个人简介

Dr. Read de Alaniz received his B.S. degree from Fort Lewis College in 1999 and his Doctoral Degree from Colorado State University in 2006. His doctoral training under the direction of Professor Tomislav Rovis focused on asymmetric catalysis using N-heterocyclic carbenes. He pursued his postdoctoral studies at the University of California, Irvine where he worked in the area of total synthesis with Professor Larry E. Overman. During that time he was the recipient of the University of California President’s Postdoctoral Fellowship. Dr. Read de Alaniz joined the faculty at UCSB in 2009.

研究领域

Organic & Bioorganic/Molecular Design & Synthesis/Energy/Catalysis & Green Chemistry

Research in the Read de Alaniz group focuses on new reaction developments and their application to the synthesis of architecturally challenging and biologically important molecules. Our main focus is identifying efficient new methods for the efficient construction of carbon–nitrogen bonds. Nitrogen-functionalized molecules are valuable pharmaceutical targets and fundamental building blocks in natural product synthesis.

近期论文

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“High strain-rate response of spiropyran mechanophores in PMMA” Hemmer, J. R.; Smith, P. D.; van Horn, M.; Alnemrat, S.; Mason, B. P.; Read de Alaniz, J.; Osswald, S.; Hooper, J. P. J. Polym. Sci. B. Polym. Phys. doi: 10.1002/polb.23569. “Nitrosocarbonyl Hetero-Diels–Alder Cycloaddition: A New Tool for Conjugation” Samoshin, A. V.; Hawker, C. J., Read de Alaniz,* J. ACS Macro Lett. 2014, 3, 753-757. “Controlled Radical Polymerization of Acrylates Regulated by Visible Light” Treat, N. J.; Fors, B. P.; Kramer, J. W.; Christianson, M.; Chiu, C.-Y.; Read de Alaniz, J.; Hawker,* C. J. ACS Marco Lett. 2014, 3, 580-584. “Photoswitching Using Visible Light: A New Class of Organic Photochromic Molecules” Helmy, S.; Leibfarth, F. A.; Oh, S.; Poelma, J. E.; Hawker, C. J.; Read de Alaniz,* J. J. Am. Chem. Soc. 2014, 136, 8169-8172. “Efficient synthesis of 4-hydroxycyclopentenones: dysprosium(III) triflate catalyzed Piancatelli rearrangement” Fisher, D.; Palmer, L. I.; Cook, J. E.; Davis, J. E.; Read de Alaniz,* J. Tetrahedron 2014, 70, 4105-4110. “Developments in Nitrosocarbonyl Chemistry: Mild Oxidation of N-Substituted Hydroxylamines Leads to New Discoveries” Palmer, L. I.; Frazier, C. P.; Read de Alaniz,* J. Synthesis 2014, 46, 269-280. “Lewis Acid Catalyzed Rearrangement of Furylcarbinols: The Aza- and Oxa-Piancatelli Cascade Reaction” Palmer, L. I.; Read de Alaniz,* J. Synlett 2014, 25, 8-11. “Importance of Off-Cycle Species in the Acid-Catalyzed Aza-Piancatelli Rearrangement” Yu, D.;Thai, V. T.; Palmer, L. I.; Veits, G. K.; Read de Alaniz, J.; Hein,* J. E. J. Org. Chem. 2013, 78, 12784-12789. “Rapid Synthesis of Fused Oxabicycles through the Molecular Rearrangement of Spirocyclic Ethers” Palmer, L. I.; Veits, G. K.; Read de Alaniz,* J. Eur. J. Org. Chem. 2013. DOI: 10.1002/ejoc.201300832. “Electrophilic α-oxygenation reaction of β-ketoesters using N-hydroxycarbamates: control of the ambident reactivity of nitrosoformate intermediates” Frazier, C. P.; Sandoval, D.; Palmer, L. I.; Read de Alaniz,* J. Chem. Sci. 2013, 4, 3857. “Aza-Piancatelli Rearrangement Initiated by Ring Opening of Donor–Acceptor Cyclopropanes” Wenz, D. R.; Read de Alaniz,* J. Org. Lett. 2013, 15, 3250. “Rapid and Stereoselective Synthesis of Spirocyclic Ethers via the Intramolecular Piancatelli Rearrangement” Palmer, L. I.; Read de Alaniz,* J. Org. Lett. 2013, 15, 476. “Electrophilic α‑Amination Reaction of β‑Ketoesters Using N‑Hydroxycarbamates: Merging Aerobic Oxidation and Lewis Acid Catalysis” Sandoval, D.; Frazier, C. P.; Bugarin, A.; Read de Alaniz,* J. J. Am. Chem. Soc. 2012, 134, 18948. “Copper-Catalyzed Aerobic Oxidation of N-Substituted Hydroxylamines: Efficient and Practical Access to Nitroso Compounds.” Frazier, C. P.; Bugarin, A.; Engelking, J. R.; Read de Alaniz,* J. Org. Lett. 2012, 14, 3620. “Dysprosium(III) Catalysis in Organic Synthesis.” Veits, G. K.; Read de Alaniz,* J. Tetrahedron 2012, 68, 2015. “Direct and Highly Diastereoselective Synthesis of Azaspirocycles by a Dysprosium(III) Triflate Catalyzed Aza-Piancatelli Rearrangement.” Palmer, L. I.; Read de Alaniz,* J. Angew. Chem. Int. Ed. 2011, 50,7167. “Copper-Catalyzed Aerobic Oxidation of Hydroxamic Acids Leads to a Mild and Versatile Acylnitroso Ene Reaction.” Frazier, C, P.; Engelking, J. R.; Read de Alaniz,* J. J. Am. Chem. Soc. 2011, 133, 10430–10433. “A Versatile Method for Synthesis of 4-Aminocyclopentenones via a Dysprosium (III) Triflate-Catalyzed Aza-Piancatelli Rearrangement.” Veits, G. K.; Wenz, D. R.; Read de Alaniz,* J. Angew. Chem. Int. Ed. 2010, 49, 9484–9487. “Total Synthesis of (+)-Nankakurine A and B and ()-5-epi-Nankakurine A.” Altaman, R. A.; Nilsson, B. L.; Overman,* L. E.; Read de Alaniz, J.; Rohde, J. M.; Taupin, V. J. Org. Chem. 2010, 75, 7519–7534. “ Preparation of Chiral and Achiral Triazolium Salts: Carbene Precursors with Demonstrated Synthetic Utility.” Vora, H. U.; Lathrop, S. P.; Reynolds, N. T.; Kerr, M. S.; Read de Alaniz, J.; Rovis,* T. Org. Synth. 2010, 87, 350–361.