Jia, Xinying - The University of Queensland - Centre for Advanced Imaging

个人简介

The rise of antibiotic resistance is an increasingly serious threat in every corner of the world. The development of new antibiotics, especially with new modes of action, is imperative to treat microbial-caused infectious disease. Transcription factor NusA is highly conserved, unique and indispensable to bacteria, but transcription is an underutilised target in antibiotic development and there is not an antibiotic acting on NusA. Therefore the development of lead molecules inhibiting NusA activity represents a promising opportunity to develop a new class of antibiotics. We aim to design a new class of antibiotics specifically targeting the interaction of the essential transcription factor NusA and its binding region on RNA polymerase. This research will provide the first high-resolution structure of the interaction of bacterial RNA polymerase with the essential transcription factor NusA, and will guide development of lead molecules for drug design.

研究领域

The structural biology theme at CAI is focused on the study of biomolecules using magnetic resonance based methods. In particular projects focus on the structure and function of proteins in solution. This involves the use of advanced multidimensional solution state NMR experiments, with in-house expertise in all areas from protein production and pulse sequence design to signal processing and structure calculation.

近期论文

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Miljenovic, Tomas Marko, Jia, Xinying and Mobli, Mehdi (2018). Nonuniform sampling in biomolecular NMR. In Modern Magnetic Resonance (pp. 2035-2054) Cham, Switzerland: Springer International Publishing. doi:10.1007/978-3-319-28388-3_118 Tian, Wenya, Sun, Chenghai, Zheng, Mei, Harmer, Jeffrey R., Yu, Mingjia, Zhang, Yanan, Peng, Haidong, Zhu, Dongqing, Deng, Zixin, Chen, Shi-Lu, Mobli, Mehdi, Jia, Xinying and Qu, Xudong (2018) Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids. Nature Communications, 9 1: 4428. doi:10.1038/s41467-018-06528-z Zhang, Alan H., Sharma, Gagan, Undheim, Eivind A. B., Jia, Xinying and Mobli, Mehdi (2018) A complicated complex: ion channels, voltage sensing, cell membranes and peptide inhibitors. Neuroscience Letters, 679 35-47. doi:10.1016/j.neulet.2018.04.030 Tabassum, Nargis, Tae, Han-Shen, Jia, Xinying, Kaas, Quentin, Jiang, Tao, Adams, David J. and Yu, Rilei (2017) Role of CysI–CysIII disulfide bond on the structure and activity of α-conotoxins at human neuronal nicotinic acetylcholine receptors. ACS Omega, 2 8: 4621-4631. doi:10.1021/acsomega.7b00639 Zhang, Benyin, Tian, Wenya, Wang, Shuwen, Yan, Xiaoli, Jia, Xinying, Pierens, Gregory K., Chen, Wenqing, Ma, Hongmin, Deng, Zixin and Qu, Xudong (2017) Activation of natural products biosynthetic pathways via a protein modification level regulation. ACS Chemical Biology, 12 7: 1732-1736. doi:10.1021/acschembio.7b00225 Laohaviroj, Marut, Potriquet, Jeremy, Jia, Xinying, Suttiprapa, Sutas, Chamgramol, Yaovalux, Pairojkul, Chawalit , Sithithaworn, Paiboon, Mulvenna, Jason and Sripa, Banchob (2017) A comparative proteomic analysis of bile for biomarkers of cholangiocarcinoma. Tumor Biology, 39 6: 1010428317705764. doi:10.1177/1010428317705764 Miljenović, Tomas, Jia, Xinying, Lavrencic, Peter, Kobe, Bostjan and Mobli, Mehdi (2017) A non-uniform sampling approach enables studies of dilute and unstable proteins. Journal of Biomolecular NMR, 68 2: 1-9. doi:10.1007/s10858-017-0091-z Kumar, Dhirendra, Yadav, Amit Kumar, Jia, Xinying, Mulvenna, Jason and Dash, Debasis (2016) Integrated transcriptomic-proteomic analysis using a proteogenomic workflow refines rat genome annotation. Molecular and Cellular Proteomics, 15 1: 329-339. doi:10.1074/mcp.M114.047126 Yu, Rilei, Seymour, Victoria A. L., Berecki, Geza, Jia, Xinying, Akcan, Muharrem, Adams, David J., Kaas, Quentin and Craik, David J. (2015) Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Scientific Reports, 5 Art No.: 13264: . doi:10.1038/srep13264 Brinkman, Diane L., Jia, Xinying, Potriquet, Jeremy, Kumar, Dhirendra, Dash, Debasis, Kvaskoff, David and Mulvenna, Jason (2015) Transcriptome and venom proteome of the box jellyfish Chironex fleckeri. BMC Genomics, 16 1: 407-407. doi:10.1186/s12864-015-1568-3 Plieskatt, Jordan, Rinaldi, Gabriel, Feng, Yanjun, Peng, Jin, Easley, Samantha, Jia, Xinying, Potriquet, Jeremy, Pairojkul, Chawalit, Bhudhisawasdi, Vajarabhongsa, Sripa, Banchob, Brindley, Paul J, Bethony, Jeffrey and Mulvenna, Jason (2015) A microRNA profile associated with Opisthorchis viverrini-induced cholangiocarcinoma in tissue and plasma. BMC Cancer, 15 309: 1-15. doi:10.1186/s12885-015-1270-5 Tian, Zhenhua, Sun, Peng, Yan, Yan, Wu, Zhuhua, Zheng, Qingfei, Zhou, Shuaixiang, Zhang, Hua, Yu, Futao, Jia, Xinying, Chen, Dandan, Mandi, Attila, Kurtan, Tibor and Liu, Wen (2015) An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins. Nature Chemical Biology, 11 4: 259-265. doi:10.1038/nchembio.1769 Plieskatt, Jordan, Rinaldi, Gabriel, Brindley, Paul J., Jia, Xinying, Potriquet, Jeremy, Bethony, Jeffrey and Mulvenna, Jason (2014) Bioclojure: a functional library for the manipulation of biological sequences. Bioinformatics, 30 17: 2537-2539. doi:10.1093/bioinformatics/btu311 Jia, Xinying, Schulte, Leigh, Loukas, Alex, Pickering, Darren, Pearson, Mark, Mobli, Mehdi, Jones, Alun, Rosengren, Karl J., Daly, Norelle L., Gobert, Geoffrey N., Jones, Malcolm K., Craik, David J. and Mulvenna, Jason (2014) Solution structure, membrane interactions and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni. Journal of Biological Chemistry, 289 10: 1-26. doi:10.1074/jbc.M113.531558 Jia, Xinying, Kwon, Soohyun, Wang, Ching-I Anderson, Huang, Yen-Hua, Chan, Lai Y., Tan, Chia Chia, Rosengren, K. Johan, Mulvenna, Jason P., Schroeder, Christina I. and Craik, David J. (2014) Semienzymatic cyclization of disulfide-rich peptides using sortase A. Journal of Biological Chemistry, Papers in Press 10: 1-25. doi:10.1074/jbc.M113.539262 Jaudzems, Kristaps, Jia, Xinying, Yagi, Hiromasa, Zhulenkovs, Dmitry, Graham, Bim, Otting, Gottfried and Liepinsh, Edvards (2012) Structural basis for 5′-end-specific recognition of single-stranded DNA by the R3H domain from human Sμbp-2. Journal of Molecular Biology, 424 1-2: 42-53. doi:10.1016/j.jmb.2012.09.010 Graham, Bim, Loh, Choy Theng, Swarbrick, James David, Ung, Phuc, Shin, James, Yagi, Hiromasa, Jia, Xinying, Chhabra, Sandeep, Barlow, Nicholas, Pintacuda, Guido, Huber, Thomas and Otting, Gottfried (2011) DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra. Bioconjugate Chemistry, 22 10: 2118-2125. doi:10.1021/bc200353c Jia, Xinying, Yagi, Hiromasa, Su, Xun-Cheng, Stanton-Cook, Mitchell, Huber, Thomas and Otting, Gottfried (2011) Engineering [Ln(DPA)3]3- binding sites in proteins: a widely applicable method for tagging proteins with lanthanide ions. Journal of Biomolecular NMR, 50 4: 411-420. doi:10.1007/s10858-011-9529-x Jia, Xinying, Maleckis, Ansis, Huber, Thomas and Otting, Gottfried (2011) 4,4′-dithiobisdipicolinic acid: a small and convenient lanthanide binding tag for protein NMR spectroscopy. Chemistry - A European Journal, 17 24: 6830-6836. doi:10.1002/chem.201003573 Jia, Xinying, Ozawa, Kiyoshi, Loscha, Karin and Otting, Gottfried (2009) Glutarate and N-acetyl-L-glutamate buffers for cell-free synthesis of selectively 15N-labelled proteins. Journal of Biomolecular NMR, 44 2: 59-67. doi:10.1007/s10858-009-9315-1 He, Qing-Li, Jia, Xin-Ying, Tang, Man-Cheng, Tian, Zhen-Hua, Tang, Gong-Li and Liu, Wen (2009) Dissection of two acyl-transfer reactions centered on acyl-s-carrier protein intermediates for incorporating 5-chloro-6-methyl-O-methylsalicyclic acid into chlorothricin. ChemBioChem, 10 5: 813-819. doi:10.1002/cbic.200800714 Wu, Zuopeng, Jia, Xinying, de la Cruz, Laura, Su, Xun-Cheng, Marzolf, Bruz, Troisch, Pamela, Zak, Daniel, Hamilton, Adam, Whittle, Belinda, Yu, Di, Sheahan, Daniel, Bertram, Edward, Aderem, Alan, Otting, Gottfried, Goodnow, Christopher C. and Hoyne, Gerard F. (2008) Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL. Immunity, 29 6: 863-875. doi:10.1016/j.immuni.2008.11.004