Wu, Yaowen - Umeå University, Umeå, Sweden

研究领域

Our lab is interested in understanding the molecular mechanism of autophagy and membrane trafficking regulated by small GTPases by developing novel chemical and chemo-optogenetic approaches.

近期论文

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Synthesis of 20-Membered Macrocyclic Pseudo-Natural Products Yields Inducers of LC3 Lipidation Angewandte Chemie International Edition Niggemeyer, Georg; Knyazeva, Anastasia; Gasper, Raphael; et al. Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin Cell Chemical Biology, Elsevier 2021, Vol. 28, (12) : 1750-1757.e5 Carnero Corrales, Marjorie A.; Zinken, Sarah; Konstantinidis, Georgios; et al. Vibrio cholerae cytotoxin MakA induces noncanonical autophagy resulting in the spatial inhibition of canonical autophagy Journal of Cell Science, The Company of Biologists 2021, Vol. 134, (5) Corkery, Dale; Nadeem, Aftab; Aung, Kyaw Min; et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Autophagy, Taylor & Francis 2021, Vol. 17, (1) : 1-382 Corkery, Dale; Wu, Yao-Wen; Dowaidar, Moataz Monitoring the Response of Multiple Signal Network Components to Acute Chemo-Optogenetic Perturbations in Living Cellsope ChemBioChem (Print) Kowalczyk, Manuela; Kamps, Dominic; Wu, Yao-Wen; et al. Imaging of spatial cycling of Rab GTPase in the cell Rab GTPases: methods and protocols, Humana Press 2021 : 105-115 Li, Fu; Wu, Yao-Wen RAB33B recruits the ATG16L1 complex to the phagophore via a noncanonical RAB binding protein Autophagy, Taylor & Francis 2021, Vol. 17, (9) : 2290-2304 Pantoom, Supansa; Konstantinidis, Georgios; Voss, Stephanie; et al. Spatiotemporal Imaging of Small GTPase Activity Using Conformational Sensors for GTPase Activity (COSGA) Ras Activity and Signaling: Methods and Protocols, Humana Press 2021 : 259-267 Wu, Yao-Wen Phenotyping Reveals Targets of a Pseudo-Natural-Product Autophagy Inhibitor Angewandte Chemie International Edition, Wiley-VCH Verlagsgesellschaft 2020, Vol. 59, (30) Foley, Daniel J.; Zinken, Sarah; Corkery, Dale; et al. Optogenetic Tuning Reveals Rho Amplification-Dependent Dynamics of a Cell Contraction Signal Network Cell reports, Cell Press 2020, Vol. 33, (9) Kamps, Dominic; Koch, Johannes; Juma, Victor O.; et al. Image-Based Morphological Profiling Identifies a Lysosomotropic, Iron-Sequestering Autophagy Inhibitor Angewandte Chemie International Edition, Wiley-VCH Verlagsgesellschaft 2020, Vol. 59 : 5721-5729 Laraia, Luca; Garivet, Guillaume; Foley, Daniel J.; et al. Inhibition of K-Ras4B-plasma membrane association with a membrane microdomain-targeting peptide Chemical Science, Royal Society of Chemistry 2020, Vol. 11, (3) : 826-832 Li, Fang-Yi; Zhang, Zhen-Feng; Voss, Stephanie; et al. Distinct Mechanisms for Processing Autophagy Protein LC3-PE by RavZ and ATG4B ChemBioChem (Print), Wiley-VCH Verlagsgesellschaft 2020, Vol. 21, (23) : 3377-3382 Yang, Aimin; Pantoom, Supansa; Wu, Yao-Wen Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology eLIFE, ELIFE SCIENCES PUBLICATIONS LTD 2019, Vol. 8 Alex, Amal; Piano, Valentina; Polley, Soumitra; et al. Modulation of autophagy by the novel mitochondrial complex I inhibitor Authipyrin Bioorganic & Medicinal Chemistry, Vol. 27, (12) : 2444-2448 Kaiser, Nadine; Corkery, Dale; Wu, Yao-Wen; et al. Light-Induced Dimerization Approaches to Control Cellular Processes Chemistry - A European Journal, Vol. 25 : 12452-12463 Klewer, Laura; Wu, Yao-Wen The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis Nature Chemical Biology, Nature Publishing Group 2019, Vol. 15, (7) : 710-720 Laraia, Luca; Friese, Alexandra; Corkery, Dale; et al. Spatial Cycling of Rab GTPase, Driven by the GTPase Cycle, Controls Rab's Subcellular Distribution Biochemistry, American Chemical Society (ACS) 2019, Vol. 58, (4) : 276-285 Voss, Stephanie; Li, Fu; Raetz, Andreas; et al. Bacterial interaction with host autophagy Virulence, Vol. 10, (1) : 352-362 Wu, Yao-Wen; Li, Fu Toward the role of cholesterol and cholesterol transfer protein in autophagosome biogenesis Autophagy, Taylor & Francis Group 2019, Vol. 15, (12) : 2167-2168 Wu, Yao-Wen; Waldmann, Herbert