王炜 - 南京大学 - 物理学院

个人简介

物理学院教授（1992年），博士生导师（1995年），长江计划教授（1999年度，理论物理），南京大学生物物理研究所所长。1996年度获国家杰出青年基金，1997年获香港求是基金会-杰出青年研究奖(物理学)，科技部973项目“非线性科学及其重要应用”首席科学家（2007-2011），科技部973项目“与激光聚变、自然灾害和深空探测等相关的非线性动力学斑图和轨道稳定性研究”首席科学家（2013-2017）。现任美国《Proteins》等杂志编委。在Nature Struct. Biol.、PNAS、PRL和JACS等期刊上发表学术论文200余篇。2010年获教育部自然科学成果奖一等奖。

研究领域

凝聚态物理与生物交叉学科研究：蛋白质折叠、聚集动力学以及复杂相互作用下生物分子组装微结构特性；生物网络系统信息过程的物理机制和动力学特性。

近期论文

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Wenxu Sun, Bin Xue, Qiyang Fan, Runhan Tao, Chunxi Wang, Xin Wang, Yiran Li, Meng Qin, Wei Wang*, Bin Chen* and Yi Cao* (2020) Molecular engineering of metal coordination interactions for strong, tough, and fast-recovery hydrogels. Sci. Adv. 6 (16), eaaz9531. Hai Lei, Liang Dong, Ying Li, Junsheng Zhang, Huiyan Chen, Junhua Wu, Yu Zhang, Qiyang Fan, Bin Xue, Meng Qin, Bin Chen, Yi Cao* and Wei Wang (2020) Stretchable hydrogels with low hysteresis and antifatigue fracture based on polyprotein cross-linkers. Nat. Commun. 11, 4032. Wenfei Li*, Jun Wang, Jian Zhang, Shoji Takada* and Wei Wang* (2019) Overcoming the bottleneck of the enzymatic cycle by steric frustration. Phys. Rev. Lett. 122 (23), 238102. Weishuai Di, Xiang Gao, Wenmao Huang, Yang Sun, Hai Lei, Yang Liu, Wenfei Li, Yiran Li, Xin Wang, Meng Qin, Zhenshu Zhu, Yi Cao* and Wei Wang* (2019) Direct measurement of length scale dependence of hydrophobic free energy of a single collapsed polymer nanosphere. Phys. Rev. Lett. 122 (4), 047801. Wenmao Huang, Xin Wu, Xiang Gao, Yifei Yu, Hai Lei, Zhenshu Zhu, Yi Shi, Yulan Chen, Meng Qin, Wei Wang* and Yi Cao* (2019) Maleimide-thiol adducts stabilized through strctching. Nat. Chem. 11 (4), 310-319. Ruiheng Song, Xialian Wu, Bin Xue, Yuqin Yang, Wenmao Huang, Guixiang Zeng, Jian Wang, Wenfei Li, Yi Cao, Wei Wang*, Junxia Lu* and Hao Dong* (2019) Principles governing catalytic activity of self-assembled short peptides. J. Am. Chem. Soc. 141 (23), 223-231. Yaolai Wang, Tongfei Ni, Wei Wang* and F. Liu* (2019) Gene transcription in bursting: a uniﬁed mode for realizing accuracy and stochasticity. Biol. Rev. 94 (1), 248-258. Junhua Wu, Pengfei Li, Chenli Dong, Heting Jiang, Bin Xue, Xiang Gao, Meng Qin, Wei Wang*, Bin Chen* and Y Cao* (2018) Rationally designed synthetic protein hydrogels with predictable mechanical properties. Nat. Commun. 9, 620. Qianyuan Tang, Yangyang Zhang, Jun Wang*, Wei Wang* and D. R. Chialvo* (2017) Critical fluctuations in the native state of proteins. Phys. Rev. Lett. 118 (8), 088102. Jun Zhou*, S. Amrane, F. Rosu, G. F. Salgado, Yuanqiang Bian, H. Tateishi-Karimata, E. Largy, D. N. Korkut, A. Bourdoncle, D. Miyoshi, Jian Zhang, Huangxian Ju, Wei Wang*, N. Sugimoto, V. Gabelica, and J. L. Mergny* (2017) Unexpected position-dependent effects of ribose G-Quartets in G-Quadruplexes. J. Am. Chem. Soc. 139 (23), 7768- 7779. Yang Sun, Weishuai Di, Yiran Li, Wenmao Huang, Xin Wang, Meng Qin, Wei Wang* and Yi Cao*(2017) Mg2+-dependent high mechanical anisotropy of three-way-junction pRNA as revealed by single-molecule force spectroscopy. Angew. Chem.-Intern. Edit. 56 1(32), 9376-9380. Xinyu Tian, Bo Huang, Xiaopeng Zhang, Mingyang Lu, Feng Liu*, Jose N. Onuchic*, and Wei Wang* (2017) Modeling the response of a tumor-suppressive network to mitogenic and oncogenic signals. Proc. Natl. Acad. Sci. USA 114 (21), 5337-5342. Yaolai Wang, Feng Liu* and Wei Wang* (2016) Kinetics of transcription initiation directed by multiple cis-regulatory elements on the glnAp2 promoter. Nucleic Acids Res. 44 (22), 10530-10538. Meng Qin, Wei Wang* and Dave Thirumalai* (2015) Protein folding guides disulfide bond formation. Proc. Natl. Acad. Sci. USA 112 (36), 11241-11246. Wenfei Li, Jun Wang*, Jian Zhang and Wei Wang* (2015) Molecular simulations of metal-coupled protein folding. Curr. Opin. Struct. Biol. 30, 25-31. Chunmei Lv, Xiang Gao, Wenfei Li, Bo Xue, Meng Qin, Leslie D. Burtnick, Hao Zhou, Yi Cao*, Robert C. Robinson* and Wei Wang* (2014) Single-molecule force spectroscopy reveals force-enhanced binding of calcium ions by gelsolin. Nat. Commun. 5, 4623. Wenfei Li, Wei Wang* and Shoji Takada* (2014) Energy landscape views for interplays among folding, binding, and allostery of calmodulin domains. Proc. Natl. Acad. Sci. USA 111 (29), 10550-10555. Wenfei Li, Tsuyoshi Terakawa, Wei Wang* and Shoji Takada* (2012) Energy landscape and multiroute folding of topologically complex proteins adenylate kinase and 2ouf-knot. Proc. Natl. Acad. Sci. USA 109 (44), 17789-17794. Xiao-Peng Zhang, Feng Liu*, Zhang Cheng and Wei Wang* (2011) Cell fate decision mediated by p53 pulses. Proc. Natl. Acad. Sci. USA 106 (30), 12245-12250 Yujie Zhang, Jian Zhang* and Wei Wang* (2011) Atomistic analysis of pseudoknotted RNA Unfolding. J. Am. Chem. Soc. 133 (18), 6882-6885.