刘天罡 - 武汉大学

个人简介

教育经历 2002年- 2008年上海交通大学生命科学技术学院，博士 2006年- 2007年美国布朗大学化学系，博士生联合培养 1998年- 2002年山东大学生命科学学院，本科工作经历 2021年-至今武汉大学药学院，教授二级、博导 2015年-2021 武汉大学药学院，教授三级、博导 2012年-至今合成微生物技术湖北省工程实验室，主任武汉生物技术研究院，副总工程师 2010年-2015年武汉大学药学院，教授四级、博导 2008年-2010年美国斯坦福大学化学系，博士后

研究领域

1. 改造微生物代谢途径高效合成抗生素维生素等天然产物 2. 利用合成生物学生产稀有来源药物和药物前体 3. 高通量挖掘微生物天然产物

近期论文

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Chen R, Jia Q, Mu X, Hu B, Sun X, Deng Z, Chen F*, Bian G*, Liu T*. Systematic mining of fungal chimeric terpene synthases using an efficient precursor-providing yeast chassis. Proc Natl Acad Sci U S A. Accepted Hu B#, Liu R#, Tang X#, Pan Y#, Wang M#, Tong Y#, Ye G#, Shen G#, Ying R#, Fu A, Li D, Zhao W, Peng J, Guo J, Men D, Yao X, Wang Y, Zhang H, Feng Z, Yu J, Chen L, Deng Z, Lu X, Zhang Y*, Li Y*, Liu B*, Yu L*, Li Y*, Lu J*, Liu T*. 2021. The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants, National Science Review, nwab073, https://doi.org/10.1093/nsr/nwab073 He H#, Bian G#, Herbst-Gervasoni C#, Mori T, Shinsky S, Hou A, Mu X, Huang M, Cheng S, Deng Z, Christianson D*, Abe I*, Liu T*. 2020. Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases. Nature Communication, 11:3958 Liu R, Zhang Y, Zhai G, Fu S, Xia Y, Hu B, Cai X, Zhang Y, Li Y, Deng Z, Liu T*. 2020. A cell-free platform based on nisin biosynthesis for discovering novel lanthipeptides and guiding their overproduction in vivo. Advanced Science, 202001616 Wang M#, Fu A#, Hu B#, Tong Y#, Liu R#, Liu Z, Gu J, Xiang B, Liu J, Jiang W, Shen G, Zhao W, Men D, Deng Z, Yu L, Wei W*, Li Y*, Liu T*. 2020. Nanopore targeted sequencing for the accurate and comprehensive detection of SARS-CoV-2 and other respiratory viruses. Small, 2002169 Siemon T#, Wang Z#, Bian G#, Seitz T, Ye Z, Lu Y, Liu T*, Mathias C*. 2020.　 Semisynthesis of plant-derived englerin A enabled by microbe engineering of guaia-6, 10 (14)-diene as building block. Journal of the American Chemical Society. 142(6): 2760-2765 Kang W#, Ma T#, Liu M, Qu Z, Liu Z, Zhang H, Shi B, Fu S, Ma J, Lai L, He S, Qu J, Au S, Kang B, Lau W, Deng Z, Xia J*, Liu T*. 2019. Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux. Nature Communications. 10: 4248. Shi B, Ma T, Ye Z, Li X, Huang Y, Zhou Z, Ding Y, Deng Z, Liu T*.2019. Systematic metabolic engineering of saccharomyces cerevisiae for lycopene overproduction. Journal of Agricultural and Food Chemistry, 67:11148-11157 Ma T#, Shi B, Ye Z, Li X, Liu M, Chen Y, Xia J, Jens N, Deng ZX, Liu T*. 2019. Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene. Metabolic Engineering, 52: 134-142. Bian G#, Rinkel J#, Wang Z, Lauterbach L, Hou A, Yuan Y, Deng Z, Liu T*, Dickschat JS*. 2018. A Clade II-D Fungal Chimeric Diterpene Synthase from Colletotrichum gloeosporioides Making Dolasta-1(15), 8-diene. Angew Chem Int Ed Engl, 57:15887-15890. Mary A#, Zhang Y#, Whitney H, Wang G, Baidoo E, Liu T*, Tang Y*. 2018. Comparative Studies of Glycolytic Pathways and Channeling Under in Vitro and in Vivo Modes. AIChE Journal. doi 10.1002 / aic.16367. Liu R#, Deng Z, Liu T*. 2018. Streptomyces species: Ideal chassis for natural product discovery and over production. Metabolic Engineering, 50: 74–84. Ding J#, Liang H, Fu S, Liu R, Deng Z, Liu T*. 2018. Modification of E-Poly-L-Lysine In Vivo to Reduce Self-Toxicity and Enhance Antibiotic Overproduction. AIChE Journal, 64(12):4187-4192. Bian G#, Hou A, Yuan Y, Hu B, Cheng S, Ye Z, Di Y, Deng Z, Liu T*. 2018. Metabolic engineering-based rapid characterization of a sesquiterpene cyclase and the skeletons of fusariumdiene and fusagramineol from Fusarium graminearum. Organic Letters, 20(6): 1626-1629. Bian G#, Deng Z, Liu T*. 2017. Strategies for terpenoid overproduction and new terpenoid discovery. Current Opinion in Biotechnology, 48:234–241. Bian G#, Han Y, Hou A, Yuan Y, Liu X, Deng Z, Liu T*. 2017. Releasing the potential power of terpene synthases by a robust precursor supply platform. Metabolic Engineering, 42:1-8. Tan G#, Deng K, Liu X, Tao H, Chang Y, Chen J, Chen K, Sheng Z, Deng Z, Liu T*. 2017. Heterologous Biosynthesis of Spinosad: An Omics-Guided Large Polyketide Synthase Gene Cluster Reconstitution in Streptomyces. ACS Synthetic Biology, 6(6):995-1005 Liu Z#, Zhang Y#, Jia X, Hu M, Deng Z, Xu Y*, Liu T*. 2017. In Vitro Reconstitution and Optimization of the Entire Pathway to Convert Glucose into Fatty Acid. ACS Synthetic Biology, 6(4):701-709 Tan G#, Liu T*. 2017. Rational synthetic pathway refactoring of natural products biosynthesis in actinobacteria. Metabolic Engineering, 39: 228-236.