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Comprehensive Insights into the Catalytic Mechanism of Middle East Respiratory Syndrome 3C-Like Protease and Severe Acute Respiratory Syndrome 3C-Like Protease. Hao Wang, Shuai He, Weilong Deng, Ying Zhang, Guobang Li, Jixue Sun, Wei Zhao, Yu Guo, Zheng Yin, Dongmei Li*, and Luqing Shang*.ACS Catalysis 2020, 10, 10, 5871-5890.
Establishment of a Customizable Fluorescent Probe Platform for the Organelle-Targeted Bioactive Species Detection. Dan Qiao, Landie Li, Tangliang Shen, Jiejie Yang, Hao Chang, Xiao Liang, Lu Zhang, Qianqian Wang, Ning Liu, Wei Zhao, and Luqing Shang*.ACS Sens. 2020, 5, 7, 2247-2254.
Application of dually activated Michael acceptor to the rational design of reversible covalent inhibitor for Enterovirus 71 3C protease. Yuying Ma, Linfeng Li, Shuai He, Chengyou Shang, Yang Sun, Ning Liu, Thomas Meek, Ya Xin Wang*,Luqing Shang*. J. Med. Chem., 2019, 62, 6146-6162.
An ICT-based mitochondria-targeted fluorescent probe for hydrogen peroxide with a large turn-on fluorescence signal. Xiao Liang, Lu Zhang, Xiaoyi Xu, Dan Qiao, Tangliang Shen, Zheng Yin,Luqing Shang*. ChemistrySelect, 2019, 4(4), 1330-1336.
4‐Iminooxazolidin-2-one as a bioisostere of the cyanohydrin moiety: inhibitors of enterovirus 71 3C protease. Yuying Ma, Chengyou Shang, Peng Yang, Linfeng Li, Yangyang Zhai, Zheng Yin, Binghe Wang*,Luqing Shang*. J. Med. Chem., 2018, 61, 22, 10333-10339.
A highly selective and sensitive fluorescent probe for simultaneously distinguishing and sequentially detecting H2S and various thiol species in solution and in live cells. Dan Qiao, Tangliang Shen, Mengyuan Zhu, Xiao Liang, Lu Zhang, Zheng Yin, Binghe Wang*,Luqing Shang*. Chem. Commun., 2018, 54, 13252-13255.
3D-quantitative structure-activity relationship study for the design of novel。enterovirus A71 3C protease inhibitors. Quandeng Nie, Xiaoyi Xu, Qi Zhang, Yuying Ma, Zheng Yin,Luqing Shang*. Chem Biol Drug Des. 2018, 92(4), 1750-1762.
Target-guided screening of fragments (TGSOF) in the discovery of inhibitors against EV-A71 3C protease. Shengjun Fu, Quandeng Nie, Yuying Ma, Ping Song, Xuejiao Ren, Cheng Luo,Luqing Shang*, Zheng Yin*. Chem. Commun.,2018, 54, 2890-2893.
Dual mechanism ICT-FRET-based fluorescent probe for the selective detection of hydrogen peroxide. Xiao Liang, Xiaoyi Xu, Dan Qiao, Zheng Yin, Luqing Shang*. Chem-Asian J. 2017, 2017,12, 3187-3194.
Structure of the Enterovirus 71 3C protease in complex with NK-1.8k and indications for the development of antienterovirus protease inhibitor. Yaxin Wang, Lin Cao, Yangyang Zhai, Zheng Yin, Yuna Sun*,Luqing Shang*. Antimicrob. Agents. Chemother. 2017, 61, e00298-17.
Inhibition of enterovirus 71 replication by ana-hydroxy-nitrile derivative NK-1.9k. Yaxin Wang, Lin Cao, Yangyang Zhai, Jiaming Ma, Quandeng Nie, Ting Li, Zheng Yin, Yuna Sun*,Luqing Shang*. Antiviral Res. 2017, 141, 91-100.
Discovery of 2’-a-C-Methyl-2’-b-C-fluorouridine phosphoramidate prodrugs as inhibitors of Hepatitis C virus. Debin Zeng, Rui Zhang, Quandeng Nie, Lin Cao,Luqing Shang*, Zheng Yin* ACS Med. Chem. Lett. 2016, 7 (12), 1197-1201
Structure activity relationship study of peptidomimetic aldehydes as enterovirus 71 3C protease inhibitors. Yangyang Zhai, Yuying Ma, Fei Ma, Quandeng Nie, Xuejiao Ren, Yaxin Wang,Luqing Shang*, Zheng Yin*. Eur. J. Med. Chem. 2016, 124: 559-573.
A 3,7-dihydroxyphenoxazine-based fluorescent probe for selective detection of intracellular hydrogen peroxide. Zhiqiang Han Xiao Liang, Xuejiao RenLuqing Shang*, Zheng Yin*. Chem-Asian J. 2016, 11: 818-822.
Synthesis and structure–activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors. Debin Zeng, Yuying Ma, Rui Zhang, Quandeng Nie, Zhengjie Cui, Yaxin Wang,Luqing Shang*, Zheng Yin*. Bioorg.Med.Chem. Lett., 2016, 26 (7):1762-1766.
The discovery of indole derivatives as novel hepatitis C virus inhibitors.Zhiqiang Han, Xiao Liang, Yaxin Wang, Jie Qing, Lin Cao,Luqing Shang*, Zheng Yin*. Euro. J. Med. Chem., 2016, 116: 147-155.
Cyanohydrin as an anchoring group for potent and selective inhibitors of Enterovirus 71 3C protease. Yangyang Zhai, Xiangshuai Zhao, Zhengjie Cui, Man Wang, Yaxin Wang, Linfeng Li, Qi Sun, Xi Yang, Debing Zeng, Ying Liu, Yuna Sun, Zhiyong Lou,Luqing Shang*, Zheng Yin*, J. Med. Chem., 2015,58,941-9420.
Site-specific chemical modification of peptide and protein by thiazolidinediones. Peng Wang,Shumei Zhang,Qiuyue Meng,Ying Liu,Luqing Shang*, andZheng Yin*,Org. Lett., 2015, 17 (6), 1361–1364.
Biochemical characterization of recombinant Enterovirus 71 3C protease with fluorogenic model peptide substrates and development of a biochemical assay.Luqing Shang, Shumei Zhang, Xi Yang, Jixue Sun, Linfeng Li, Zhengjie Cui, Qiuhong He, Yu Guo, Yuna Sun*, Zheng Yin*, Antimicrob. Agents. Chemother., 2015 Apr; 59(4):1827-1836.