonal density in rats after treatment to f traumatic brain injury with scaffolds impregnated with bone marrow stromal cells. J. Neurosurgery, ahead of print (2014) [PMID24460490] Mitropoulos AN, Perotto G, Kim S, Marelli B, Kaplan DL, Omenetto FG, Synthesis of silk fibroin micro- and submicron spheres using a co-flow capillary device, Advanced Materials, 26(7): 1105-1120, (2014) [PMID 24339048] Pallotta I, Kluge JA, Moreau J, Calabrese R, Kaplan DL, Balduini A. Characteristics of platelet gels combined with silk. Biomaterials, 35(11): 3678-3687 (2014) [PMID 24480538] Qin, G., Panilaitis, B.J., Kaplan, D.L. A cellulosic responsive living membrane. Carbohydrate Polymers, 100: 40-45 (2014) Seib FP, Herklotz M, Burke KA, Maitz MF, Werner C, Kaplan DL. Multifunctional silk-heparin biomaterials for vascular tissue engineering applications. Biomaterials 35(1):83-91 (2014) [PMID 24099708] Tang-Schomer MD, Davies P, Graziano D, Thurber AE, Kaplan DL. Neural circuits with long-distance axon tracks for determining functional connectivity J. Neuroscience Methods 8:222C:82-90 (2014) [PMID 242161777] Vasudev MC, Koerner H, Singh KM, Partlow BP, Kaplan DL, Gazit E, Bunning TJ, Naik RR. Vertically aligned peptide nanostructures using plasma-enhanced chemical vapour deposition. Biomacromolecules, 15(2): 533-540 (2014) [PMID 24400716] Wu J, Rnjak-Kovacina J, Du Y, Funderburgh ML, Kaplan DL, Funderburgh JL. Corneal stromal bioequivalents secreted on patterned silk substrates. Biomaterials 35(12): 3744-3755 (2014) [PMID 24503156] Xia, XX, Wang M, Lin Y, Xu Q, Kaplan DL. Hydrophobic drug-triggered self-assembly of nanoparticles from silkelastin-like protein polymers for drug delivery. Biomacromolecules, Feb 21, ahead of print (2014) [PMID 24527851] Zhang W, Zhu C, Wu Y, Ye D, Wang S, Zou D, Zhang X, Kaplan DL, Jiang X. VEGF and BMEP-2 promote bone regeneration by facilitating bone marrow stem cell homing and differentiation. European Cell Materials 127:1-12 (2014) [PMID 24425156]